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doh!

Yip. Caught my eye too. And, if one has say hsv1, it provides about 40% "immunity" to hsv2 (not from this site)

This definitely caught my eye

"Development of an effective herpes simplex virus type 2 (HSV-2) prophylactic vaccine is a global priority to improve sexual health [1,2]. Although several HSV-2 subunit vaccine candidates appeared effective in animal models, these vaccines have failed to prevent HSV-2 disease in humans in Phase III clinical trials, despite eliciting high levels of neutralizing antibody "

 

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    • 1stAnd10
      By 1stAnd10
      FIRST TIME TO WEBSITE. HELP....  Had a single small spot show up on my penis.  Never had anything like it occur previously.  Showed up the morning after having oral and vaginal sex with my wife, each of the two previous days, like 6 hours after intercourse.  Went to my doctor the next day and he was unsure but suggested testing for HSV-1 and HSV-2 as precaution.  Lab Test Results:
      IGG HSV-1 = <0.90 Negative 
      IGG HSV-2 = 9.55 (>1.09)
      Needless to say I'm trying to wrap my brain around all of this....   Is it possible the above is a false positive?  Have been tested in past and been negative.   I don't know how I contracted it.  All very upsetting but my real concern is my wife. 
      I'm married in a monogamous relationship and have not been with anyone else for over 3 years.  My wife and I are very sexually active, having sex multiple times a week most weeks since August 2015.  I think the longest we have gone without sex is like 2 weeks and that's been very rare.  My wife has oral cold sore out breaks multiple times a year but to my knowledge hasn't had any genital herpe symptoms and has never been tested for HSV 1 or 2. 
      What is the likelihood my wife has HSV-2?  That she contacted HSV-2 from me, that I contracted it from her or that we both came into the relationship with it?  The reality is none of this really matters, I'm just so upset that it involves her.  My worst nightmare. 
      Since the spot popped up I have refrained from being sexual with my wife.  Felt like it would be a breach of trust to be sexual with her without telling her there could be an issue. I wanted the test results first and wanted to discuss with her so, if there was an issue, we could work through this together.  Its been two weeks and she has started making comments about not having sex and asking if something is wrong SO I have to address this now.  
      Shouldn't she go to the dr? Shouldn't we go together?  Shouldn't she get tested?
      My doctor, whom she goes to for general stuff as well, has acted like no big deal.  Told me I could have had this for years or gotten it six months ago, no one knows for sure and people have this and deal with this all the time.  Obviously, if she is negative iy can't be a resent infection. He has suggested  suppression therapy of 500mg Valacycovir daily for each of us.
      Any thoughts or comments? Thank you.
       
    • Jayday
      By Jayday
      What’s up all!! 
      I just wanna let you guys in on my first year of having hsv-2. I’ve had a very little first outbreak 2 small “sores” that were kinda apart, was scared went to urgent care and requested blood work and full STD PANEL, everything came back negative except for HSV-1 which I had as a young boy, and HSV-2 via IGG blood test. I must have had it for a while since it takes a while to build antibodies ( my levels were like 8 or9). Another reason I was scared was my gf was having UTI symptoms which she tested positive for it but I had her go get tested for HSV and she was positive via IGM...she was given antivirals but she only took them for a week. Now fast forward to here, we do not have any outbreaks or they might be so small we don’t even notice. We have a great sex life and are going strong. We do not blame each other because we both didn’t know who carried it first. But anyways just wanted to give update on my year and how it doesn’t bother my at having this disease, I forget about it most of the time. Thank for reading and god bless you all! 
    • Geometry
      By Geometry
      "For the first time, researchers have been able to use cryo-electron microscopy, to reveal the detailed structure of the common herpes virus."

