Jump to content
World's Largest Herpes Support Group
Sign in to follow this  
Cpt. Hindsight

In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency

Recommended Posts

Cpt. Hindsight

Pretty cool article discussing a study done in Vivo with rabbits targeting latent HSV1 and using what looks to be a different approach than CRISPR to prevent latent reactivation. I’m not a scientist, but the percentages quoted here sound pretty promising.

 

https://jvi.asm.org/content/92/16/e00812-18.full

 

 

Share this post


Link to post
Share on other sites
Freefalling87

What are the percentages quoted? I am not able to view the full document. 

Share this post


Link to post
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Sign in to follow this  

  • Similar Content

    • Learningtolivewithhsv
      By Learningtolivewithhsv
      So I made it to month four without a visible sign of an outbreak. I had a really bad outbreak in the ending of April and was diagnosed with GHSV1. My initial outbreak took about a month to heal and left scars (a lighter pigmentation from my overall complexion on my genitals). Sadly I have been ridiculously paranoid to the point I have taken two 7 day treatments of Valtrex. More than likely it was probably just yeast infections (I get them way more than I should, even before getting hsv). I also take lysine twice a day and three times a day when I feel like an outbreak is coming on. I’ve been applying tea tree to my genitals everyday since getting diagnosed to dry out any potential outbreaks that are present that I possibly mistake for an ingrown hair. When does the worrying stop? How often have anyone on this forum with GHSV1 get outbreaks? What’s are some good tips and tricks?
    • Ellabux99
      By Ellabux99
      23year old Female; Been a year since a swab came back HVS1 positive on my vag!
      I’ve never had an STI in my life and Really compared to my friends have only had sex a handful of times.. so why me. *Tear sliding down my face. 
      6 partners.. 2 of which were after my first outbreak (unprotected one nighters - clearly didn’t learn my lesson) 
      I didn’t tell them, is that bad of me? They didn’t ask.. and after all it’s just a cold sore nore was I having a flare up at the time I actually forgot I had it for a while!
      I have endlessly trolled website after website..most of them contradicting others, I feel like I know more now then any doctor ever could! 
      On my year anversery of contracting this thing I had a nasty flare up. 5 weeks. To be fair though no where near as painful as my first! Had I of not left it four weeks to get the antivirals I feel like it wouldn’t have been half as bad - this makes me feel a little better knowing it’s not going to be as bad as my first although I do here you can get them in you wee hole *ekkkkkkk
      that scares me.
      Anyways.. I want to know anything and everything about your experiences! 
      Triggers - food, sex, exhaustion, periods (or periods/ hormones effect HSV 2 more so)??
      I just started a very physical job when I got my first and current reoccurance riding race horses in the saddle for 5 hours+  6 days a weeks do you think irritation had somthing to do with it? I wasn’t sleeping well either so maybe I was exhausted? 
      Reoccurance rate 
      Do you tell your boyfriends
      Do you pretend your one of those people who don’t know untill they get a flare up - has that ever worked against you? 
      Do you just say you get cold sores? 
      If both has ghsv 1 can we have sex or will it still spread? 
      I went to a sexual health clinic after the outbreak upset and crying.. I asked if my sex life was over she basically laughed in my face and went don’t be stupid, I wouldn’t even tell them you have it! The question is what if I was to have a flare up.. and with this new job I worried flare ups are going to happen quite often! 
      After all it is just a cold sore. 
      Thanks
    • TCBH
      By TCBH
      Hey all,
      Found this on GEN-03, the vaccine that couldn't fund the final trials.  https://www.ncbi.nlm.nih.gov/pubmed/31103365?dopt=Abstract  Seems like they are trying to find investors possibly.  Does anyone have insight on this?  I would love to have a series of vaccine shots versus a daily antiviral pill.
       
    • hk81
      By hk81
      Hi
      I need advices from people who have experience with ocular herpes.
      3 years ago I had a few meetings with an asshole liar that denied to have any disease.
      Despite my being careful, I could not avoid to get infected because of his careless attitude.
      2 days after one meeting I developed a small peripheral corneal ulcer in my left eye; my doctor didn't relate it to sexual diseases and after a few days of wrong treatment (she told me to put gentamicin cream in the eye!!), it went away. I believe that I may have touched my eyes carelessly, as it was late and it was my normal behavior from getting tired.
      After another meeting with the guy (about 1 month later), I developed blisters in my genital area. It was a large outbreak, like a primary one. I couldn't see the area well, but I think there were more blisters one near the other, very painful. They caused a large single ulcer which took 3 weeks to heal. I went to a STD ambulatory but the doctor, by looking at it (the healing ulcer), said that it didn't look like herpes. I asked for swabs. To my bad surprise, she did not even make an herpes test and she told me later that it was not tested in her hospital (!!). I have never had such a painful and long outbreak again later, but only very short and mild ones.
      2 months later the blister in the eye came back. I went to an optic and he prescribed me antibacterial drops and steroids.
      About one year later I had a diagnosis of HSV1 in the urethra, which increased my suspects that that person had HSV. He still denied everything and when I asked him to get tested, he blocked all my contacts (I'm still considering how to report such a person).
      For almost 2 years my eye didn't have any problem, even if I went into a lot of stress (relocation, new job, a person toying with my feelings and poor sleep periods with anxiety, lots of exposure to sun, ...).
      I also had several vaccinations (HPV, Hepatitis, Tetanus), which I have recently finished (and they make me wonder if they made any good to my immune system).

