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brookeb300

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JHenry

Your going to have to help me.  Looks  interesting and important, but I need some educational help beyond that.  Thanks!

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ManagingIllness

Very good news!

HSV is latent in neurons, so getting a reliable editing technique for those cells, which in general reproduce slowly (e.g., over 1 year) is key. This is a great development, and will hopefully be applicable for getting AAV to infiltrate the neurons in our spines, such harbor the HSV.

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Louder

@JHenry
Recent study on CRISPR proved the efficiency of the method to target the Double ARN HSV virus to directly replace some segment in the goal of destroying it in the cells that HSV reproduce. They saw that they cannot destroy the virus cause there is a repair system in cells that repair the ARN after CRISPR tried to edit the genome. But, because there's always a but, the virus after CRIPR intervention stopped to reproduce and this is a great news! On the other hand there's still a problem, the cells that CRISPR target are reproductive cells(the most common in the body) and not the non-reproductive cells like the neurons where HSV is found latent. Those cells are reactivating occasionally and produce virus that will attack the other cells. Targeting the neuron is something difficult and that's why the virus is so hard to cure. With the new method suggested here, this method propose a way to introduce CRISPR protein in the neuron and so it can get the job done.

Another thing about CRISPR and why we don't use it actually in treatment currently is because playing at replacing genes can be dangerous, and further treatment using this technology must be able to accurately target just the virus itself and not the human DNA.

 

Hope it is more clear,

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hopeful22
6 hours ago, Louder said:

@JHenry
Recent study on CRISPR proved the efficiency of the method to target the Double ARN HSV virus to directly replace some segment in the goal of destroying it in the cells that HSV reproduce. They saw that they cannot destroy the virus cause there is a repair system in cells that repair the ARN after CRISPR tried to edit the genome. But, because there's always a but, the virus after CRIPR intervention stopped to reproduce and this is a great news! On the other hand there's still a problem, the cells that CRISPR target are reproductive cells(the most common in the body) and not the non-reproductive cells like the neurons where HSV is found latent. Those cells are reactivating occasionally and produce virus that will attack the other cells. Targeting the neuron is something difficult and that's why the virus is so hard to cure. With the new method suggested here, this method propose a way to introduce CRISPR protein in the neuron and so it can get the job done.

Another thing about CRISPR and why we don't use it actually in treatment currently is because playing at replacing genes can be dangerous, and further treatment using this technology must be able to accurately target just the virus itself and not the human DNA.

 

Hope it is more clear,

@Louder Hello Louder, do you have the article on this study that you're talking about? I would like to read it. Thanks 

Please see the link below on how Temple University is trying the same thing, working on the neurons. There is no new news since this article from Temple University, except of course Kamel Khalili, Ph.D who is the Principal Scientific Advisor at Excision Bio Therapeutics. They have not shared any news this year yet. again please see the link below. 

https://temple-news.com/researchers-aim-to-find-cure-for-herpes/

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