If you’ve followed this ASP2151 thread, you may know that I’ve been taking amenamevir (Amenalief) for about two months. In these two months, I have had absolutely no symptoms and no side effects to speak of. I’m ordering blood work soon to confirm that there are no major changes in important biomarkers (kidney, liver, heart, etc.) but I haven’t experienced any side effects that I could observe myself (headaches, diarrhea, insomnia, mood changes etc.) However, there is no data about the effectiveness of valacyclovir + amenamevir on reducing HSV recurrences. Two months of being on this combination is not enough to tell how well it works.
As a community, what we need is a functional cure. There’s a lot of excitement surrounding pritelivir in this regard. Pritelivir, like amenamevir, is a new drug inhibits the HSV helicase-primase complex. This is a different target than valacyclovir, which is why combining the two has major potential to be a functional cure. If you’ve read Josh Bloom’s article on the possibility of using pritelivir and valacyclovir together as a sort of HIV-like cocktail, then you’ve probably realized this combo is the only way in the foreseeable future that we will have a functional cure.
Here’s the reality of the situation.
There will not be a vaccine in the foreseeable future (barring a miracle that allows GEN-003 to continue. I wouldn’t count on that).
There will not be a CRISPR treatment in the foreseeable future.
The only HSV drug that is going through clinical trials (past pre-clinical) is pritelivir. That means that aside from amenamevir and pritelivir, there will not be any new drugs on the market for at least ten years.
You are not getting much help from the pharmaceutical companies. It’s the truth. Many people here are already aware of this. Look at the HSV pipeline. Other than the helicase-primase inhibitors, there is little to no progress being made, and the failure rate is incredibly high.
If you want, you can wait ten years hoping that the pharmaceutical companies come out with something. The only alternative is to conduct our own trials and gather some data.
There are plenty of drugs/supplements with studies that have some evidence to support their use in preventing HSV recurrences, but there’s not much consensus on whether they actually improve anything. A lot of them have been tested in animals, but not in humans for the purpose of reducing HSV recurrences. Others have been tested in early-stage trials with very small sample sizes and don’t achieve statistical significance, even if the results are promising:
Aspirin & other COX-2 inhibitors Another link
and plenty more.
Some people have also speculated that diet changes (ketogenic diet, intermittent fasting, etc.) also lead to dramatic improvement in symptoms. There is plenty of reason to be skeptical about these claims, especially when they only come from a small number of people. The sample size simply isn’t large enough.
And, of course, there’s a new drug that we know to be a strong inhibitor of HSV replication: amenamevir. Just as famciclovir has the same effect on HSV as valacyclovir, amenamevir has the same effect on HSV as pritelivir. And, as some of you know, amenamevir is approved in Japan and can be purchased online.
In many cases, valacyclovir by itself is not enough to stop all symptoms/recurrences. Additionally, valacyclovir doesn’t reduce shedding as much as it should. But research has found a strong correlation between number of recurrences and shedding. If we get recurrences down to zero, chances are that shedding is close to zero. At the very least, it means with very high probability that shedding has been significantly reduced.
Clearly, to achieve a functional cure, valacyclovir is not enough. But when combined it with other drugs/supplements/diets, it could achieve a functional cure or at least eliminate all outbreaks (which all but guarantees a very low level of shedding). Hypothetically, valacyclovir might reduce the average number of outbreaks per year from 3 to 1. Taking amenamevir in combination with valacyclovir might reduce that number to .5. Taking glutamine with amenamevir and valacyclovir might reduce that number to .2 (this is just a hypothetical example). Many of these combos may have a synergistic effect, meaning that using both drugs together would have a stronger effect than the effects of each individual drug combined. And how will we actually figure this out? By doing our own clinical trial.
We need a significant amount of participants. A trial will have at least sixty participants (more is better, but sixty is doable) for a three month period. I’ve created to gather some basic information about people (nothing personal or potentially identifying. Just things like age, time of diagnosis, frequency of outbreaks in the past year, whether or not they currently take medication. This data will help group the study participants properly) and a spreadsheet for a trial participant to record when they get an outbreak and to briefly describe the symptoms. The group will be split in half, with thirty participants taking only valacyclovir and the other half taking valacyclovir along with whatever we want to study in combination with valacyclovir. Other standard study procedures such as randomization of the groups will be incorporated into the trial. All the participants have to do is take the pills and record any outbreaks they have, briefly describe the symptoms, and write down when they are fully healed from the outbreak.
At the end of the trial, we will have three months of data for sixty participants. That’s ninety months, or seven and a half years of data, in each group. If the valacyclovir group had a total of ten outbreaks, then the average number of recurrences per year would be about 1.3. If the combo group had a total of five outbreaks, then the average number of recurrences would be about .7. Finally, we test to see if the combo led to a statistically significant reduction in outbreaks compared to the valacyclovir only group. The larger the study group, the more statistically significant the findings will be, which is why a large number of participants is crucial.
Finally, we finalize the trial by performing any other important data analysis. For example, we could see if there is any correlation between age and efficacy of the treatment. We generate graphs and charts and write a brief “paper” presenting the findings.
The only one of these trials that would actually “cost” a lot of money would be an amenamevir trial (amenamevir, although available, is pretty expensive). However, if enough people are willing to participate in one, we could get data on what looks to be the most effective treatment that is currently available.
A trial to assess the effect of any other drug, supplement, or diet would practically cost nothing. Aspirin, glutamine, lactoferrin, and propranolol are widely available and inexpensive, as are many of the other possible treatments, and these trials assume that participants are already taking valacyclovir whether it is covered by their insurance or not. And these trials do not require a major time commitment. The participant will have to verify at the beginning of the trial that they have the study drugs/supplements in their possession (just send a picture and blur out any personal info if there’s a prescription bottle). They take one or two pills a day and record any recurrences. In trials with potential side effects (e.g. lithium), the participant records any side effects. At the end of the study, the participant sends the spreadsheet over. That’s it.
