Jump to content
World's Largest Herpes Support Group
LeftCoast

Moving on. What’s happening with HSV529 vaccine?

Recommended Posts

LeftCoast

When do Phase 2 trials for Sanofi Pasteurs HSV 529 vaccine start? 

Share this post


Link to post
Share on other sites
justanothersufferer
On 6/13/2018 at 10:13 AM, Freefalling87 said:

That link is referencing phase 1. They have not yet released the results of phase 1 (that I am aware of). 

Correct!

Share this post


Link to post
Share on other sites
Voyager2

The first HSV529 phase 1 safety trial of 69 subjects ran from July 2013 to March 2017,

https://clinicaltrials.gov/ct2/show/NCT01915212

and evidently led to the vaccine being pronounced safe.

But then a second phase 1 safety trial (as referenced above in this thread) was launched in November 2015 with 10 subjects and is supposed to be completed in December 2018 - which is 6 months from now.

So they clearly want to be doubly sure this live vaccine is safe before moving on to phase 2. It's a shame it's taking so long but at least they haven't given up.

If the very promising Einstein and trivalent vaccines also find their way into clinical trials, we'll have a real horse race.

 

Edited by Voyager2

Share this post


Link to post
Share on other sites
Shandawgs
12 hours ago, Voyager2 said:

The first HSV529 phase 1 safety trial of 69 subjects ran from July 2013 to March 2017,

https://clinicaltrials.gov/ct2/show/NCT01915212

and evidently led to the vaccine being pronounced safe.

But then a second phase 1 safety trial (as referenced above in this thread) was launched in November 2015 with 10 subjects and is supposed to be completed in December 2018 - which is 6 months from now.

So they clearly want to be doubly sure this live vaccine is safe before moving on to phase 2. It's a shame it's taking so long but at least they haven't given up.

If the very promising Einstein and trivalent vaccines also find their way into clinical trials, we'll have a real horse race.

 

Starting to get abit of hope thank you for this post! Finger crossed

Share this post


Link to post
Share on other sites
HerpesDumbAf

So this is just preventing not even curing? I’m so done with the science world at this point 

Share this post


Link to post
Share on other sites
Heal World

We all leave messages on Facebook to Bill Gates, Sun Yatsen Softbank Group, Alibaba Mayun, and other entrepreneurs, and send them emails, hoping they can help us. I know that my own personal power is limited, and I hope that each of us can take positive actions so that we can get their help within a short time.

Share this post


Link to post
Share on other sites
IamPositive
On 6/22/2018 at 3:13 AM, Shandawgs said:

Starting to get abit of hope thank you for this post! Finger crossed

Finger crossed!!! At least the big name like Sanofi Pasteur won’t have difficulty regarding finance. I do really hope this vaccine would be success...

Share this post


Link to post
Share on other sites
Hockeyawesome1
On 6/21/2018 at 1:49 AM, Voyager2 said:

The first HSV529 phase 1 safety trial of 69 subjects ran from July 2013 to March 2017,

https://clinicaltrials.gov/ct2/show/NCT01915212

and evidently led to the vaccine being pronounced safe.

But then a second phase 1 safety trial (as referenced above in this thread) was launched in November 2015 with 10 subjects and is supposed to be completed in December 2018 - which is 6 months from now.

So they clearly want to be doubly sure this live vaccine is safe before moving on to phase 2. It's a shame it's taking so long but at least they haven't given up.

If the very promising Einstein and trivalent vaccines also find their way into clinical trials, we'll have a real horse race.

 

What type of vaccine is this? A therapeutic vaccine? Or is it a functional cure where it stays dormant?

Share this post


Link to post
Share on other sites
IamPositive
6 hours ago, Savannah069 said:

What is this vaccine supposed to do..

Keep the healthy one immune to our virus/prophylactic.

Share this post


Link to post
Share on other sites
IamPositive
6 hours ago, Hockeyawesome1 said:

What type of vaccine is this? A therapeutic vaccine? Or is it a functional cure where it stays dormant?

I guess it would be like Current HPV vaccination.. to protect the uninfected person has ability to combat the virus and stay clean.

