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doh!

Yip. Caught my eye too. And, if one has say hsv1, it provides about 40% "immunity" to hsv2 (not from this site)

This definitely caught my eye

"Development of an effective herpes simplex virus type 2 (HSV-2) prophylactic vaccine is a global priority to improve sexual health [1,2]. Although several HSV-2 subunit vaccine candidates appeared effective in animal models, these vaccines have failed to prevent HSV-2 disease in humans in Phase III clinical trials, despite eliciting high levels of neutralizing antibody "

 

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    • Geometry
      By Geometry
      "For the first time, researchers have been able to use cryo-electron microscopy, to reveal the detailed structure of the common herpes virus."

      Sup y'all... this is the real-deal. The main problem with this disease has been that researchers literally haven't been able to see it... until now. So no wonder everything has failed miserably except our friend Valacyclovir Hydrochloride. It's amazing seeing this... isn't it kinda beautiful actually? This particular research was on HSV-1, but the work is ongoing and will be done on HSV-2 and all other herpes variants. If we can see it, we can kill it. I'll be paying attention to this research group like crazy now! 
      Here's one article: https://www.gla.ac.uk/news/headline_596519_en.html
      And here's the actual study- with pictures!
      https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2006191
      Here's the guy doing the study (my new hero lol):
      https://www.gla.ac.uk/researchinstitutes/iii/staff/davidbhella/#/researchinterests,grants,publications,articles
      And here's the research's group on their HSV-1 work:
      https://www.gla.ac.uk/researchinstitutes/iii/cvr/aboutus/viruseswestudy/hsv1/
      So yeah just my opinion but finally no more shooting in the dark- drug companies will be all over this and start creating new treatments based on the actual structure of this damn organism, so I'm very hopeful indeed. 
    • AllHailKarma
      By AllHailKarma
      Anyone else actually legit ok? After doing the research, finding out how to keep myself healthy, how to keep this in dormacy, plus seeing how large of a community is on this side of the fence.... like, I'm good. And everyone else really should take the time to read, watch videos, figure out how your own body works with this shit, keep this community close also. We're all gonna be fine.  I'm more annoyed by occasional indigestion honestly.
    • destroyhsv
      By destroyhsv
      If you’ve followed this ASP2151 thread, you may know that I’ve been taking amenamevir (Amenalief) for about two months. In these two months, I have had absolutely no symptoms and no side effects to speak of. I’m ordering blood work soon to confirm that there are no major changes in important biomarkers (kidney, liver, heart, etc.) but I haven’t experienced any side effects that I could observe myself (headaches, diarrhea, insomnia, mood changes etc.) However, there is no data about the effectiveness of valacyclovir + amenamevir on reducing HSV recurrences. Two months of being on this combination is not enough to tell how well it works.
      As a community, what we need is a functional cure. There’s a lot of excitement surrounding pritelivir in this regard. Pritelivir, like amenamevir, is a new drug inhibits the HSV helicase-primase complex. This is a different target than valacyclovir, which is why combining the two has major potential to be a functional cure. If you’ve read Josh Bloom’s article on the possibility of using pritelivir and valacyclovir together as a sort of HIV-like cocktail, then you’ve probably realized this combo is the only way in the foreseeable future that we will have a functional cure.
      Here’s the reality of the situation.
      There will not be a vaccine in the foreseeable future (barring a miracle that allows GEN-003 to continue. I wouldn’t count on that).
      There will not be a CRISPR treatment in the foreseeable future.
      The only HSV drug that is going through clinical trials (past pre-clinical) is pritelivir. That means that aside from amenamevir and pritelivir, there will not be any new drugs on the market for at least ten years.
      You are not getting much help from the pharmaceutical companies. It’s the truth. Many people here are already aware of this. Look at the HSV pipeline. Other than the helicase-primase inhibitors, there is little to no progress being made, and the failure rate is incredibly high.
      If you want, you can wait ten years hoping that the pharmaceutical companies come out with something. The only alternative is to conduct our own trials and gather some data.
      There are plenty of drugs/supplements with studies that have some evidence to support their use in preventing HSV recurrences, but there’s not much consensus on whether they actually improve anything. A lot of them have been tested in animals, but not in humans for the purpose of reducing HSV recurrences. Others have been tested in early-stage trials with very small sample sizes and don’t achieve statistical significance, even if the results are promising:
      L-Glutamine
      Propranolol
      Aspirin & other COX-2 inhibitors Another link
      Lithium
      Lactoferrin
      and plenty more.
      Some people have also speculated that diet changes (ketogenic diet, intermittent fasting, etc.) also lead to dramatic improvement in symptoms. There is plenty of reason to be skeptical about these claims, especially when they only come from a small number of people. The sample size simply isn’t large enough.
      And, of course, there’s a new drug that we know to be a strong inhibitor of HSV replication: amenamevir. Just as famciclovir has the same effect on HSV as valacyclovir, amenamevir has the same effect on HSV as pritelivir. And, as some of you know, amenamevir is approved in Japan and can be purchased online.
