Jump to content
World's Largest Herpes Support Group
TravisSmith

Pritelivir

Recommended Posts

TravisSmith

After weeks of research, I have found a company overseas that has Pritelivir... If you've never heard of it, feel free to Google it... It basically has twice the efficacy of Valtrex and will be available in many more countries eventually, but it's not cheap. I have a secondary lab lined up that will test it's validity as well. The cost is about $600/month if I purchase it just by myself (paid up front). I am willing to pay this. If someone else wants to join in for a bulk order with me, it will reduce the price to $330/month each. If there were 3 of us, it'd be closer to $200/month. If you are interested, let me know and we can discuss. 

Share this post


Link to post
Share on other sites
TravisSmith

It keeps getting reduced the more we order. But, it has to all be purchased up-front (4 years of pills minimum). So, if we get 3 of us, that's $200/month each x 12months x 4 years = about $10k each. 

Share this post


Link to post
Share on other sites
TravisSmith

Taken daily like Valtrex, but it's twice as effective at reducing symptoms and twice as effective at reducing chances of spreading it.. http://www.aicuris.com/111n94AiCuris-Announces-Publication-of-Phase-2-Clinical-Trial-Results-of-Investigational-Anti-Herpes-Simplex-Virus-Agent-Pritelivir-in-JAMA.htm I read somewhere as well that it's okay to take both daily for maximum suppression. 

Share this post


Link to post
Share on other sites
destroyhsv
1 hour ago, TravisSmith said:

Taken daily like Valtrex, but it's twice as effective at reducing symptoms and twice as effective at reducing chances of spreading it.. http://www.aicuris.com/111n94AiCuris-Announces-Publication-of-Phase-2-Clinical-Trial-Results-of-Investigational-Anti-Herpes-Simplex-Virus-Agent-Pritelivir-in-JAMA.htm I read somewhere as well that it's okay to take both daily for maximum suppression. 

Can you provide a link to where it says you can take both?

Share this post


Link to post
Share on other sites
Mackie82
2 hours ago, destroyhsv said:

Can you provide a link to where it says you can take both?

In which country it’s available ? 

Share this post


Link to post
Share on other sites
BeautyLover321

Is this drug safe?? I mean I'm assuming it is cus its been through trials but has anyone reported side effects?

Share this post


Link to post
Share on other sites
TravisSmith

Hey Mackie, send me a private message if you can. In the first there were mild, possibly no side effects. That's available online as well. 

Share this post


Link to post
Share on other sites
cracked

@TravisSmith by reducing symptoms what exactly do you mean? Just lesions and pain or something else?

Share this post


Link to post
Share on other sites
MikeHerp

This doesn't sound right.  Pritelivir is being developed by AiCuris and it's in clinical trials now.  I doubt it would be sold by another company when it hasn't been even approved for the company which is developing it.  

Share this post


Link to post
Share on other sites
Dying2Live
On 3/9/2018 at 10:19 AM, MikeHerp said:

This doesn't sound right.  Pritelivir is being developed by AiCuris and it's in clinical trials now.  I doubt it would be sold by another company when it hasn't been even approved for the company which is developing it.  

He's probably talking about the actual drug compound, which is known as BAY 57-1293. It's the same chemical, but it's not being sold as "Pritelivir." The testing and analysis for purity from the overseas factory would be critical. I am definitely interested because I suffer daily symptoms even on Valtrex or Famvir. Pritelivir works in a completely different way from the current drugs, and I would expect the effect on reduction of viral replication (and therefore symptoms and shedding) to be multiplicative if both types of drugs were used suppressively.

Edited by Dying2Live
typos

Share this post


Link to post
Share on other sites
lamaa

Any update on this? 

Has anyone looked into ASP2151 out of Japan?

 

Share this post


Link to post
Share on other sites
IamPositive
On 6/2/2018 at 9:05 AM, lamaa said:

Any update on this? 

Has anyone looked into ASP2151 out of Japan?

 

What’s that?

Share this post


Link to post
Share on other sites
ManagingIllness

This drug is still not even at phase III. I don't know how people are getting access to it... Be careful all.

Share this post


Link to post
Share on other sites
Dilan Melia
On Sat Jun 23 2018 at 5:44 AM, IamPositive said:

What’s that?