Share this post


Link to post
Share on other sites
HerpesDumbAf
5 hours ago, IamPositive said:

Keep the healthy one immune to our virus/prophylactic.

It’s funny how HIV the actual death sentence isn’t even stigmatized as this which is blowing me

Share this post


Link to post
Share on other sites
Visitorette
2 hours ago, Savannah069 said:

It’s funny how HIV the actual death sentence isn’t even stigmatized as this which is blowing me

You're right. They feel more sorry for them while they did the same thing as us to aquire it; having sex.

Share this post


Link to post
Share on other sites
Zero6283

It does bug me...... hiv has no risk of transmission and normal life expectancy if caught early and on medication....... hsv has literally nothing to prevent transmission.......

Share this post


Link to post
Share on other sites
brookeb300

I think they r so scared of aids that they are really trying to cure it while herpes they look at as almost a joke

Share this post


Link to post
Share on other sites
HerpesDumbAf
2 hours ago, Visitorette said:

You're right. They feel more sorry for them while they did the same thing as us to aquire it; having sex.

 

1 hour ago, Zero6283 said:

It does bug me...... hiv has no risk of transmission and normal life expectancy if caught early and on medication....... hsv has literally nothing to prevent transmission.......

 

12 minutes ago, brookeb300 said:

I think they r so scared of aids that they are really trying to cure it while herpes they look at as almost a joke

The fact that catching HERPES is high risk for AIDS you would think there would be a cure by now or something to stop transmission I’m just saying 

Share this post


Link to post
Share on other sites
IamPositive
6 hours ago, Savannah069 said:

It’s funny how HIV the actual death sentence isn’t even stigmatized as this which is blowing me

So agree with you.. just because theoretically we could live longer than HIV patients.. but it’s the “theory”... the reality.. I believe so many of us want/already end their life because of this “creep”y virus. So we ain’t get any longer life expectancy to be honest...

Share this post


Link to post
Share on other sites
IamPositive
4 hours ago, Visitorette said:

You're right. They feel more sorry for them while they did the same thing as us to aquire it; having sex.

:sob:

Share this post


Link to post
Share on other sites
MikeHerp
On 2/2/2019 at 5:33 PM, oneday said:

Anything from Sanofi on their vaccine?

I think the trial finished a couple of weeks ago.  I don't know when or whether they'll publish results.  

Share this post


Link to post
Share on other sites
jeraldpeabody

@MikeHerp have you been following the HSV-2 ΔgD-2 research at all? Apparently, they're working with a company on it but I can't find any further information on it. Wondered if you might have any further info?

 

Edited by jeraldpeabody
updated video link

Share this post


Link to post
Share on other sites
StayingUpbeat

The Betsy C. Herold, MD delta GD-2 vaccine is being pursued by a company called x-vax

https://x-vax.com/

preview-chat-x-vax_pipeline_graph-01-102

"We’ve begun to transfer the vaccine ∆gD-2 from the research lab to manufacturing facilities for further development and production, and to prepare for a Phase 1 clinical study."

Share this post


Link to post
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.


  • The Hive is Thriving!

