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    • Just a human being
      People say they want a cure but some days I wonder. If you express how stressful it’s been to support a small cohort through treatment with limited evidence most do not understand, when you ask for support or your struggles to cope with people’s trauma in treatment, or the ingrained societal perceptions, when you try to talk about the evidence it’s like you’ve done some evil thing! Apparently going against the grain to do what’s right is not worthy of human understanding or support! Expressing human vulnerability also appears to be incredibly evil! Damn! Any weakness or difficulties damn your just not worthy of care, support or respect!  After over a year in the space it’s so clear to me why there has been no progress. You are completely ostracized from the community for speaking out on this topic. How many are voiceless here too scared to speak? Yet we rarely hear from you. When you are successful you just disappear (Of course because we don’t hear from you you don’t exist! You must be a “conspiracy theory”. And even if you did then you would just be anecdotal and oh yeah that publishing evidence when they attempt to discredit it... hmm be interesting to hear the “conspiracy” stories on that one...)and I understand why as no one would listen to you anyhow! I hope for anyone reading this you get out alive lest you become a lost soul in purgatory stamping out hope for others due to confusion weaved in science and medicine.   
    • MikeHerp
      Not directly on HSV, but this general overview of where gene editing is, is a very good read. Recommend at least skimming it. A lot of excitement is building around gene editing.  https://67c5cfaa-bdc0-42a5-95c4-a822adc972c7.filesusr.com/ugd/80a6fd_a53ed12021a54292bb50ed1255e31118.pdf
    • Just a human being
      It s not really possible to ban anyone from this forum. Some people would just get back on and create a reign of terror in their wrath. I’ve seen it before. In the end everyone has to accept them and it teaches the group tolerance. Trust me I’ve been through the same feelings and I don’t want to act like I’m always Mr positive or anything cos I am Just a human being!And honestly we need to consider others welfare. They would be lost without this forum. I think if you took it away they would suffer serious trauma. It just takes a small amount of time to work around it! I have deep respect for @MikeHerp it takes a lot of work to get something like this off the ground! I think genetic research is very valuable and important!  I have duel interests human systems and health and agriculture. In the agriculture realm I’m not a big fan of say Monsanto’s brand of genetic research in application. I am a big fan of genetic research to inform plant breeding!  I think this is good work that will be insightful for humans in the future! Don’t take a few difficult people to heart! Trust me I do know it’s difficult.  I didn’t even read a single comment of theirs! Wow that’s big for me! Back to Fred Hutch....    
    • MikeHerp
      What I find interesting about this trial is that even though half life is 25 days, measurements of shedding and lesions will be done until nearly 4 months.  Maybe they expect the effect to last longer than the half life (maybe the binding effect survives longer than the half life). 
    • MikeHerp
      Message from FHC philanthropy:   “There is a small glitch with the website that we are working on. The page is still live, located here: http://engage.fredhutch.org/site/TR/PersonalFundraisingPages/General?px=1802786&pg=personal&fr_id=1574 I will need to request a new link to "fredhutch.org/hsv" for you on Monday, which is not working right now, but you can access the site from the link above in the meantime. I will let you know when that is fixed”
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cantdoit

Transmission

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cantdoit

A question about spreading hsv2

 

1.  If you are asymptomatic do you shed; and

 

2.  If taking antivirals, and using condoms what is the chance of spreading it to a man. 

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WilsoInAus

Everyone sheds, but it is not known exactly how much for an individual, nor does it matter in a way, as shedding does not equal transmission probability. Most shedding involves way too little of the virus to infect anything.

The population average using antivirals and condoms is about 2% a year as mentioned. This includes some 'average' usage of antivirals and condoms!

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Cas9
9 hours ago, cantdoit said:

A question about spreading hsv2

 

1.  If you are asymptomatic do you shed; and

 

2.  If taking antivirals, and using condoms what is the chance of spreading it to a man. 

Yes, if you are asymptomatic, it means you only shed. Spreading the herpes infection mostly occurs through shedding, because people who are asymptomatic typically don't know that they have herpes and therefore take no precautions. That said, I haven't seen any stats that specify the chances of spreading the virus if you are shedding at a specific time and have skin to skin contact with someone at that time. I would think that that would be difficult to determine.

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Lisajd

My understanding is that if you don't have an outbreak you shed less and also during the first year you shared more and given that you have had it for longer than a year and don't have symptoms if you use condoms and take medication my understanding is that it is 1%.  If this new guy is ok with it just take the precautions as best as you can and he is taking that risk remember that

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JHenry

Do people who have zero to very few occurences a year, also have less asymptomatic shedding than those who who do?   Thanx.

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