Admedus

[Ehhhhhhh]

Hoping for good news! Would someone be able to attend this webinar and update us? You can register to attend on their Facebook. 

[oneday]

Who else has registered for webinar? 

[crisper]

19 hours ago, oneday said:

Who else has registered for webinar? 

I registered. 

[moialbalushi]

I came to this site to post this. lol. I registered for it. hope that mr.josh bloom shades the light on this one just like he did for gennocea and theravax. I beleive in these two vaccines but the adnedus one is the most trusted one in my openion. Anyone is able to record the webinar ? 

if there is a way to record it please try guys. any one has experience in this ? 

 

[oneday]

Also posted on other Admedus thread:

 

So I listened to webinar this morning. It was recorded by Admedus so people should be able to access it later. From what I took away, reduction from vaccine post booster was approx. 50-65%. There was one moderate adverse reaction experienced by a participant in the trial most likely resulting from vaccine. Time to recurrence was approx. 6 months for vaccine arm vs about 1 month for placebo arm. The company are looking to run a phase IIb trial to increase dose of vaccine and possibly change approaches used to administer vaccine. Admedus is excited by the results. 

[Justin Owens]

So if they go up on the dose of the vaccine then percentage rate will likely go up higher?

[Whyyyyy]

22 minutes ago, oneday said:

Also posted on other Admedus thread:

 

So I listened to webinar this morning. It was recorded by Admedus so people should be able to access it later. From what I took away, reduction from vaccine post booster was approx. 50-65%. There was one moderate adverse reaction experienced by a participant in the trial most likely resulting from vaccine. Time to recurrence was approx. 6 months for vaccine arm vs about 1 month for placebo arm. The company are looking to run a phase IIb trial to increase dose of vaccine and possibly change approaches used to administer vaccine. Admedus is excited by the results. 

Reduction of what exactly? Frequency of OB's?

[Whyyyyy]

19 minutes ago, Justin Owens said:

So if they go up on the dose of the vaccine then percentage rate will likely go up higher?

I would like to know this as well. & was shedding mentioned?

[northwest_lurker]

http://clients2.weblink.com.au/news/pdf_1\01854318.pdf

[Joseph_Esp]

Man, this vaccine was a total failure... Read the report, 0 improvements compared to placebo group.

[moialbalushi]

6 hours ago, Whyyyyy said:

I would like to know this as well. & was shedding mentioned?

I think  yes. I remember reading one of their reports. As I remember, they applied a higher dose and it had an impact on patients

[moialbalushi]

1 minute ago, Joseph_Esp said:

Man, this vaccine was a total failure... Read the report, 0 improvements compared to placebo group.

I still don't understand, how comes it a failiure ? they mentioned it is positive results !!

[moialbalushi]

i just checked the admedus results again. they stated : 

"Percentage of subjects with no outbreaks post vaccination in the vaccine group (29.4% n= 10) compared to the placebo group (10.0% n=1)."

so there is actually a difference. still we need to see what happens in phase2b. stay positive guys. We need to support this vaccine also because they have achieved something at least and its not unwanted at all. 1 outbreak in 6 months without the higher dose!! dont you think that this is a big achievement ? I hope josh bloom can check on the results and give his comments about them. can anyone tell me how to contact him plz ? 

 

Remember my friends, we all want a vaccine and this vaccine is so trusted in my opinion because it is made by a great doctor which is Ian Frazer. This doctor is the same one who created Gardasil for cervical cancer !! Im sure he knows what he is doing.

Edited May 4, 2017 by moialbalushi

[Sanguine108]

garbage results.  Only a matter of time before scientists (or more so the investors) realize that these subunit vaccines are a waste of time and money.

I understand the Frazer hype but the results are clearly GARBAGE.

[Joseph_Esp]

7 minutes ago, Sanguine108 said:

garbage results.  Only a matter of time before scientists (or more so the investors) realize that these subunit vaccines are a waste of time and money.

I understand the Frazer hype but the results are clearly GARBAGE.

I don't know if there are reasons to be optimistic at all anymore; Theravax and Gen-003 showed similar results, which might mean a), they worked "a bit" or b), reductions in shedding were not vaccine related. But yes, this vaccine was real garbage.

1 hour ago, moialbalushi said:

I still don't understand, how comes it a failiure ? they mentioned it is positive results !!

Read the report yourself.

[moialbalushi]

1 minute ago, Joseph_Esp said:

I don't know if there are reasons to be optimistic at all anymore; Theravax and Gen-003 showed similar results, which might mean a), they worked "a bit" or b), reductions in shedding were not vaccine related. But yes, this vaccine was real garbage.

Read the report yourself.