    • Total Topics
      69,563
    • Total Posts
      468,604
  • Posts

    • viralfrog
      I would not be the first one, plenty of others here on the forum who get recurrent OBs despite heavy doses of antivirals. The blisters appear exactly in/around the spot where I had my first OB 4 years ago, plus all the symptoms I have are those commonly described as HSV-2 symptoms. In my opinion, it's a clear case.  But your suggestion is definitely an option that should not be ruled out. I'll wait until I get a bad enough OB again so I can go get another swab test. The outbreak needs to be bad enough to be able to break the blisters to get the liquid from inside right? I recall hearing something like this when I got tested years ago. The doctor used a swab that had tiny needles on it that would pop the blisters open. Do you know if this is right, i.e. you will not get a positive swab just from a mild OB / redness? 
    • jreemi
      90% elimination of the latent virus in thr ganglia probably will be a functional cure. Sure the small remaining amount can reactivate, but thete is a viral load threshhold for transmission. More than likely that won't be enough to cause transmission, or enough shedding for transmission. Damage enough of the latent virus and we are good to go. There is already a Crispr trial on humans going on right now https://newatlas.com/crispr-trial-underway-vertex-gene-therapy/58643/ So we are just waiting on Keith Jerome's lab and Excision Biotherapeutics to begin their trials. I've beem following Crispr for years now, and it keeps gettimg more accurate. I believe researchers at Duke have recently made a big breakthrough on accuracy, by changing the level of regulation instead of cutting DNA. I wonder if these labs collaborate with others such as Jerome's?
    • WilsoInAus
      No need to be tired at all, I'm sorry of you cannot accept the facts surrounding testing, but here they are. Your note is full of inaccuracies so let's iron those out. I don't need you to believe anything, I am just putting the facts out there. Here's a few studies: https://jcm.asm.org/content/37/5/1632 Here we have 29 patients with recent HSV-2 infection... 100% turned positive, 0% false negatives. https://jcm.asm.org/content/36/3/845/figures-only Here we have over 1,000 positive samples from people who have swabbed positive and compared to three different blood tests - over 95% accurate. https://jcm.asm.org/content/26/4/662?ijkey=9ebe349f98ed94f019ed788604c8fa19864a2c7e&keytype2=tf_ipsecsha Here we have 76 people who swabbed positive, the Westernblot detected 99% and an immunoblot 96%. Can you elaborate what is vague about these items of research. I'm sure now you'll want to review the references to these papers where you'll find even more. Some of them are in easy text for the beginner. So you stand corrected, it is in fact your comments that are spreading misinformation. That is not tolerated on this website. Also what nonsense that people do not get lesions to swab upon infection? Where did you read that? Hello Dolly? I'm afraid it is back to the books for you to do some more research before having such a rambunctious spew like above. STOP IT - we are all tired of your unsubstantiated drivel. This is 2019 we want something tangible, something real, something sound and wholesome and not drooling rants equal of the park bench antics of the drunks at 2am Sunday morning! I will NEVER stop because no matter how immature, how bombastic, how fantastic, how inaccurate, how frivolous, how false the spew that ends up on this website - the TRUTH will always be the light, the love, the guidance, the deliverance and the justice... no matter how many capitalised swear words are thrown!
    • Talx2520
      I took an IgG blood test 6 months after the episode. HSV-2 was negative (less than .91) and HSV-1 was high at 3.18
    • RainyDay2
      My comment was about THE BLOOD TEST!  You’re 95-100% accuracy for it?  Garbage.  Pure garbage.  You might as well have pulled that number out of your ass. Google search HIV accuracy... almost every medical site will tell you 4th generation HIV testing is as close to 99.9% percent you can possibly get after a certain period of elapsed time.  They will pretty much GUARANTEE you that you are indeed negative if you have a negative test. That defined certainty of accuracy WILL NOT AND CAN NOT be found for HSV blood tests.  You get vague descriptions of it’s accuracy from almost every site you visit.  NO CERTAINTIES.  Thousands of us on these forums KNOW the test isn’t accurate. When your score is between 1.1 and 3.5, this could be a false positive.  Certain sites list almost 1 in 2 tests can be false positives.  50 fucking percent!! And you want me to believe the test is 95-100% accurate? How come so many sites also seem to dance around the possibility of false negatives?   All that isn’t necessary in HIV testing.  Because if YOU DO get a low positive, the confirmatory HIV test checks for the actual VIRUS in your system.   And there are almost NO FALSE NEGATIVES.    NO HSV BLOOD TEST CAN DO THAT! Not even the Western Blot.  At the end of the day, it’s just a more detailed look at antibodies.  And many sites will tell you a “small” number of people may never develop. How small are we talking???? That can be any number.   Trash. And again, a large margin of people with herpes DO NOT GET LESIONS to be swabbed.  Google tells you that.  If majority of herpes infected have nothing to swab,  well that pretty much makes PCRs and cultures worthless for the most part doesn’t it?  If there is nothing to swab after a year, in your words, you are clear of herpes. BULLSHIT! So Wilso, just stop it.  You have never done scientific testing in a lab yourself on herpes. You are not a doctor.  You are constantly telling people false information.  Assuring them of promises you have no authority to make.  I’ve seen you do it time and time again.  Do you have regrets???????????  Im tired of your lies.  
×
×
  • Create New...

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.