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Looks like there is now a site that's in English selling Amenalief (amenamevir) for the rock bottom price of about $95.43 USD a day. ($668 shipped for 14 x 200mg pills at 400mg/ daily dose). Amenalief is one of the helicase primase-inhibitor class of drugs that has been around for the better part of a couple decades, but has just recently made it to market in Japan. Pritelivir is also a member of this drug class. For those that have less than stellar results from current antivirals, helicase primase-inhibitors are likely to offer a relatively impressive improvement in quality of life assuming you can afford the ongoign cost of using them suppressively (needless to say they are NOT a cure). As a side note, the FDA blocked further testing of Pritelivir back in 2013, so in case you're wondering why you cannot buy this class of drugs as a consumer at your local pharmacy for a more reasonable price using your prescription drug plan, you owe a large thanks to the FDA for your being forced to weight your physical and emotional HSV-related damages against the cost of this treatment.

If anyone out there is independently wealthy, willing to order an antiviral drug from a Japanese company, and would be so kind as to report back with their experiences taking Amenalief suppressively, I'm sure many of your fellow sufferers would be extremely thankful!

https://www.mimaki-family-japan.com/item/detail?item_prefix=TF&item_code=705711&item_branch=001

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So that's $720 for 14 pills, or $51 per pill. Need two pills per day, so $102.8. There's 365 days in a year. So roughly $37,522 per year. I'd actually consider paying that. Combine it with Famciclovir and if I don't get outbreaks and could do a shedding study I might get my life back?

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I read that for daily suppression therapy you only need 400mg per week not per day. I believe that is the dosage for reactive therapy during a breakout. That would only cost $100 per week which is worth it if it works

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True that was Pritelivir but they use similar doses in studies of ASP2151 (amenalief). https://academic.oup.com/jid/article/205/7/1100/788596g

Also based on the dosages prescribed for Valtrex it’s much higher when comparing shingles and episodic hsv2 with suppression therapy doses so I personally wouldn’t risk taking something long term in such high doses in case of it being toxic at that amount. 

But im keen to try it in a small daily does (100mg) along with Valtrex (500mg) per day and see how I feel.

I placed an order yesterday!

 

 

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Hi Lamaa, yes I’ve been taking 100mg of amenalief (half a tablet) daily for 3 months now. I definitely don’t feel the virus in my body like I used to. I was getting tingles and a pain down my leg etc.. and that has all gone. I am taking 500mg of valtrex daily as well but have been on that for 18 months. I felt like valtrex was just holding the herpes back but adding the anenalief has done much more. I’d love to test my shedding rates to know for sure but based on the lack of prodrome symptoms I believe that it’s reduced my shedding. I think it’s something you should try if your prepared to spend the money. I’ll report back in another few months to keep you updated. 

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On 6/25/2018 at 12:20 AM, Rubberman said:

Hi Lamaa, yes I’ve been taking 100mg of amenalief (half a tablet) daily for 3 months now. I definitely don’t feel the virus in my body like I used to. I was getting tingles and a pain down my leg etc.. and that has all gone. I am taking 500mg of valtrex daily as well but have been on that for 18 months. I felt like valtrex was just holding the herpes back but adding the anenalief has done much more. I’d love to test my shedding rates to know for sure but based on the lack of prodrome symptoms I believe that it’s reduced my shedding. I think it’s something you should try if your prepared to spend the money. I’ll report back in another few months to keep you updated. 

How do you test your shedding rates? 

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I have also ordered and received Amenalief from Japan. Have not had many outbreaks or prodrome symptoms on 500 mg of Famciclovir a day but it still happens occasionally. I'm hoping Amenalief can all but eliminate the symptoms. I'm going to add 100 mg of Amenalief and see what happens. Will report back!

 

@Rubberman Have you noticed any side effects or done bloodwork?

Edited by destroyhsv
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I really need information about Amenalief. I want to purchase but can't, due price tag. Do anyone know price will decrease after a year of launch. Any one from Japan here. 

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On 7/5/2018 at 5:17 PM, Southwestrancher said:

Does it eliminate any chance of infecting others?

There's no data on shedding with Amenamevir that I've found and I've looked through every paper on Pubmed on Amenamevir. However, if you look at the in vitro data on Amenamevir, it is about as strong as Pritelivir against HSV-2 (I can provide a link to that if you want).  So, theoretically, a 100 mg dose will have a strong effect on shedding.

Also, since we want to combine Amenamevir and Valtrex/Famvir together, you should get a reduction from both Amenamevir and Valtrex/Famvir. There's research that shows they may have a synergistic antiviral effect.

Basically, in this study, they gave mice Valtrex, Amenamevir, and both Valtrex and Amenamevir and the total antiviral effect of the combo was strong than the effect of each drug added together. 

So although there is no hard data, I believe based on the in vitro data and in vivo studies that this combo will SIGNIFICANTLY decrease shedding and the risk of transmission. My optimistic guess is that it would be better than Pritelivir alone, and Pritelivir alone puts shedding at ~2% of days when used at 75-100 mg.

(there is publicly available shedding data for Pritelivir but not Amenamevir). 

Edited by destroyhsv
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Southwestrancher

It has to be zero % transmission rate for me to be interested. Less than 2% rates doesn't do it. You'd still have to have "the conversation".

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On 7/6/2018 at 7:57 PM, Southwestrancher said:

It has to be zero % transmission rate for me to be interested. Less than 2% rates doesn't do it. You'd still have to have "the conversation".

2 % transmission rate wouldn't guarantee no transmission but it would make it nearly impossible to transmit, for what it's worth. Plus the amount of virus being shed during an episode is significantly less which further decreases the chance of infection. But you are right that there is no guarantee.

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On 6/25/2018 at 12:20 AM, Rubberman said:

Hi Lamaa, yes I’ve been taking 100mg of amenalief (half a tablet) daily for 3 months now. I definitely don’t feel the virus in my body like I used to. I was getting tingles and a pain down my leg etc.. and that has all gone. I am taking 500mg of valtrex daily as well but have been on that for 18 months. I felt like valtrex was just holding the herpes back but adding the anenalief has done much more. I’d love to test my shedding rates to know for sure but based on the lack of prodrome symptoms I believe that it’s reduced my shedding. I think it’s something you should try if your prepared to spend the money. I’ll report back in another few months to keep you updated. 

Are you still taking amenalief? How is it going?

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For those on a budget there is Shanghai Soyoung on Alibaba.  They have a pretty good reputation, but you would still want to have the product tested at a lab.  I would love to trust it because I can see myself eating a spoonful for breakfast each morning. 

acv.JPG

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