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    • Just a human being
      People say they want a cure but some days I wonder. If you express how stressful it’s been to support a small cohort through treatment with limited evidence most do not understand, when you ask for support or your struggles to cope with people’s trauma in treatment, or the ingrained societal perceptions, when you try to talk about the evidence it’s like you’ve done some evil thing! Apparently going against the grain to do what’s right is not worthy of human understanding or support! Expressing human vulnerability also appears to be incredibly evil! Damn! Any weakness or difficulties damn your just not worthy of care, support or respect!  After over a year in the space it’s so clear to me why there has been no progress. You are completely ostracized from the community for speaking out on this topic. How many are voiceless here too scared to speak? Yet we rarely hear from you. When you are successful you just disappear (Of course because we don’t hear from you you don’t exist! You must be a “conspiracy theory”. And even if you did then you would just be anecdotal and oh yeah that publishing evidence when they attempt to discredit it... hmm be interesting to hear the “conspiracy” stories on that one...)and I understand why as no one would listen to you anyhow! I hope for anyone reading this you get out alive lest you become a lost soul in purgatory stamping out hope for others due to confusion weaved in science and medicine.   
    • MikeHerp
      Not directly on HSV, but this general overview of where gene editing is, is a very good read. Recommend at least skimming it. A lot of excitement is building around gene editing.  https://67c5cfaa-bdc0-42a5-95c4-a822adc972c7.filesusr.com/ugd/80a6fd_a53ed12021a54292bb50ed1255e31118.pdf
    • Just a human being
      It s not really possible to ban anyone from this forum. Some people would just get back on and create a reign of terror in their wrath. I’ve seen it before. In the end everyone has to accept them and it teaches the group tolerance. Trust me I’ve been through the same feelings and I don’t want to act like I’m always Mr positive or anything cos I am Just a human being!And honestly we need to consider others welfare. They would be lost without this forum. I think if you took it away they would suffer serious trauma. It just takes a small amount of time to work around it! I have deep respect for @MikeHerp it takes a lot of work to get something like this off the ground! I think genetic research is very valuable and important!  I have duel interests human systems and health and agriculture. In the agriculture realm I’m not a big fan of say Monsanto’s brand of genetic research in application. I am a big fan of genetic research to inform plant breeding!  I think this is good work that will be insightful for humans in the future! Don’t take a few difficult people to heart! Trust me I do know it’s difficult.  I didn’t even read a single comment of theirs! Wow that’s big for me! Back to Fred Hutch....    
    • MikeHerp
      What I find interesting about this trial is that even though half life is 25 days, measurements of shedding and lesions will be done until nearly 4 months.  Maybe they expect the effect to last longer than the half life (maybe the binding effect survives longer than the half life). 
    • MikeHerp
      Message from FHC philanthropy:   “There is a small glitch with the website that we are working on. The page is still live, located here: http://engage.fredhutch.org/site/TR/PersonalFundraisingPages/General?px=1802786&pg=personal&fr_id=1574 I will need to request a new link to "fredhutch.org/hsv" for you on Monday, which is not working right now, but you can access the site from the link above in the meantime. I will let you know when that is fixed”
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Sophie76

Accuracy of igg test at 9 weels?

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Sophie76

I'm hearing a lot of different things and it's frustrating me. It's saying that 25% of tests miss hsv 1 and then that 1 in 10 tests are missed anyway. On the other hand it says that around 80-90% accuracy of a igg test at 9 weeks? Very confused with all these statistics. Can I trust me negative at 9 weeks? 

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WilsoInAus

It is not quite known the exact accuracy of HSV-1 testing, but it would probably exceed 90% accurate for a recently infected person. Combined with negative swabs or nothing to swab gets you close to 100% sure.

HSV-2 testing is over 98% accurate.

That is ultimate accuracy usually achieved by 16 weeks.

You are also referring to seroconversion that occurs progressively from about 3 weeks after infection until 16 weeks.

At 9 weeks 90% of infections (that are going to be detected) will be detected.

I would repeat the test at 16 weeks to be sure and take the result as conclusive.

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Sophie76
15 minutes ago, WilsoInAus said:

It is not quite known the exact accuracy of HSV-1 testing, but it would probably exceed 90% accurate for a recently infected person. Combined with negative swabs or nothing to swab gets you close to 100% sure.

HSV-2 testing is over 98% accurate.

That is ultimate accuracy usually achieved by 16 weeks.

You are also referring to seroconversion that occurs progressively from about 3 weeks after infection until 16 weeks.

At 9 weeks 90% of infections (that are going to be detected) will be detected.

I would repeat the test at 16 weeks to be sure and take the result as conclusive.

Thank you so much for your reply, that has cleared a lot of the confusion! 

Please can you explain what you mean by the seroconversion section? 

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LillianPanos

Igg testing is awful at 1 year I show no hsv2. Show hsv 1 from childhood

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Sophie76
4 minutes ago, LillianPanos said:

Igg testing is awful at 1 year I show no hsv2. Show hsv 1 from childhood

I'm sorry to hear that :( must be very confusing and frustrating. It's frustrating how the accuracy of this test isn't as good as ones for other stis. You would have thought it would be more accurate by now. 

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Sophie76
26 minutes ago, WilsoInAus said:

It is not quite known the exact accuracy of HSV-1 testing, but it would probably exceed 90% accurate for a recently infected person. Combined with negative swabs or nothing to swab gets you close to 100% sure.

HSV-2 testing is over 98% accurate.

That is ultimate accuracy usually achieved by 16 weeks.

You are also referring to seroconversion that occurs progressively from about 3 weeks after infection until 16 weeks.

At 9 weeks 90% of infections (that are going to be detected) will be detected.

I would repeat the test at 16 weeks to be sure and take the result as conclusive.

Also you mention that 90% of infections that are going to be detected will be. So you mean the percentage of people on average will test accurately at 9 weeks? 

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LillianPanos
3 hours ago, Sophie76 said:

I'm sorry to hear that :( must be very confusing and frustrating. It's frustrating how the accuracy of this test isn't as good as ones for other stis. You would have thought it would be more accurate by now. 

And a cure by mNow

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