      In many cases, valacyclovir by itself is not enough to stop all symptoms/recurrences. Additionally, valacyclovir doesn’t reduce shedding as much as it should. But research has found a strong correlation between number of recurrences and shedding. If we get recurrences down to zero, chances are that shedding is close to zero. At the very least, it means with very high probability that shedding has been significantly reduced.
      Clearly, to achieve a functional cure, valacyclovir is not enough. But when combined it with other drugs/supplements/diets, it could achieve a functional cure or at least eliminate all outbreaks (which all but guarantees a very low level of shedding). Hypothetically, valacyclovir might reduce the average number of outbreaks per year from 3 to 1. Taking amenamevir in combination with valacyclovir might reduce that number to .5. Taking glutamine with amenamevir and valacyclovir might reduce that number to .2 (this is just a hypothetical example). Many of these combos may have a synergistic effect, meaning that using both drugs together would have a stronger effect than the effects of each individual drug combined. And how will we actually figure this out? By doing our own clinical trial.
      We need a significant amount of participants. A trial will have at least sixty participants (more is better, but sixty is doable) for a three month period. I’ve created to gather some basic information about people (nothing personal or potentially identifying. Just things like age, time of diagnosis, frequency of outbreaks in the past year, whether or not they currently take medication. This data will help group the study participants properly) and a spreadsheet for a trial participant to record when they get an outbreak and to briefly describe the symptoms. The group will be split in half, with thirty participants taking only valacyclovir and the other half taking valacyclovir along with whatever we want to study in combination with valacyclovir. Other standard study procedures such as randomization of the groups will be incorporated into the trial. All the participants have to do is take the pills and record any outbreaks they have, briefly describe the symptoms, and write down when they are fully healed from the outbreak.
      At the end of the trial, we will have three months of data for sixty participants. That’s ninety months, or seven and a half years of data, in each group. If the valacyclovir group had a total of ten outbreaks, then the average number of recurrences per year would be about 1.3. If the combo group had a total of five outbreaks, then the average number of recurrences would be about .7. Finally, we test to see if the combo led to a statistically significant reduction in outbreaks compared to the valacyclovir only group. The larger the study group, the more statistically significant the findings will be, which is why a large number of participants is crucial.
      Finally, we finalize the trial by performing any other important data analysis. For example, we could see if there is any correlation between age and efficacy of the treatment. We generate graphs and charts and write a brief “paper” presenting the findings.
      The only one of these trials that would actually “cost” a lot of money would be an amenamevir trial (amenamevir, although available, is pretty expensive). However, if enough people are willing to participate in one, we could get data on what looks to be the most effective treatment that is currently available.
      A trial to assess the effect of any other drug, supplement, or diet would practically cost nothing. Aspirin, glutamine, lactoferrin, and propranolol are widely available and inexpensive, as are many of the other possible treatments, and these trials assume that participants are already taking valacyclovir whether it is covered by their insurance or not. And these trials do not require a major time commitment. The participant will have to verify at the beginning of the trial that they have the study drugs/supplements in their possession (just send a picture and blur out any personal info if there’s a prescription bottle). They take one or two pills a day and record any recurrences. In trials with potential side effects (e.g. lithium), the participant records any side effects. At the end of the study, the participant sends the spreadsheet over. That’s it.
      These studies and data may not be as high quality as that of many clinical trials, but they are certainly useful. By obtaining this data, we give ourselves the ability to treat this disease better than ever before. Instead of shooting fish in a barrel and hoping some supplement works because one person on the internet said it did or because a supplement had an effect in an animal study, you’ll be able to rely on real data from humans. Not only that, but that data will be on a combination of valacyclovir and whatever else is being taken, which there are very few if any human studies on.
      TL;DR: Doing crowdsourced trials on different combinations of valacyclovir and other compounds, we can see which compounds are effective for improving HSV. You can participate, and it is minimally time-consuming and costs next to nothing (unless you want to do an amenamevir trial). Participating will help us gather data to improve our conditions dramatically.
      If you’re interested in participating, please fill out this form: https://goo.gl/forms/Q50PKY8I11tVMsLh2
      I am not interested in anyone’s personal data. These studies are to remain anonymous and I will never ask for or attempt to collect any personal data. The only reason I ask for age in the form is because is a potential variable to account for in data analysis. You do not need to provide your age if you don't want to.
      All communications should be done through this website’s messaging system or using an email that does not link to your identity. You can reach me at honeycombstudy at gmail.com or message me on this site.
      Any questions and/or skepticism are more than welcome.
      Finally, if anyone would like to contribute to this project please contact me! Let’s start taking action.