      Sup y'all... this is the real-deal. The main problem with this disease has been that researchers literally haven't been able to see it... until now. So no wonder everything has failed miserably except our friend Valacyclovir Hydrochloride. It's amazing seeing this... isn't it kinda beautiful actually? This particular research was on HSV-1, but the work is ongoing and will be done on HSV-2 and all other herpes variants. If we can see it, we can kill it. I'll be paying attention to this research group like crazy now! 
      Here's one article: https://www.gla.ac.uk/news/headline_596519_en.html
      And here's the actual study- with pictures!
      https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2006191
      Here's the guy doing the study (my new hero lol):
      https://www.gla.ac.uk/researchinstitutes/iii/staff/davidbhella/#/researchinterests,grants,publications,articles
      And here's the research's group on their HSV-1 work:
      https://www.gla.ac.uk/researchinstitutes/iii/cvr/aboutus/viruseswestudy/hsv1/
      So yeah just my opinion but finally no more shooting in the dark- drug companies will be all over this and start creating new treatments based on the actual structure of this damn organism, so I'm very hopeful indeed. 
    • AllHailKarma
      By AllHailKarma
      Anyone else actually legit ok? After doing the research, finding out how to keep myself healthy, how to keep this in dormacy, plus seeing how large of a community is on this side of the fence.... like, I'm good. And everyone else really should take the time to read, watch videos, figure out how your own body works with this shit, keep this community close also. We're all gonna be fine.  I'm more annoyed by occasional indigestion honestly.
    • destroyhsv
      By destroyhsv
      If you’ve followed this ASP2151 thread, you may know that I’ve been taking amenamevir (Amenalief) for about two months. In these two months, I have had absolutely no symptoms and no side effects to speak of. I’m ordering blood work soon to confirm that there are no major changes in important biomarkers (kidney, liver, heart, etc.) but I haven’t experienced any side effects that I could observe myself (headaches, diarrhea, insomnia, mood changes etc.) However, there is no data about the effectiveness of valacyclovir + amenamevir on reducing HSV recurrences. Two months of being on this combination is not enough to tell how well it works.
      As a community, what we need is a functional cure. There’s a lot of excitement surrounding pritelivir in this regard. Pritelivir, like amenamevir, is a new drug inhibits the HSV helicase-primase complex. This is a different target than valacyclovir, which is why combining the two has major potential to be a functional cure. If you’ve read Josh Bloom’s article on the possibility of using pritelivir and valacyclovir together as a sort of HIV-like cocktail, then you’ve probably realized this combo is the only way in the foreseeable future that we will have a functional cure.
      Here’s the reality of the situation.
      There will not be a vaccine in the foreseeable future (barring a miracle that allows GEN-003 to continue. I wouldn’t count on that).
      There will not be a CRISPR treatment in the foreseeable future.
      The only HSV drug that is going through clinical trials (past pre-clinical) is pritelivir. That means that aside from amenamevir and pritelivir, there will not be any new drugs on the market for at least ten years.
      You are not getting much help from the pharmaceutical companies. It’s the truth. Many people here are already aware of this. Look at the HSV pipeline. Other than the helicase-primase inhibitors, there is little to no progress being made, and the failure rate is incredibly high.
      If you want, you can wait ten years hoping that the pharmaceutical companies come out with something. The only alternative is to conduct our own trials and gather some data.
      There are plenty of drugs/supplements with studies that have some evidence to support their use in preventing HSV recurrences, but there’s not much consensus on whether they actually improve anything. A lot of them have been tested in animals, but not in humans for the purpose of reducing HSV recurrences. Others have been tested in early-stage trials with very small sample sizes and don’t achieve statistical significance, even if the results are promising:
      L-Glutamine
      Propranolol
      Aspirin & other COX-2 inhibitors Another link
      Lithium
      Lactoferrin
      and plenty more.
      Some people have also speculated that diet changes (ketogenic diet, intermittent fasting, etc.) also lead to dramatic improvement in symptoms. There is plenty of reason to be skeptical about these claims, especially when they only come from a small number of people. The sample size simply isn’t large enough.
      And, of course, there’s a new drug that we know to be a strong inhibitor of HSV replication: amenamevir. Just as famciclovir has the same effect on HSV as valacyclovir, amenamevir has the same effect on HSV as pritelivir. And, as some of you know, amenamevir is approved in Japan and can be purchased online.
      In many cases, valacyclovir by itself is not enough to stop all symptoms/recurrences. Additionally, valacyclovir doesn’t reduce shedding as much as it should. But research has found a strong correlation between number of recurrences and shedding. If we get recurrences down to zero, chances are that shedding is close to zero. At the very least, it means with very high probability that shedding has been significantly reduced.
      Clearly, to achieve a functional cure, valacyclovir is not enough. But when combined it with other drugs/supplements/diets, it could achieve a functional cure or at least eliminate all outbreaks (which all but guarantees a very low level of shedding). Hypothetically, valacyclovir might reduce the average number of outbreaks per year from 3 to 1. Taking amenamevir in combination with valacyclovir might reduce that number to .5. Taking glutamine with amenamevir and valacyclovir might reduce that number to .2 (this is just a hypothetical example). Many of these combos may have a synergistic effect, meaning that using both drugs together would have a stronger effect than the effects of each individual drug combined. And how will we actually figure this out? By doing our own clinical trial.
      We need a significant amount of participants. A trial will have at least sixty participants (more is better, but sixty is doable) for a three month period. I’ve created to gather some basic information about people (nothing personal or potentially identifying. Just things like age, time of diagnosis, frequency of outbreaks in the past year, whether or not they currently take medication. This data will help group the study participants properly) and a spreadsheet for a trial participant to record when they get an outbreak and to briefly describe the symptoms. The group will be split in half, with thirty participants taking only valacyclovir and the other half taking valacyclovir along with whatever we want to study in combination with valacyclovir. Other standard study procedures such as randomization of the groups will be incorporated into the trial. All the participants have to do is take the pills and record any outbreaks they have, briefly describe the symptoms, and write down when they are fully healed from the outbreak.
      At the end of the trial, we will have three months of data for sixty participants. That’s ninety months, or seven and a half years of data, in each group. If the valacyclovir group had a total of ten outbreaks, then the average number of recurrences per year would be about 1.3. If the combo group had a total of five outbreaks, then the average number of recurrences would be about .7. Finally, we test to see if the combo led to a statistically significant reduction in outbreaks compared to the valacyclovir only group. The larger the study group, the more statistically significant the findings will be, which is why a large number of participants is crucial.
      Finally, we finalize the trial by performing any other important data analysis. For example, we could see if there is any correlation between age and efficacy of the treatment. We generate graphs and charts and write a brief “paper” presenting the findings.
      The only one of these trials that would actually “cost” a lot of money would be an amenamevir trial (amenamevir, although available, is pretty expensive). However, if enough people are willing to participate in one, we could get data on what looks to be the most effective treatment that is currently available.
      A trial to assess the effect of any other drug, supplement, or diet would practically cost nothing. Aspirin, glutamine, lactoferrin, and propranolol are widely available and inexpensive, as are many of the other possible treatments, and these trials assume that participants are already taking valacyclovir whether it is covered by their insurance or not. And these trials do not require a major time commitment. The participant will have to verify at the beginning of the trial that they have the study drugs/supplements in their possession (just send a picture and blur out any personal info if there’s a prescription bottle). They take one or two pills a day and record any recurrences. In trials with potential side effects (e.g. lithium), the participant records any side effects. At the end of the study, the participant sends the spreadsheet over. That’s it.
      These studies and data may not be as high quality as that of many clinical trials, but they are certainly useful. By obtaining this data, we give ourselves the ability to treat this disease better than ever before. Instead of shooting fish in a barrel and hoping some supplement works because one person on the internet said it did or because a supplement had an effect in an animal study, you’ll be able to rely on real data from humans. Not only that, but that data will be on a combination of valacyclovir and whatever else is being taken, which there are very few if any human studies on.
      TL;DR: Doing crowdsourced trials on different combinations of valacyclovir and other compounds, we can see which compounds are effective for improving HSV. You can participate, and it is minimally time-consuming and costs next to nothing (unless you want to do an amenamevir trial). Participating will help us gather data to improve our conditions dramatically.
      If you’re interested in participating, please fill out this form: https://goo.gl/forms/Q50PKY8I11tVMsLh2
      I am not interested in anyone’s personal data. These studies are to remain anonymous and I will never ask for or attempt to collect any personal data. The only reason I ask for age in the form is because is a potential variable to account for in data analysis. You do not need to provide your age if you don't want to.
      All communications should be done through this website’s messaging system or using an email that does not link to your identity. You can reach me at honeycombstudy at gmail.com or message me on this site.
      Any questions and/or skepticism are more than welcome.
      Finally, if anyone would like to contribute to this project please contact me! Let’s start taking action.

