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Drug repurposing: omeprazole increases the efficacy of acyclovir against herpes simplex virus type 1 and 2

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Posted (edited)

Check out this article on repurposing Omeprazole (PRILOSEC).  Taken with Acyclovir it increases the efficacy of acyclovir. Note all this was done in Vero (petri dish).  But since Prilosec is well tolerated in most it may be something to look into to see if it can help control outbreaks. Both medications would need to be taken at the same time, Prilosec and Acyclovir or Valacyclovir.  I'm getting some Prilosec today!  


Edited by TCBH
wrong info

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Omeprazole half-life is 1-1.2 h, while acyclovir half-life is 3 h, you would need to take it much more often.

Furthermore, there are risks associated with long term consumption.

But it is interesting for short term usage like when you are having an OB.

If you are on suppressive AV treatment, when having an OB you could try omeprazole instead of ramping up the acyclovir dose.


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Try a Lysine supplement for cold sores

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