Amenalief 

Share this post


Link to post
Share on other sites
Ryan M.

What the hell? You guys. this is absolutely not safe. This has not gone through phase 3 testing. You'd risk your health to get a drug that's likely going to be available in two years IF it isn't toxic? Horrible choice making going on here. 

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

  • Similar Content

    • destroyhsv
      By destroyhsv
      If you’ve followed this ASP2151 thread, you may know that I’ve been taking amenamevir (Amenalief) for about two months. In these two months, I have had absolutely no symptoms and no side effects to speak of. I’m ordering blood work soon to confirm that there are no major changes in important biomarkers (kidney, liver, heart, etc.) but I haven’t experienced any side effects that I could observe myself (headaches, diarrhea, insomnia, mood changes etc.) However, there is no data about the effectiveness of valacyclovir + amenamevir on reducing HSV recurrences. Two months of being on this combination is not enough to tell how well it works.
      As a community, what we need is a functional cure. There’s a lot of excitement surrounding pritelivir in this regard. Pritelivir, like amenamevir, is a new drug inhibits the HSV helicase-primase complex. This is a different target than valacyclovir, which is why combining the two has major potential to be a functional cure. If you’ve read Josh Bloom’s article on the possibility of using pritelivir and valacyclovir together as a sort of HIV-like cocktail, then you’ve probably realized this combo is the only way in the foreseeable future that we will have a functional cure.
      Here’s the reality of the situation.
      There will not be a vaccine in the foreseeable future (barring a miracle that allows GEN-003 to continue. I wouldn’t count on that).
      There will not be a CRISPR treatment in the foreseeable future.
      The only HSV drug that is going through clinical trials (past pre-clinical) is pritelivir. That means that aside from amenamevir and pritelivir, there will not be any new drugs on the market for at least ten years.
      You are not getting much help from the pharmaceutical companies. It’s the truth. Many people here are already aware of this. Look at the HSV pipeline. Other than the helicase-primase inhibitors, there is little to no progress being made, and the failure rate is incredibly high.
      If you want, you can wait ten years hoping that the pharmaceutical companies come out with something. The only alternative is to conduct our own trials and gather some data.
      There are plenty of drugs/supplements with studies that have some evidence to support their use in preventing HSV recurrences, but there’s not much consensus on whether they actually improve anything. A lot of them have been tested in animals, but not in humans for the purpose of reducing HSV recurrences. Others have been tested in early-stage trials with very small sample sizes and don’t achieve statistical significance, even if the results are promising:
      L-Glutamine
      Propranolol
      Aspirin & other COX-2 inhibitors Another link
      Lithium
      Lactoferrin
      and plenty more.
      Some people have also speculated that diet changes (ketogenic diet, intermittent fasting, etc.) also lead to dramatic improvement in symptoms. There is plenty of reason to be skeptical about these claims, especially when they only come from a small number of people. The sample size simply isn’t large enough.
      And, of course, there’s a new drug that we know to be a strong inhibitor of HSV replication: amenamevir. Just as famciclovir has the same effect on HSV as valacyclovir, amenamevir has the same effect on HSV as pritelivir. And, as some of you know, amenamevir is approved in Japan and can be purchased online.
      In many cases, valacyclovir by itself is not enough to stop all symptoms/recurrences. Additionally, valacyclovir doesn’t reduce shedding as much as it should. But research has found a strong correlation between number of recurrences and shedding. If we get recurrences down to zero, chances are that shedding is close to zero. At the very least, it means with very high probability that shedding has been significantly reduced.
      Clearly, to achieve a functional cure, valacyclovir is not enough. But when combined it with other drugs/supplements/diets, it could achieve a functional cure or at least eliminate all outbreaks (which all but guarantees a very low level of shedding). Hypothetically, valacyclovir might reduce the average number of outbreaks per year from 3 to 1. Taking amenamevir in combination with valacyclovir might reduce that number to .5. Taking glutamine with amenamevir and valacyclovir might reduce that number to .2 (this is just a hypothetical example). Many of these combos may have a synergistic effect, meaning that using both drugs together would have a stronger effect than the effects of each individual drug combined. And how will we actually figure this out? By doing our own clinical trial.
