Jump to content
World's Largest Herpes Support Group
dmor24

Abandoned Genital Herpes Vaccine GEN-003 Found to Reduce Lesions

Recommended Posts

dmor24

Share this post


Link to post
Share on other sites
GotMeAtLast
Posted (edited)

Am I reading it right... They are gearing up for PHASE 3!??!

Maybe I am dreaming...

Despite positive phase 2 trial results, Genocea Biosciences, Inc, which developed GEN-003 decided to pull the plug on the vaccine last year. GEN-003 now appears under the “Partnering” section of Genocea’s website and is listed as “a Phase 3-ready investigational immunotherapy for the treatment of genital herpes infections.”

Edited by GotMeAtLast

Share this post


Link to post
Share on other sites
dmor24

They are looking for partners. I emailed them last month and their response was:

Thank you for your interest in GEN-003, Genocea’s investigational immunotherapy aimed at boosting the immune system to better control the genital herpes virus and reduce the number and duration of outbreaks (lesions).

 Genocea has successfully completed phase 2 clinical trials on GEN-003.  However, as a consequence of a strategic shift to immuno-oncology, the company has ceased activities on the GEN-003 program.  We are actively pursuing strategic alternatives in order to identify a partner to advance the program.

Share this post


Link to post
Share on other sites
GotMeAtLast

I wish they would released their research to the wild for someone else to pick up if finding additional partners fail.

Share this post


Link to post
Share on other sites
Shandawgs

Stupid question here, I have HSV-1 will this also help in my case if successful? 

Share this post


Link to post
Share on other sites
Southwestrancher

Doesn't sound like a full cure anyway. To me that's no good. Any shedding at all is no good in my opinion. There's much better stuff going on. CRISPR, etc.

Share this post


Link to post
Share on other sites
SCG

66% reduction in viral shedding and 65% reduction in lesions...how did they not get funding? 

That's by far the most successful herpes vaccine ever made. 

Pretty messed up.  

Share this post


Link to post
Share on other sites
undertsun
2 hours ago, SCG said:

66% reduction in viral shedding and 65% reduction in lesions...how did they not get funding? 

Where did you found those results?

I remember when they published phase 2b results, placebo had better shedding reduction.

Share this post


Link to post
Share on other sites
f*ckedOver

@Southwestrancher

With all due respect any positive news in the light of this virus is damn good news. I would gladly take something that would reduce symptoms by 2/3 for both shedding and lesions. I get nerve pain from this shit in my hands and now it's beginning in my feet. Anything to stop this monster would be great. 

Let's not forget that in 30% of the participants they had NO SYMPTOMS FOR 1 YEAR straight - what if you took that vaccine and that's what happened to you ? I bet you would be loving love about a 1000000000000 million times more.

I can't help but wonder what taking this vaccine would be like in combination with anti-viral therapy would be like ? For all we know maybe that combo would reduce the shedding rate so that it cannot be passed to another person.

HIV uses a cocktail and the CDC has came out and said HIV cannot be passed to others when you follow the REGIME 100%....just an example.  They found no evidence of virus in the blood of people taking the regime.....(last time I looked on the CDC for this information was about 3 months ago, so not sure if anything has changed ) .

Yes the ideal vaccine would do just what you pointed out and this vaccine is also a good indicator to where the scientists are headed....success. CRISPR has already shown to have hurdles and well, I don't know how much you actually know about the HSV virus, but it's actually the holy grail of viruses - it's essentially a virus master with many great features - hence why we still don't have a cure. I am not trying to sound rude or condescending, I am still reading and learning when I can. I love science but I hate this f*cking virus. 

Share this post


Link to post
Share on other sites
Blenescar
13 minutes ago, f*ckedOver said:

@Southwestrancher

With all due respect any positive news in the light of this virus is damn good news. I would gladly take something that would reduce symptoms by 2/3 for both shedding and lesions. I get nerve pain from this shit in my hands and now it's beginning in my feet. Anything to stop this monster would be great. 

Let's not forget that in 30% of the participants they had NO SYMPTOMS FOR 1 YEAR straight - what if you took that vaccine and that's what happened to you ? I bet you would be loving love about a 1000000000000 million times more.

I can't help but wonder what taking this vaccine would be like in combination with anti-viral therapy would be like ? For all we know maybe that combo would reduce the shedding rate so that it cannot be passed to another person.

HIV uses a cocktail and the CDC has came out and said HIV cannot be passed to others when you follow the REGIME 100%....just an example.  They found no evidence of virus in the blood of people taking the regime.....(last time I looked on the CDC for this information was about 3 months ago, so not sure if anything has changed ) .

Yes the ideal vaccine would do just what you pointed out and this vaccine is also a good indicator to where the scientists are headed....success. CRISPR has already shown to have hurdles and well, I don't know how much you actually know about the HSV virus, but it's actually the holy grail of viruses - it's essentially a virus master with many great features - hence why we still don't have a cure. I am not trying to sound rude or condescending, I am still reading and learning when I can. I love science but I hate this f*cking virus. 