These studies and data may not be as high quality as that of many clinical trials, but they are certainly useful. By obtaining this data, we give ourselves the ability to treat this disease better than ever before. Instead of shooting fish in a barrel and hoping some supplement works because one person on the internet said it did or because a supplement had an effect in an animal study, you’ll be able to rely on real data from humans. Not only that, but that data will be on a combination of valacyclovir and whatever else is being taken, which there are very few if any human studies on.
TL;DR: Doing crowdsourced trials on different combinations of valacyclovir and other compounds, we can see which compounds are effective for improving HSV. You can participate, and it is minimally time-consuming and costs next to nothing (unless you want to do an amenamevir trial). Participating will help us gather data to improve our conditions dramatically.
If you’re interested in participating, please fill out this form: https://goo.gl/forms/Q50PKY8I11tVMsLh2
I am not interested in anyone’s personal data. These studies are to remain anonymous and I will never ask for or attempt to collect any personal data. The only reason I ask for age in the form is because is a potential variable to account for in data analysis. You do not need to provide your age if you don't want to.
All communications should be done through this website’s messaging system or using an email that does not link to your identity. You can reach me at honeycombstudy at gmail.com or message me on this site.
Any questions and/or skepticism are more than welcome.
Finally, if anyone would like to contribute to this project please contact me! Let’s start taking action.
Have any one is diagnosed by sharing foods or drinks?It is possible or just a myth.On google mixed information is available.Anyone have inputs regarding this topic.
“I was tested, I’m clean,” he said on the phone
I said “Are you sure?” I didn’t like his tone
Can I see your results, in plain black and white?
Cause something feels off, I know it’s not right
“My blood tests all negative, I’m in the clear”,
I said “Where is HSV bloods, cause I don’t see it here?”
We both seemed confused, and picked up the phone
It’s not included in the panel? How should we have known?
Did I give it to him? Did he give it to me?
The CDC doesn’t test for herpes? HOW COULD THIS BE?
Did he cheat? Was it dormant? Did I pass on a disease?
No answers from lab coats to put me at ease
No bedside manner, or kindness in their voice
They decide what to test, what about our choice?
I have to beg and to plead to pay for a test?
Because knowing my own status will cause me more stress?
Is this all a joke? Some kind of enigma?
For a medical community to promote this kind of stigma?
“We don’t think the test will change a damn thing”
How about the psycological pain it will inevitably bring?
“We therefore encourage doctors not to run the test”
So let the poor symptomatics deal with the mess?
“Ignorance is bliss, so it’s better to not know”
And for everyone else, you reap what you sow?
“It’s a harmless skin condition,” they’ll tell you I’m sure
But let’s not test or talk about it, and not look for the cure
False positives, the stigma, and lies all around
A few examples as to why the CDC let’s us all down
DEATH TO THE CDC fuck it right up the ass
Include Hsv in the tests, we all may not pass
And that’s perfectly fine let’s talk about it more
Let’s normalize the STI, and the common cold sore.
So what sites are you guys considering? I've been on PS for a few months with no luck. I've also been on OKCupid and Bumble but I find myself stalling to actually meet up for fear of " the talk". What are your experiences?
I was diagnosed GHSV2+ in 7/2017. I had the strangest calmness the entire diagnosis period, it was truly bizarre. I guess I just wasn't really worried; I have this innate, basically primal, belief that there is a yin to every yang… an ‘intuition’’ if you will. For the sake of the length of this response, I won’t go too deep into what I believe. But to make a long story short, NO MATTER WHAT YOU BELIEVE we all come from the same place. Science says big bang, one event. Religion says we come from God, … one being. No matter your beliefs, all creation hypotheses are similar in that it was ONE thing/being/event that created everything. I abso-fuckin-lutely cannot and WILL NOT entertain the assumption that anything is "incurable." A hypothesis that is substantiated and proven over and over again becomes a theory. But a theory is not fact. The only things that have been proven is that WESTERN MEDICINE cannot cure Herpes, as of yet. Mind you, they have not and will never do any kind of legitimate research or trials on naturally occurring substances (esters, herbs, plants, trees, flowers, etc.). Why? Because it is illegal to paten nature. No paten = No money. They are making trillions of dollars a year on Herpes alone.
Before 1928, people died all the time of infections. The discovery of penicillin enabled mankind to say "hey, I have a cure for that!" But people all around the world have been curing infections for millennia with herbs. Example: I have an ear infection. My options are to 1. provide my body with proper nutrients, maybe stuff some garlic in my ear, and allow my body to do what its designed to do OR 2. (the lazy way) drop a few drippy drops of an antibiotic solution in my ear twice a day for 10 days. BOTH will work, but BIG PHARMA can only paten one, profit off one, and claim "curability" for one. Which do you think it is?! In my opinion, we will NEVER see a cure for herpes. Medically and symptomatically, Herpes just isn’t a big enough deal. No one has ever died from Herpes.
It is the 21st century and there are people out there, like me and possibly you, who don’t give a fork about big pharma’s claim to the incurability of Herpes. It is 08/2018 and I’ve had herpes for 13 months now. I have done an INSANE amount of research in the quest to cure myself. I have read (not many) testimonials from people claiming to have cured themselves. The problem (and scary part) is that these people won’t provide contact information, their names, or anything else identifying. The number of holistic healers who are dying and disappearing is honestly super forking scary. I want to know all your thoughts on this!! Comment down below.
Links to a few studies performed on esters and herbs proving viricidal efficacy: