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    • Voyager2
      Sure hope this pans out. 
    • Voyager2
      Don't forget there are two promising vaccines on the prophylactic front (but only pre-clinical): The Trivalent vaccine worked well on guinea pigs:  https://pubmed.ncbi.nlm.nih.gov/32347775/ The Einstein (Xvax) vaccine also has a ways to go: https://x-vax.com/ The fact HSV529 is in yet another clinical trial is good news for herpsters. 
    • Davrk8
      thank you for the info. I am uncircumcised. I applied some clotrimazole cream during the last outbreak I noticed, which seem to do the trick (around a month ago). But now, there new dots are appearing at a different location on the glans. Wasnt sure if balanitis can come back so soon or if it could be something else. 
    • Josse
      Looks like mild balanitis. If you are uncircumcised then thats normal every now and then due to accumulation of yeast and the irritation of the foreskin
    • MikeHerp
      I think the simple reason is that this is a fund raiser that was started by our community rather than by Fred Hutch.  Or rather, FHC started it in response to our request.   I still think they should somehow feature it in their pages.  But anyway, that's just how they do it. Keep in mind that FHC's main focus is curing cancer.  It's a cancer research institute.  They might feel that putting stuff on their website that isn't directly related to cancer might give people the impression, especially cancer cure donors (who are by far the main donors to FHC), that FHC is losing its focus. So we have to work within these limits.   However, I do draw strength from the fact that FHC has tried to help us with the fund raiser.  Among others: 1.  When the new research paper is released, FHC has gotten an agreement with a prominent sexual health blogger, to promote the research and the fund raiser. 2.  There is another potential promotion in the works that might get back on track if the US is able to get the coronavirus under control. So FHC has actively helped us to promote the fund raiser.
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dormant_forever

Rough Sex and Outbreaks

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dormant_forever

I've read that rough sex causes outbreaks in some people but I never really understood why and why this would be possible. 

My suspicions of this being false comes from the generally stated belief that the virus lives in the nerve ganglion and not in the nerve endings or anywhere close to the skin. Furthermore, I'm uncertain how possible it would be, during sex, to aggravate an HSV infected cell nerve ending that would cause the ganglion to dispatch the HSV virus down to the nerve that would cause an outbreak.

My belief on the matter is after the primary infection, the original infection site becomes more susceptible to abrasions, tears, and infection due to the scar tissue at the site of infection caused by the 'trauma' of the original infection.

Therefore, I believe that during rough sex the existing HSV outbreak scar tissue, which is inferior to normal skin, is easily bruised and tears which would be followed by inflammation and skin repair which can be mistaken for an outbreak.

Any thoughts on the science behind this? 

Edited by dormant_forever

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Lakisha
On 8/11/2018 at 4:14 PM, dormant_forever said:

I've read that rough sex causes outbreaks in some people but I never really understood why and why this would be possible. 

My suspicions of this being false comes from the generally stated belief that the virus lives in the nerve ganglion and not in the nerve endings or anywhere close to the skin. Furthermore, I'm uncertain how possible it would be, during sex, to aggravate an HSV infected cell nerve ending that would cause the ganglion to dispatch the HSV virus down to the nerve that would cause an outbreak.

My belief on the matter is after the primary infection, the original infection site becomes more susceptible to abrasions, tears, and infection due to the scar tissue at the site of infection caused by the 'trauma' of the original infection.

Therefore, I believe that during rough sex the existing HSV outbreak scar tissue, which is inferior to normal skin, is easily bruised and tears which would be followed by inflammation and skin repair which can be mistaken for an outbreak.

Any thoughts on the science behind this? 

That's very interesting

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hopeing

Many people shed asymptomatically.

 

Quote

In persons with asymptomatic HSV-2 infections, genital HSV shedding occurs on 10.2% of days, compared to 20.1% of days among those with symptomatic infections. 8

If you are shedding asymptomatically then there is an active outbreak going on in the nerves and skin tissue, even if you can't see it.

This can be 10% the time, so that is around 36 days a year, which might coincide with some 'rough sex'.

My skin is also no longer the same, I don't know if its active virus or scar tissue is the issue.

I have perfectly fine scar tissue that is resistant to stress from other injuries elsewhere on my body. So this idea does not seem entirely correct to me, but I have only this anecdotal evidence.

Some spider venom's can cause old scars to reappear as wounds, indicating that either the wounds never totally heal or the different skin structures that form are susceptible to some form of chemical reaction.

Edited by hopeing

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