Jump to content
World's Largest Herpes Support Group
Sign in to follow this  
Cpt. Hindsight

In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency

Recommended Posts

Cpt. Hindsight

Pretty cool article discussing a study done in Vivo with rabbits targeting latent HSV1 and using what looks to be a different approach than CRISPR to prevent latent reactivation. I’m not a scientist, but the percentages quoted here sound pretty promising.

 

https://jvi.asm.org/content/92/16/e00812-18.full

 

 

Share this post


Link to post
Share on other sites
Freefalling87

What are the percentages quoted? I am not able to view the full document. 

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now
Sign in to follow this  

  • Similar Content

    • information seeker
      By information seeker
      Hello, fellow reader I am in the process of having the government of Canada start a experimental treatment to cure herpes. I have been following alot of the research sexual transmitted illiness, and have noticed good results for gene therapy. I reason to believe that herpes can be cured within the next 2 years. With an experimental gene treatment. With recent cure of cells with HIV using crispr cas9. I believe a cured can achieve using a cocktail of drugs and gene therapy.  The process works by forcing the virus to awaken, while pumping antiviral to stop the spread of the virus. This would allow crispr cas9 to more easily to shred the herpe's DNA in the cell. This would also be combined with a TRIM5α Proteins to prevent the spread replication of the virus. Alot of this optimism comes from the gene therapy treatment that show results with current gene therapy treatments that appears to be successful. I am currently looking for people who live in Canada and are citizens or permanent resident. To join me in the process. If this is successful after a 12 month to 24 months treatment, a subject may be cured of virus permanently. This could also pave the way for future cure in other viral infection like herpes.
       
      Requirements 
      Living in Canada 
      Covered by national healthcare plan.
      Willing to be part of experimental treatment.
       
      Any one who does not meet these requirements can comment but may not be able to assist with the process.
       
    • sub16610
      By sub16610
      I'm really desperated, I've been visiting three different doctors and they didn't help me at all. Here is my story.
      I'm a 30 years old male in good physical and medical condition. Healthy and sporty lifestyle.
      - April 2018 : One-month holiday trip, including a lot of protected and unprotected sex with stranger girls.
      - May 2018 : Back home. I'm noticing redness on the glans and the foreskin of my penis, a few spots under the corona, and my glans looking wrinkled, very dry, and the foreskin looking like "sticky" when retracting the foreskin. I've been thinking about a fungal balanitis, so I've been applying Econazole, without any amelioration. Decided to get tested for HIV, IST, and HSV 1/2. Everything came negative, except HSV1 IgG Positive (IgM 0.70) - so pretty much an old infection. Showed my glans to Generalist Practician who said it looks normal, advises to avoid any chemical, soap, or whatever. I feel pretty much tired all the time, coffee won't help - but I don't feel pain. Tiredness could be related to pollen allergy - I've been tested with a very high IgE.
      - June 2018 : Things didn't improve. Exactly the same. Very intense redness after sex, that last up to a week. Decided to go to a dermatologist - even if I showed photos where the redness and the spots are really noticeable, she says she doesn't know, but it doesn't look like herpes to her. She told me to do nothing, avoid chemical and treatments, things should come back in order as nothing has been diagnosed by blood test.
      - November 2018 : After another rash/redness episode, went to an urologist. He said my glans and foreskin look normal. The reaction of these 3 doctors to my problem is absolutely incredible. My penis looks completely sick, I told them it has never been like this, and they say it look normal - I don't understand anything. I tried Fusidic Acid cream (antibiotic) without success. Then, I tried antifugal cream again, no result. Foreskin still stick when retracting. I'm beggining thinking about a rare genital HSV1, which outbreaks could be caused by rough sex. Here are some pictures of how my penis was looking at that time.
       
      - December 2018 : Had another blood test. HSV1 still positive, HSV2 still negative, HSV1/2 IgM now in gray zone.
      - January 2019 : Since a few days I have the most impressive outbreak I've never had. My glans and foreskin are now covered with red spots. I still don't feel pain - at most a little itchy - but my eyes are blood shot/pink. I don't really feel tired. Yesterday I ran to the pharmacy to buy Valaciclovir - I'm taking 500mg in the morning, 500mg in the evening.
       
       
      It's been now 8 months I'm dealing with that, and I still don't know what I'm fighting against. As you can guess, it's very hard for me, psychologically. 
      I'm avoiding having sex and when I do, of course I use protection. Since this last outbreak that really looks terrible, I wouldn't even dare have sex. I'm ashamed, feeling guilty, and it seems like doctors won't help me. 
      My only hope is this forum.
      What is your opinion ? Do you think it looks like an HSV1 outbreak ? If not, what could it be ?
      Thanks in advance.
    • anom1990
      By anom1990
      Hi everyone.
      I’m still trying to process this but I am a gay male in my late 20’s that was recently diagnosed with HSV-2 in October 2018. I haven’t been sexually active since 2015 and have only engaged in sexual activity with four people in my life. I’m feeling a lot of emotions because of this; sad, angry, confused, violated, ect. Thoughts like who would’ve thought someone like little ole me, compared to all of the VERY promiscuous people in the world, would end up with Genital Herpes ESPECIALLY when I’ve been abstinent and just focusing on myself for years. That was a gunshot to my soul. It’s crazy that I’ve ALWAYS done regular STD testing, thinking I was negative for everything only to find out that Herpes was never included in my testing because I never knew you had to literally ask for that until this year. The CDC and medical industry is so fucked up and wrong for that. I’ve always used protection, except with my first boyfriend but that was back in 2009-2010 and a condom broke with a sexual encounter I had back in 2011 and I remember immediately putting a new one on him. Unfortunately, all of the men I’ve dealt with sexually are questionable. Half of me wants to know who gave this to me but the other half is like what’s the point. I only have access to contact three of them (I don’t know where the other guy is) but I haven’t spoken to two of them in years, one of them in a whole decade and it would be pretty awkward for me years later to write them a message about herpes. My first boyfriend and I are cordial but he’s still immature so it would be very awkward with him. Anyways, as I’ve been thinking and backtracking my life, I would think I caught this back in 2011 because I remember my anus itching so badly but I thought it was just my hair growing back because I do recall shaving before having sex so I guess that was my first outbreak. Other times I would just get a minor itch in and on my buttocks but I never would’ve thought herpes. I’ve never got outbreaks on my penile area. This is all still confusing and baffling to me. I’m still sad and feeling like my future love life was taken from me. I feel like part of my confidence was taken from me. I don’t even feel comfortable flirting and finding people attractive right now. I’m just releasing my thoughts about my situation but I do have questions. My results also came back saying I had extremely low Vitamin D deficiency; does HSV-2 have something to do with that? Is there a test I could take to tell me exactly when I contracted this virus? This question may be TMI but I masturbate and I notice that a lot of sperm doesn’t cum out sometimes, does HSV-2 have something to do with that?
    • Alwayssmile_
      By Alwayssmile_
      Hi 
      I'm losing more hair than usual and not on any suppressive meds. 
      Was wondering if anyone else experienced this hsv2 diagnosis or even hsv1 diagnoses 
      If so how did you solve the problem? 
      Thank you. 
    • Hellothisisjerry
      By Hellothisisjerry
      Hello. 
       
      I had a mildly risky encounter. The girl had a bf for 1 year so that's a good sign. After they broke up we slept together a few times. Always using a condom. But on aug 26 we did not use a condom for sex. A week later I was moving into a new house and I legit wore the same underwear for like a week and also didn't wear underwear and wore tight jeans. 
       
      About a month later I developed a rash. It was painless. Hardly itched. No blisters or ulcers. Like red rash and partially inflamed skin.  This rash all occurred under my foreskin. (I am uncircumcised). And then it went away a day or so after showering. But before it went away it was getting redder and redder. 
       
      Another month later a less severe rash returned in the same area. I got std tested and all came back negative. The doctor did not do a herpes test, because there was no ulcers. And he did not do a herpes blood test because I have oral herpes when younger so it would show positive. But he looked at my penis rash and said it's just irritation or something. And gave me some cordrison (or whatever 1%) cream. 
       
      This is is the third time that this rash has appeared in the span of 5ish months. It's never painful itchy or whatever. 
       
      Gove me me your thoughts please. 
       
       
      Symptoms experiences  
      smegma more more than usual. Sometimes dry skin peels off (very little)
      no itch, no burn, 
       
      http://imgur.com/a/GmeJxcp
  • Trending Now

  • The Hive is Thriving!

    • Total Topics
      69,333
    • Total Posts
      466,587
  • Posts

    • information seeker
      I will get it fixed. I getting some help from some former journalist to make ads
    • Friends
      My Neurologist prescribed me Escitalopram for the nerve pain. Really haven’t started taking it, I was hoping the nerve pain just stops. Some way some how he told me that I will never have an outbreak and I haven’t..Weird?  Anyway I’m married, for 15years. When I discovered I had HSV my wife got tested as we’ll found out she had it since college!! Didn’t know that the fever blisters she got in college was HSV...I trust that this is how I got it. But wouldn’t you know she has no symptoms at all other than she knows she has it. There maybe something to this that there is something else wrong here besides HSV.
    • oneday
      Dr David Knipe from Harvard I'm pretty sure
    • Lucy29
      It’s not our heads that cause the sores I think this wound be very stupid for doctors to say as you can clearly see a sore.. however I do think if you are focused on a sensation constantly you will zone in on this feeling and always notice it I suffer from anxiety anyway in general so I do think some of my sensations maybe anxiety related.. but no or course cuts/ blisters  cannot be  
    • blurneworder
      I've noticed a trend of people sharing stories about doctors telling them the tingling sensation is all in their head or caused by the patient themselves. My doctors did the same thing. I explained that I am not making myself confused and dizzy nor am I causing my skin to cut itself open on my penis and lips.
×

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.