I read it and what I understood is that the outbreaks became once in 6 months !! that isn't good ?

[moialbalushi]

19 minutes ago, Joseph_Esp said:

I don't know if there are reasons to be optimistic at all anymore; Theravax and Gen-003 showed similar results, which might mean a), they worked "a bit" or b), reductions in shedding were not vaccine related. But yes, this vaccine was real garbage.

Read the report yourself.

Is it possible to explain what you understood from the report please ? 

Edited May 4, 2017 by moialbalushi

[Sanguine108]

10 minutes ago, Joseph_Esp said:

I don't know if there are reasons to be optimistic at all anymore; Theravax and Gen-003 showed similar results, which might mean a), they worked "a bit" or b), reductions in shedding were not vaccine related. But yes, this vaccine was real garbage.

Yeah, I think it'd be interesting if the prophylactic vaccines work in humans as well as they do in small animals.

Halford's vaccine is neat bc it's live and he's testing it on actual people.   I'm not 100% positive but I believe the gene he deleted involves viral replication.
The gD-2 deleted live vaccine will be interesting. Hopefully it'll get to humans trials sooner than later.  gD-2 is surface protein on HSV that's believed to be involved with infectiousness and immune system evasiveness.  Dr. William Jacobs of Yeshiva (Einstein univ) is working on the gD-2 deleted live vaccine. Very excited to see what he produces next.

But why I mention this... Frazer even says in one of his publications and I quote, "My vaccine is complete garbage compared to the deleted gD-2 live vaccine."  Kidding aside, Frazer did publish a paper where he compared his vaccine to the live, delta-gD-2 vaccine and the delta-gD-2 vaccine performed better than his.  ( For those who don't know, delta means changed. So what was changed in a specimen was that the gD-2 gene was removed)

[Joseph_Esp]

21 minutes ago, Sanguine108 said:

Yeah, I think it'd be interesting if the prophylactic vaccines work in humans as well as they do in small animals.

Halford's vaccine is neat bc it's live and he's testing it on actual people.   I'm not 100% positive but I believe the gene he deleted involves viral replication.
The gD-2 deleted live vaccine will be interesting. Hopefully it'll get to humans trials sooner than later.  gD-2 is surface protein on HSV that's believed to be involved with infectiousness and immune system evasiveness.  Dr. William Jacobs of Yeshiva (Einstein univ) is working on the gD-2 deleted live vaccine. Very excited to see what he produces next.

But why I mention this... Frazer even says in one of his publications and I quote, "My vaccine is complete garbage compared to the deleted gD-2 live vaccine."  Kidding aside, Frazer did publish a paper where he compared his vaccine to the live, delta-gD-2 vaccine and the delta-gD-2 vaccine performed better than his.  ( For those who don't know, delta means changed. So what was changed in a specimen was that the gD-2 gene was removed)

Yeah, but the Einstein vaccine is still in preclinical; at least 7 years till it makes it to the market, let's say... Hopefully gene-editing or Halford make it sooner.

Edited May 4, 2017 by Joseph_Esp

[JJ2017]

I think CRISPR is the strongest contender now, Halfords vax is unlikely to be significant improvement on Gen-003/Admedus

[Whyyyyy]

25 minutes ago, JJ2017 said:

I think CRISPR is the strongest contender now, Halfords vax is unlikely to be significant improvement on Gen-003/Admedus

Did you see the Gen-003 news released today? Supposedly if given  3 shots at two week intervals it's good for two years. I didn't understand the shedding data but it's better than nothing...

Edited May 4, 2017 by Whyyyyy

[JJ2017]

http://ir.genocea.com/releasedetail.cfm?ReleaseID=1024759  << these results, yeah i saw them......seem similar to admedus because im sure that data was based on 2 shots. may be worth its own thread to compare the 2 

[Whyyyyy]

3 minutes ago, JJ2017 said:

http://ir.genocea.com/releasedetail.cfm?ReleaseID=1024759  << these results, yeah i saw them......seem similar to admedus because im sure that data was based on 2 shots. may be worth its own thread to compare the 2 

A bit underwhelming, as it's not a cure but it's better than nothing!

[Penumbra]

I'm reading this thread and wonder what's the deal with some people on here.
Jesus christ get a hold of yourself.  

[moialbalushi]

1 minute ago, Penumbra said:

I'm reading this thread and wonder what's the deal with some people on here.
Jesus christ get a hold of yourself.  

Exactly. I came to this site to gain positivity. What i saw is the opposite. Hope people realize that its their voice and vote for gennocea is going to be heard. We need to show that we interested in that vaccine , also the admedus one. Something is better than nothing !!