I feel the same with what you stated as well based on my research there are about 7 possible vaccines out there and only one of them is currently in clinical trial. My belief is in there is definitely a cure within the next decade or two based on two major factors imo. First the curing of HIV and secondly the efficiency of crispr and gene editing done in china this year.

Share this post


Link to post
Share on other sites
valleynovascotia

I don't care what it is cure, therapeutic cure or treatment  as long as i don't have to say "ï have herpes'' then i'm all for  it but it sounds like I would still have too disclose with this. We deserve better than being stuck with this virus for life its both painful as hell physically and mentally plus for some of us it wrecks every potential relationship herpes is more than harmless for me.

Share this post


Link to post
Share on other sites
HerpesDumbAf

If it can be treated like any other std and be cleared away like I don’t understand because with chlamydia and gonorrehea like you can cure it and still catch it tf I wish it was like that then the dumb ass pharma can still get their money

Share this post


Link to post
Share on other sites
Divon
6 hours ago, HerpesDumbAf said:

If it can be treated like any other std and be cleared away like I don’t understand because with chlamydia and gonorrehea like you can cure it and still catch it tf I wish it was like that then the dumb ass pharma can still get their money

Well obviously herpes wouldn´t end just because there came a cure either. Especially not if that cure is a costly and time demanding procedure. It´s just that people love conspiracy theories and love saying things like "We are not getting cured because the world is corrupt."

Share this post


Link to post
Share on other sites
HerpesDumbAf
15 minutes ago, Divon said:

Well obviously herpes wouldn´t end just because there came a cure either. Especially not if that cure is a costly and time demanding procedure. It´s just that people love conspiracy theories and love saying things like "We are not getting cured because the world is corrupt."

But the thing is I feel people with HIV is spending more money than people with herpes because they really have to take daily medication to not turn it into aids n die , like I see on Twitter that said “people think hiv is a death sentence” which it is if the daily medication isn’t took DAILY. We don’t have to take the medication. I feel this virus is bacterial in a way it may sound silly because you can’t die from this or any other sti which is why I’m still confuzzled ok why there isn’t a cure for this just like a bacterial infection, yea I understand it’s complicated but it’s just a matter of time before we get fed up and there’s chaos 

Share this post


Link to post
Share on other sites
35hope
17 minutes ago, Divon said:

Well obviously herpes wouldn´t end just because there came a cure either. Especially not if that cure is a costly and time demanding procedure. It´s just that people love conspiracy theories and love saying things like "We are not getting cured because the world is corrupt."

i see it more like government and FDA wants to get their kickback befor a company becomes rich when they produce a cure for some disease, thats how i feel about it, honestly even small companies can do clinical trials safely on their own with tens of thousands of dollars instead of tens of millions. 

Share this post


Link to post
Share on other sites
Divon
Just now, HerpesDumbAf said:

But the thing is I feel people with HIV is spending more money than people with herpes because they really have to take daily medication to not turn it into aids n die , like I see on Twitter that said “people think hiv is a death sentence” which it is if the daily medication isn’t took DAILY. We don’t have to take the medication. I feel this virus is bacterial in a way it may sound silly because you can’t die from this or any other sti which is why I’m still confuzzled ok why there isn’t a cure for this just like a bacterial infection, yea I understand it’s complicated but it’s just a matter of time before we get fed up and there’s chaos 

What you are stumbling upon is that you are actually questioning whether herpes is an uncureable infection. The answer is, it is not. Your body cures it every time but it has the ability to hide where it can´t be detected or harmed by the immune system and then strike again. Many viruses have similar attributes but they tend to reoccur less often, which in turn removes their stigma. HIV however is incureable in it´s truest form and yes HIV is waaaay more expensive to treat. When you look at std databases HIV will go under "Very high" as treatment cost while herpes will go as low. I might add that this is why I keep saying that NO herpes does not need to be CURED, it only needs to be suppressed and if you think that achieving that is unreachable for science, you are delusional.

Share this post


Link to post
Share on other sites
HerpesDumbAf
33 minutes ago, Divon said:

What you are stumbling upon is that you are actually questioning whether herpes is an uncureable infection. The answer is, it is not. Your body cures it every time but it has the ability to hide where it can´t be detected or harmed by the immune system and then strike again. Many viruses have similar attributes but they tend to reoccur less often, which in turn removes their stigma. HIV however is incureable in it´s truest form and yes HIV is waaaay more expensive to treat. When you look at std databases HIV will go under "Very high" as treatment cost while herpes will go as low. I might add that this is why I keep saying that NO herpes does not need to be CURED, it only needs to be suppressed and if you think that achieving that is unreachable for science, you are delusional.