       
    • HereAndNowLater
      By HereAndNowLater
      Hello world!
      I had my first HSV2 outbreak 8 years ago. 
      The first one is the worst -- the actual outbreak hurts like hell. The outbreak itself was very tiny and localized in a small genital area. However It came with side effects I didn't expect like an acute and intense tingling sensation in my lower back, buttocks, and spread down to my feet/toes. 
      Fast forward years. 
      I rarely get actual outbreaks if ever. 
      But I do experience that intense nerve pain I remember that comes before an outbreak manifests as a skin lesion.
      So now the outbreaks don't happen, but the prodrome pre-tingles happen often. Except now those piercing sharp tingles aren't just perceptible in the aforementioned areas. I feel it all over my body intermittently - neck, shoulders, arm, yes leg and lower back, foot, etc..
      To emphasize, I never experienced any chronic pain remotely similar to "herpes tingles" pre- first HSV 2 outbreak. 
      Several Questions:
      Does this pain sound familiar to you? Has it migrated outside of where it was when you first had an outbreak? When I bring this up to multiple doctors, I'm baffled that they have no idea what I'm talking about. Or don't see the connection between the nerve(?) /lymph node (?) pain / neuralgia/ paresthesia and HSV.  Every time I see a "Lyrica" commercial for fibromyalgia I think to myself, "well this is fucking it. this is what I'm feeling/experiencing in my body." Is there a link between fibromyalgia and herpes? I wonder how many patients diagnosed with fibromyalgia have either HSV 1/ HSV 2/ shingles/ varicella-zoster viruses or something related? It seems to me there is a there there. But I also feel I'm being gas lit by the world and that in general researchers / HCPs are too "embarrassed" to even commit to research around the "not talked about" symptoms of HSV; or even HSV in general.  How can herpes be so "common" and yet not a single medical professional is conversant in the totality of the disease or specializing in it? >_< Not related, but where can I purchase acyclovir cream? That stuff is like contraband in the USA lol.  ugh this country sucks in this arena. 
    • Ribbon35
      By Ribbon35
      Since May I have been taking Valtrex. At first it was 500mg once a day then it increased to 1000mg once a day in June after frequent outbreaks persisted. I've had a total of 9 outbreaks since May and was diagnosed with hsv2 in March of this year.  The past three weeks I've had severe dizziness, especially when lying down and getting up in the mornings. Today my doctor suggested taking acyclovir 400mg twice a day. Has anyone switched from acyclovir to valtrex and experienced better results/less breakouts?
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    • Burty
      Coming back to report that after vaccinations in May and July, today I have one vesicle. Called the doctor and will report back later. Slightly pessimistic at this point. 
    • Cariad
      I think I need to treat this as an ocd thought (that I've got herpes) and not check myself compulsively, not seek constant reassurance from doctors and the internet, just try and forget about it. Re disclosure, I would tell future partners that i could have hsv but I don't know, all the visual examinations and tests I've had have come back negative but there's still a possibility that i have herpes. Then they can decide whether to take the risk. I always assume someone is positive for everything unless there are tests to prove otherwise. I don't do casual relationships so always get a full sexual health screening with my new partner so we can both be safe. But they could have herpes and not know as it's not routinely checked for. It's a risk for all parties involved. I spoke to herpes.org.uk helpline and Marion told me that blood tests are routinely bringing up false positives/negatives and that having the virus doesn't predict when and where you're going to have an ob. I therefore wouldn't trust the result of the test and would be repeatedly getting tested, as I did when my hiv ocd was really bad. That was a hugely stressful and anxious time and I don't want to go through that again!! Especially for a virus that can't kill you!! So I think I'm going to have to live with the uncertainty of having herpes obs and avoid sexual contact whenever I feel sore down below if/when I'm in a relationship.  Being on this forum is just exacerbating my Ocd, so I think that I should stop posting as it's reassurance-seeking. Wishing you all the best and thank you all for your help, advice and support. Remember - it's just a virus that billions of people have and doesn't make us dirty or unworthy of love or a good life. Stay safe and well xx
    • WilsoInAus
      And I’ll help you up until the second coming. I think this is an unhealthy dose of imaginitis as far as herpes is concerned. Wouldn’t you agree?
    • WilsoInAus
      Yes man that’s correct. I mean we don’t really want more people in the delusional room with mirrors that see nothing, do we?
    • WilsoInAus
      There’s nothing visually or in what you describe that is suggestive of herpes. See your doctor if you have concerns, there’s plenty of things on the list of possibilities here.
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