       
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    • joescrilla
      More confusion! So the results have come back for both of the partners that I've been with over the last 3-4 years and they are both negative for type 1 and type 2. Where do I go next? Any advice?
    • Gems
      please look through the forum in exact and careful detail and inform yourself of less than usual circumstances to cover yourself.

      auto inoculation is rare and it can happen. off objects is debated but some people claim it happens. some people have experienced it happens easily.

      so you know practice good hygiene. i personal think use a heated towel rail and make sure your towels are fully hot and dry. there were studies in the 80's showing it can live on towels for 75 hours. The herpes association say most experts agree it cannot be caught off a towel. That is most experts not all. Some people end up with it on their body and one has to wonder how? Towels I would guess.

      Things that tend to stay kinda wet or so on. cups are another one that fit that i think.

      I remember being at university once and being in the bathroom while a girl was on the phone to her friend.She thought she had a bite on her face but clear to me someone with herpes had kissed her on the cheek recently, it didnt look typical just her skin peeling. 

      I am not an expert though or a doctor so do your own research.  
       
    • Phoenixx
      Update: The creme that contains the tetrapodal zinc oxide still isn't available at Gorch Fock Apotheke Kiel. I called them today: same status as last year and they have no further information on when and if it will be available again.
    • Phoenixx
      Lilian, the zinc acetate we are talking about here is different from the tetrapodal zinc oxide that you are mentioning. But thanks for the reminder. The ointment that contains the tetrapodal zinc oxide still isn't available at Gorch Fock Apotheke Kiel. I called them today: same status as last year and they have no further information on when and if it will be available again.
    • Gems
      I've had neg swabs but I am sure you'll get it. Follow the process. I haven't read the thread in exact detail, but if you have documentation of doctors mishandling your case when you get/ if you get a poss inform them in writing as well as the medical board I think.  Under diagnosis is as problematic as false pos and reducing transmission is good.
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