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allhereto

High dose (2grams/day) Valtrex suppressive therapy -long term

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allhereto

I have constant cold sore outbreaks, and I've tried natural remedies with limited success (olive leaf extract, lysine supplements, zinc, and vit. c). I have also been on a suppressive dose of Valtrex for 6 months now - 500mg twice daily - still having back to back outbreaks. I  recently asked my doctor to let me increase my Valtrex dosage to 1,000mg twice daily for long-term suppression.  Is there any research to support a dosage this high every day/longterm for more effective outbreak control for oral or genital hsv?

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WilsoInAus

Unfortunately the effect tops out at about 1g per day. Any excess is typically redundant.

What and where are these outbreaks? 

The focus probably needs to be on a form of you being immunocompromised. 

 

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hellohello111
6 hours ago, allhereto said:

I have constant cold sore outbreaks, and I've tried natural remedies with limited success (olive leaf extract, lysine supplements, zinc, and vit. c). I have also been on a suppressive dose of Valtrex for 6 months now - 500mg twice daily - still having back to back outbreaks. I  recently asked my doctor to let me increase my Valtrex dosage to 1,000mg twice daily for long-term suppression.  Is there any research to support a dosage this high every day/longterm for more effective outbreak control for oral or genital hsv?

Have you asked your doc for Denavir cream? It’s a topical for cold sores and is pretty awesome. You take that coupled with valtrex and you should be good. 

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hellohello111

Also, let’s dig a bit deeper. What’s your diet like? Exercise? Age? Are you immune compromised? What HSV do you have? How long have you had it? What did you do before valtrex? This will help

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allhereto

Thanks, guys for the responses! I'm 38 years old, not immune compromised, and I have hsv 1 - cold sores under my nose and all around my lips...usually one blister per outbreak, and I never had outbreaks until about 6 years ago....although I know I was infected prior to that.  I also get genital HSV 1 outbreaks about twice/year. I eat fairly healthy (low carb), I do drink whey protein shakes, but the lysine/arginine ratio seems to be good; I also avoid common trigger foods. I walk about half an hour 4 days/week, and do yoga for about an hour once a week.  My  stress level is really high now due to my job and a recent break up, so I'm sure that is a contributing factor....I've been up to 1 year between outbreaks when my stress level was lower. Before Valtrex, I used Acyclovir 400 mg twice daily for suppressive therapy, and I can't really tell a difference in effectiveness. I did seem to have success with Thorne Olive Leaf extract 500 mg twice per day - helped keep me outbreak free for around a year - without any anti viral medication, but I had a genital outbreak after about a year and stop using it. Lysine at 3 grams per day may helped some, but didn't seem strong enough for me. Abreeva seems to help speed up healing time, but isn't particularly effective. I haven't tried Denavir cream....I may ask for that next. Anyways, thanks for the tips!

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