      We need a significant amount of participants. A trial will have at least sixty participants (more is better, but sixty is doable) for a three month period. I’ve created to gather some basic information about people (nothing personal or potentially identifying. Just things like age, time of diagnosis, frequency of outbreaks in the past year, whether or not they currently take medication. This data will help group the study participants properly) and a spreadsheet for a trial participant to record when they get an outbreak and to briefly describe the symptoms. The group will be split in half, with thirty participants taking only valacyclovir and the other half taking valacyclovir along with whatever we want to study in combination with valacyclovir. Other standard study procedures such as randomization of the groups will be incorporated into the trial. All the participants have to do is take the pills and record any outbreaks they have, briefly describe the symptoms, and write down when they are fully healed from the outbreak.
      At the end of the trial, we will have three months of data for sixty participants. That’s ninety months, or seven and a half years of data, in each group. If the valacyclovir group had a total of ten outbreaks, then the average number of recurrences per year would be about 1.3. If the combo group had a total of five outbreaks, then the average number of recurrences would be about .7. Finally, we test to see if the combo led to a statistically significant reduction in outbreaks compared to the valacyclovir only group. The larger the study group, the more statistically significant the findings will be, which is why a large number of participants is crucial.
      Finally, we finalize the trial by performing any other important data analysis. For example, we could see if there is any correlation between age and efficacy of the treatment. We generate graphs and charts and write a brief “paper” presenting the findings.
      The only one of these trials that would actually “cost” a lot of money would be an amenamevir trial (amenamevir, although available, is pretty expensive). However, if enough people are willing to participate in one, we could get data on what looks to be the most effective treatment that is currently available.
      A trial to assess the effect of any other drug, supplement, or diet would practically cost nothing. Aspirin, glutamine, lactoferrin, and propranolol are widely available and inexpensive, as are many of the other possible treatments, and these trials assume that participants are already taking valacyclovir whether it is covered by their insurance or not. And these trials do not require a major time commitment. The participant will have to verify at the beginning of the trial that they have the study drugs/supplements in their possession (just send a picture and blur out any personal info if there’s a prescription bottle). They take one or two pills a day and record any recurrences. In trials with potential side effects (e.g. lithium), the participant records any side effects. At the end of the study, the participant sends the spreadsheet over. That’s it.
      These studies and data may not be as high quality as that of many clinical trials, but they are certainly useful. By obtaining this data, we give ourselves the ability to treat this disease better than ever before. Instead of shooting fish in a barrel and hoping some supplement works because one person on the internet said it did or because a supplement had an effect in an animal study, you’ll be able to rely on real data from humans. Not only that, but that data will be on a combination of valacyclovir and whatever else is being taken, which there are very few if any human studies on.
      TL;DR: Doing crowdsourced trials on different combinations of valacyclovir and other compounds, we can see which compounds are effective for improving HSV. You can participate, and it is minimally time-consuming and costs next to nothing (unless you want to do an amenamevir trial). Participating will help us gather data to improve our conditions dramatically.
      If you’re interested in participating, please fill out this form: https://goo.gl/forms/Q50PKY8I11tVMsLh2
      I am not interested in anyone’s personal data. These studies are to remain anonymous and I will never ask for or attempt to collect any personal data. The only reason I ask for age in the form is because is a potential variable to account for in data analysis. You do not need to provide your age if you don't want to.
      All communications should be done through this website’s messaging system or using an email that does not link to your identity. You can reach me at honeycombstudy at gmail.com or message me on this site.
      Any questions and/or skepticism are more than welcome.
      Finally, if anyone would like to contribute to this project please contact me! Let’s start taking action.

