Skin condition my ass

[MichelleJ12]

When I was first diagnosed almost 4 years ago, I was told it was a minor skin condition and all I needed to take was a Valtrex and everything would be fine. Nobody told me that this virus would wreck my nerves! I have nerve pain that has been progressive since I was diagnosed with herpes. The sad part is most doctors aren’t aware of this and downplay your symptoms.  There is a community of us out there that are suffering with extreme nerve pain from this virus. I miss my health. I miss having a pain free day. 

Rant over!

[WilsoInAus]

You can be quite confident that the nerve pain you refer to is not being caused by HSV1/2.

Do you have herpes HSV 1 or 2?

[Ian]

Just everyone on here suffers from some sort of never pain and the virus lives in a nerve....

But sure you must know best as always.

[WilsoInAus]

2 hours ago, Ian said:

Just everyone on here suffers from some sort of never pain and the virus lives in a nerve....

But sure you must know best as always.

But that is the point, the virus LIVES forever in the nerve cells. HSV 1/2 does not injure or damage nerves - it has no known mechanism for doing do, indeed HSV 1/2 encourages healthy nerve growth.

There are numerous issues that cause nerve pain for people. In rare circumstances some of these can relate for example to the immune response to HSV 1/2. 

This isn't what I know, this is simply scientific facts from people who have actually studied HSV 1/2.

Do you have a purpose for being on this website, I hope it is helping you and adding to your scientific knowledge. Do you have herpes (HSV 1/2)? What ailments do you have?

[hk81]

that's quite wrong. If you want, cite the articles that say that HSV protects neurons and nerves from damage.

You will find in many many articles that HSV interferes with the repair mechanism (DNA damage response (DDR)) of the neurons

https://www.frontiersin.org/articles/10.3389/fnagi.2016.00242/full

"Here we show that HSV-1 productive infection in cortical neurons causes the accumulation of DNA lesions that include both single (SSBs) and double strand breaks (DSBs), which are reported to be implicated in the neuronal loss observed in neurodegenerative diseases"

You can search many more articles by searching "HSV DNA Damage Response neurons".

 

HSV causes the disruption of the sensory nerves in the cornea, differently from your hypothesis. One common test that is performed in these cases is the blink reflex

https://journals.asm.org/doi/full/10.1128/JVI.01146-14

"Loss of blink reflex (BR) in human HSK is common and due to a dramatic retraction of corneal sensory nerve termini in the epithelium and the nerve plexus at the epithelial/stromal interface."

 

And the further damages during reactivations in the nerves is documented.

https://jamanetwork.com/journals/jamaneurology/fullarticle/795486

"Radiculopathy caused by HSV-2 infection typically affects the lumbar or sacral nerve roots and is often recurrent. In addition to radicular pain, paresthesias, urinary retention, constipation, anogenital discomfort, and leg weakness may be observed."

[WilsoInAus]

@hk81 I am not sure what we have done to deserve your scientific incompetence. Actually I am pretty sure it is not that, simply your fantasy that somehow HSV-1 is causing an unbelievable array of symptoms for you and this does not have credence on this website.

I made the statement "HSV 1/2 does not injure or damage nerves - it has no known mechanism for doing do, indeed HSV 1/2 encourages healthy nerve growth."

This statement is entirely correct. There is no need to cite any articles on this as they are readily found as I am sure your extensive research identified. HSV 1/2 promotes 'nerve growth factor'. If you look up that term and actually do a bit of research then maybe you'll learn something, but hey, that hasn't happened in years - but here's hoping seeing it is Christmas and all that a leaf can be turned!

Your incoherent assembly of articles has nothing to do with the topic... of whether HSV 1/2 causes nerve pain by damaging sensory nerves!

The first article is about a correlative and as yet unverified link between HSV-1 in the brain and degenerative brain disease. This is an active theory, unverified as mentioned, and not the strongest theory. Time will tell what is right on this topic. For now though, this has nothing to do with nerve pain from damaged nerves in the genital region for example - which was what the OP was posting about.

The second article deals with issues of herpes keratitis. Note that I made the additional comment "There are numerous issues that cause nerve pain for people. In rare circumstances some of these can relate for example to the immune response to HSV 1/2." This is exactly what this article is about.

The third article deals with radiculopathy. This is also undetermined as to the cause, most probably immune related. HSV-2 is sometimes present in CSF and antivirals bring some relief (but not always). This does not involve nerve damage of HSV-2 infected nerves. This is also rare and impacts people with and without herpes. 
 

[hk81]

the first article is one of many articles stating that HSV blocks the DNA damage response in neurons. And that is one of the many ways HSV alters cells to be able to maintain latency. It doesn't have anything to do with the unproven link with Alzheimer's. The impact of HSV to DDR is described in many many articles.

Whether HSV directly cause an injury to a nerve, or the immune system response causes it due while attacking the virus, it is a minor detail. Both coexists in the body and the presence of HSV is the sole reason that trigger a "immune-mediated" nerve damage. Those are details that won't change the fact that ppl suffer from nerve pain after a HSV infection.

The third article states the same thing: an active HSV infection attracts immune cells towards the nerves and CSF, causing neuropathies.

 

The OP wrote " I have nerve pain that has been progressive since I was diagnosed with herpes." and you replied "You can be quite confident that the nerve pain you refer to is not being caused by HSV1/2. "

That's misinformation and the usual attempt to confuse people with their symptoms, denying correlations that are widely described in the medical database.

 

Now make a publication writing "people are not dying of Covid19. They are dying because of the immune reaction".

I'm sure they will give you a nobel prize

[WilsoInAus]

@hk81 yes the OP wrote " I have nerve pain that has been progressive since I was diagnosed with herpes."

As you well know, none of the random collection of papers you cited above support 'progressive' genital nerve pain from herpes - they aren't actually that relevant at all (some of them refer to mice studies!).

To suggest that a person might have nerve pain from HSV-2 genitally based on your own biases and misinterpretation when you know full well there is a 99% chance plus it is not is culpable.

This sort of behaviour is not tolerated here and you have been warned several times already in this regard. Please remain within reddit where you can fantasise and develop conspiracies all you like.