      At the beginning of this year the problems with my eye started again.
      The first time I had small blisters in both eyes. In my left eye it's almost always in the same place. My right eye was never affected before.
      The second time I had again blisters in the left eye, this time after not much sleep and a day on the snow. Then in the right eye.
      I started visiting an ambulance for eye problems; every time I had a bad case of red eye, I went back to show it. In total I have been looked by 7 people, both when I had blisters and when I only had a bad red eye.
      Some of them stained my eye with pigments and watched through the lenses. Every time they told me it was not looking like herpes; probably they expected to see the typical branching lesion caused by herpes.
      Some of them said it was bacteria growing on my eye lids, some said I had dry eyes and my oil glands were obstructed. So most of the time I had indications to treat it with artificial tears or antibacterial drops and steroids (lotemax, prednisolone). One doctor once gave me acyclovir eye gel, not being sure if it really was herpes (after my indication).
      During the last visit (red eye only with no visible blisters, after a week end in the sun), I asked if I could get a swab. So they took it and they tested both chlamydia and Herpes. Both were negative.
      Despite their recommendation to use steroids, I applied also the acyclovir gel. I was surprised by the prescription of steroids without having properly tested for herpes. It is known that steroids reduce the immune response, that causes a proliferation of the virus and could make the infection worst.
      I applied the gel only to the affected eye. The redness would decrease significantly after 1 day and after 3 days it was almost looking normal. 1 week later after the start of the redness, the symptom appeared in the untreated eye. So I started to treat that eye in the same way. Then back again to the previous eye. And this continued from the beginning of the year until now (7 months).
      The redness is often accompanied with pain in the same side of my head. Often it happened after sun exposure (in summer period), biking for long, swimming training. Sometimes the affected eye has a small morning discharge near the lacrimal gland (yellow). Sometimes when I put artificial drops, I get some white patches on my eye lids, like if the tears are bringing out of my eye dead/dried skin.
      Many of these things are still making me suspect of herpes.
      So I would need some suggestions from people that have had the same problem. Can you relate to my symptoms? How did you get diagnosed? Is a swab a reliable test, or does it have many false negative? Did you get so many recurrences of red eye? And what did you do to stop them?
      I'm really depressed for what is happening to me and all the limitations that this is imposing me to my life. And also by the fact that I can't seem to get a proper diagnosis and treatment.
      Thank you for your help.
      L.
    • Rockstarnelly
      By Rockstarnelly
      Hi!
       
      I just want to say how happy I was to discover this site! Being diagnosed can feel so lonely and absolutely NO ONE can even begin to imagine how painful this is. I just want to share the story of how I got diagnosed about 5 months ago and I’ve have three outbreaks since. I am not 100% sure how I got it because I had only been with my current boyfriend who was a virgin before me. I had an outbreak 5 months into our relationship and it was such a hard time because it was right when a very popular tv show I was on started the season.  I was secretly having the worst time while all my friends and family thought I must be so happy to be on TV for this series. 
       
      Prior to dating my current boyfriend, the last time I had sex was a year and 2 months before the outbreak. The doctors always assured me it was extremely unlikely I got it from that partner so I was left in a place of confusion. I have oral herpes on my vagina and no one knows who it’s from.. and also my boyfriend got testing and was negative. I stopped questioning where I got it from cause it wouldn’t make the physical pain any less. Now I live in fear of infecting my boyfriend and I would never wish an outbreak on my worst enemy. It would hurt me so bad to give it to him. 
       
      After the initial diagnosis, it took me a little more than a month to completely heal. 
       
      I’m currently going through a back to back outbreak. I JUST healed from one that was lower on my vagina and now I’m experience one where I’ve never had it before. It’s on the front of my vagina, right about my lips and the outbreak dominates a wide area. This is a very uncomfortable place to have an outbreak because it’s always rubbing against something .
       
      If anyone has gotten this far in this post, I’m asking if there are ANY solutions for the pain. There isn’t much knowledge that’s easily accessible on herpes on the internet and I’m sure it’s because of the stigma behind this virus, but it can happen to anyone and is surprisingly very common. I can never find actually useful information for the pain, but I will admit that when I had my first outbreak, smoking weed helped a lot. It stopped and/or lessened the pain significantly while I was high, but I don’t want to have to get high to numb the pain. I like natural remedies as well, I don’t like taking Advil’s unless I absolutely have to and I don’t take it for this cause it didn’t work for me in the past.  If anyone else has GHSV1, (I’m assuming that stands for genital HSV1 cause this site is the first time I’ve seen that) please send natural remedies that have worked in the past for you. Anything that helps with GHSV2 would help too so feel free to share too, I’m just assuming something that helps the same exact virus as me might work best. Even if no one responds, it sure as hell feels good to just write me story and feel like I belong to a group of people who suffer the same thing as me. Forums like this should be recommended at the doctor cause no one ever talks about the depression that comes with this virus. 
       
      Peace and love y’all! I hope anyone else reading with a current outbreak starts to feel better soon. This shit sucks but we in this together!
  • Trending Now



×
×
  • Create New...

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.