       
    • TravisSmith
      By TravisSmith
      I take Valtrex daily to prevent my wife from getting it. I also use a self-created acycliovir cream an hour before sex.... And, mix Truvada with lubricant to help as well (it has shown to help reduce chances of transmission). 
      Anyway, I was in touch with Rational vaccines (via phone) in Q4 of last year (they were in the Caribbean). Anyway, they have now gone MIA (feel free to Google it). So, I doubt that will be an option anymore.
      Gen 003 was cancelled.
      Pritelivir won't be available for a while here in the USA. However, I can get it from a company in Germany, and it will be expensive. If someone is intersted, message me, and we can get a bulk discount. Still it'll be about $9,000 each for a 4 year supply. I will put it on a credit card and make payments. 
      That's all my research so far. Hope this helps someone!
       
       
    • TravisSmith
      By TravisSmith
      After weeks of research, I have found a company overseas that has Pritelivir... If you've never heard of it, feel free to Google it... It basically has twice the efficacy of Valtrex and will be available in many more countries eventually, but it's not cheap. I have a secondary lab lined up that will test it's validity as well. The cost is about $600/month if I purchase it just by myself (paid up front). I am willing to pay this. If someone else wants to join in for a bulk order with me, it will reduce the price to $330/month each. If there were 3 of us, it'd be closer to $200/month. If you are interested, let me know and we can discuss. 
    • Dying2Live
      By Dying2Live
      Looks like there is now a site that's in English selling Amenalief (amenamevir) for the rock bottom price of about $95.43 USD a day. ($668 shipped for 14 x 200mg pills at 400mg/ daily dose). Amenalief is one of the helicase primase-inhibitor class of drugs that has been around for the better part of a couple decades, but has just recently made it to market in Japan. Pritelivir is also a member of this drug class. For those that have less than stellar results from current antivirals, helicase primase-inhibitors are likely to offer a relatively impressive improvement in quality of life assuming you can afford the ongoign cost of using them suppressively (needless to say they are NOT a cure). As a side note, the FDA blocked further testing of Pritelivir back in 2013, so in case you're wondering why you cannot buy this class of drugs as a consumer at your local pharmacy for a more reasonable price using your prescription drug plan, you owe a large thanks to the FDA for your being forced to weight your physical and emotional HSV-related damages against the cost of this treatment.
      If anyone out there is independently wealthy, willing to order an antiviral drug from a Japanese company, and would be so kind as to report back with their experiences taking Amenalief suppressively, I'm sure many of your fellow sufferers would be extremely thankful!
      https://www.mimaki-family-japan.com/item/detail?item_prefix=TF&item_code=705711&item_branch=001
    • Felina88
      By Felina88
      http://www.aicuris.com/111n94AiCuris-Announces-Publication-of-Phase-2-Clinical-Trial-Results-of-Investigational-Anti-Herpes-Simplex-Virus-Agent-Pritelivir-in-JAMA.htm
  • Trending Now

  • The Hive is Thriving!

    • Total Topics
      69,296
    • Total Posts
      466,215
  • Posts

    • Skrillah80
      So ur saying the herbalife was the key?? Olive leaf extract and pro biotic are good? How many mgs of Lysine did you take a day? 
    • that1youngguy
      hello all, update... so the white ulcer inside started around january 4... and today it is still there... no burning while i pee, just a constant mild irritation feel, no other symptoms i went back to get retested 2/12 so 2.5 months after exposure... including HSV, HIV, gon, chlam, everything came back negative... the doctor thinks it's some form of chlamydia, he gave my doxy for 10 days is it too soon to tell if i have HSV? is it possible to have an ulcer inside the urethra and be fungal or bacterial?
    • MikeHerp
      Probably not many.  I'm going to change my twitter symbol to the copper ribbon at least.  
    • nope1234
      okay! I guess I will just start at the basic dosage of vitamin C and go up every week little ? I take 1500 mg of super lysine like the bottle says and it still gives me gas and diarrhea. hoping it will pass if not I'll drop down to 2 a day! I really appreciate the advice! i know we would all.do ANYTNING to not have OB  at the moment idc about stigmas od boyfriends or dating or sex....I just care about FEELING healthy in my own skin. this is my one and only life 
    • Lulupazoola
      That sounds like a good place to begin.  The lysine worked really well for me for about a year and a half.  Then things got steadily worse for me and nothing worked until vitamin C.  My immune system is not that great even tho i take care of myself, so u may have good luck if u have a decent one.  With the vitamin c, u must 1) take it at intervals throughout the day, not all at once 2) dont increase the amount u r taking too fast 3) it will give u gas at higher doses and even diarrhea if u go crazy with it. These r signs to lower your dose!  If u can just control your OB's with vitamin c and lysine or anything else, maybe a cure will finally become available.  
×

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.