Hell just treat the transmission like shit tbh like think about it I mean if they make a vaccine that’s like 65% reduce shedding then taking the meds can reduce it more if you’re having sex like I’ll be happy with that 

Share this post


Link to post
Share on other sites
Divon
10 hours ago, HerpesDumbAf said:

Hell just treat the transmission like shit tbh like think about it I mean if they make a vaccine that’s like 65% reduce shedding then taking the meds can reduce it more if you’re having sex like I’ll be happy with that 

yes of course but gen 003 is far from proven to reduce as much as 65%.

Share this post


Link to post
Share on other sites
HerpesDumbAf
17 minutes ago, Divon said:

yes of course but gen 003 is far from proven to reduce as much as 65%.

): well I need one of these organizations to hurry like I really wish I caught this at an older age like 25 than 18 rn

Share this post


Link to post
Share on other sites
Divon
On 7/12/2018 at 12:26 PM, HerpesDumbAf said:

): well I need one of these organizations to hurry like I really wish I caught this at an older age like 25 than 18 rn

yeah thats what I keep telling myself too. I cant even begin to describe how little I would care about this if I just got it at around 40.

Share this post


Link to post
Share on other sites
HerpesDumbAf
24 minutes ago, Divon said:

yeah thats what I keep telling myself too. I cant even begin to describe how little I would care about this if I just got it at around 40.

Right life damn near over idec if I got is after 21 like ughhhhh I could have got this at 22 I would be fine 

Share this post


Link to post
Share on other sites
GotMeAtLast
1 hour ago, Divon said:

yeah thats what I keep telling myself too. I cant even begin to describe how little I would care about this if I just got it at around 40.

It still sucks for those of us in our 40's. Granted you will have to deal with it a lot longer than I, but it still sucks.

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

Advertisement

Try a Lysine supplement for cold sores

  • The Hive is Thriving!

    • Total Topics
      67,716
    • Total Posts
      451,066
  • Posts

    • SillyGirlMel
      I agree, but funny thing is that I didn't check to see what they tested for until after I got HVS2, and then I looked at the testing panel and realized that testing for HVS2 is not required for this industry, it's not something they disclose to you, it's something you have to figure out for yourself.  There isn't an orientation or anything for this field of work and many girls are 18, just out of high school, some still in, when they enter... It's something I'm trying to figure out how to change... Personally as a solo and girl/girl only performer, I see a lot of good in the adult industry if they just tweaked things such as testing for HSV2, or disclosing that they don't beforehand.
    • HerpesDumbAf
      Okay so I want some physical pains, emotional pains, psychological pains, etc to how this has affected you! I’m doing this so I can have some background on not just me but for EVERYONE who experiences chronic pains or mental pains or more when I go meet with the head GYN to talk about and I quote    “You are certainly welcome to schedule an appointment with one of the other GYN providers who are in clinic this month especially if you have questions or concerns about your own health. I believe Fadyia was trying to connect us as you raised concerns about areas affecting all students in which case I’d be happy to meet and discuss when I return. J “    but the only physical pain I’ve experienced was severe nerve pain and blisters but they’ve healed and never returned , and the only mental pain i experience is when knowing you’re the “only one who has it” but I want to hear from YOU guys so I can have some backbone To why this should be talked about more when she returns. I mean everyone says we should give back to the community. So type the problems/concerns below and I’ll check them and when she returns I’ll state them! 
    • HerpesDumbAf
      Well hell if they don’t test then that’s the risk everyone takes   
    • SillyGirlMel
      I recently had to build up courage to disclose, but it was after I already had intimacy with him, I know you won't make the same mistake I did... but I think disclosing AFTER is much harder than BEFORE so let me tell you how I got myself to finally pick-up the phone and tell him... 1. I watched a lot of youtube videos about how it's the right thing to do and HAVE to do. 2.I googled about other people in my situation and how to disclose. 3.I texted him telling him that I have something I needed to tell him, then I called after he said it was good to call, and I just Nike! (Do it/Did it) The common advice I found on every google suggestion and youtube video is to "STAY CALM", he will feed off of your emotion so be calm, and be informative without being too informative/overwhelming him. I only disclosed today, but I do know that the conversation went well for what it was and for being over the phone... What happens next I don't know, I cried after I got off the phone because I felt so awful. And though I think he knew I felt guilty, ashamed and whole bunch of other things, I didn't let it take-over the discussion of what's important which is letting him know that HE will be okay, and that HSV2 is okay, common, and treatable although incurable, also the statistics of the likeliness to spread.  There has been MANY cases where one person DOESN'T spread it to their partner long as they both take precautions. I know I messed up, so I'm not the best person to get advice from, but I hope this helps at least a little bit.  If you need any youtube video references, let me know.
    • Hockeyawesome1
      I’m going to be working outside in Florida and want to know how to stop cold sores in the sun 
×

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.