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VladimirM

Topical Imiquimod for Herpes Simplex Virus 2 Infection can reduce the number of recurrences.

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VladimirM

"Treatment with topical 5% imiquimod cream was initiated. The patient applied imiquimod to the HSV2 lesions 3 times over the course of 1 week. Each application was left on for 8 hours and then washed off. After 1 week of therapy, the skin lesions improved, with reepithelialization of the erosions on the glans (Figure 2). The patient noted a decrease in pain 4 days after the initiation of therapy. The imiquimod therapy was discontinued after 1 week, and the patient had no recurrences after 1 month of follow-up. He noted no adverse effects from the applications of imiquimod". 

"Topical imiquimod offers yet another alternative for treatment of HSV infections, particularly in the setting of emerging resistance. The exact antiviral mechanism of imiquimod remains unknown. It has no direct antiviral effect in in vitro studies. It is thought that its effects are directly related to its alteration of the immune response, targeting both the innate and cell-mediated pathways". 

It sounds good to me ☺...... especially this part where they mentioned   "no recurrences". The best of all is that imiquimod can be bought in a pharmacy. It's not something experimental that can not be bought.

https://jamanetwork.com/journals/jamadermatology/fullarticle/478437

 

Edited by VladimirM

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VladimirM

This guy is in a pretty bad condition with CD4-200 cells per cubic millimeter of blood and imiquimod helped him. ☺

"A normal CD4 count is from 500 to 1,400 cells per cubic millimeter of blood. CD4 counts decrease over time in persons ......" .hettps://www.webmd.com/hiv-aids/cd4-count-what-does-it-mean

Edited by VladimirM

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Freefalling87

Hmmmmm, most outbreak occurances only last up to 1-week in most people and most may not experience another outbreak for several months afterwards. It sounds like they made it seem like the treatment did something, but it may be that the results were just the natural cycle of herpes that people experience (at least those who have recurrent outbreaks).

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VladimirM
5 hours ago, Freefalling87 said:

Hmmmmm, most outbreak occurances only last up to 1-week in most people and most may not experience another outbreak for several months afterwards. It sounds like they made it seem like the treatment did something, but it may be that the results were just the natural cycle of herpes that people experience (at least those who have recurrent outbreaks).

After 5 months of constant infection with genital HSV therapy with imiquimod resolved his OB within a week. It is possible that the it is the truth what you are saying....... but 5 months of constant infection and then the solution in 7 days....Come on man.

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StayingUpbeat
On 9/1/2018 at 7:07 AM, VladimirM said:

"Treatment with topical 5% imiquimod cream was initiated. The patient applied imiquimod to the HSV2 lesions 3 times over the course of 1 week. Each application was left on for 8 hours and then washed off. After 1 week of therapy, the skin lesions improved, with reepithelialization of the erosions on the glans (Figure 2). The patient noted a decrease in pain 4 days after the initiation of therapy. The imiquimod therapy was discontinued after 1 week, and the patient had no recurrences after 1 month of follow-up. He noted no adverse effects from the applications of imiquimod".

One-off case reports on this topic triggered interest in the dermatological community in the early 2000's (when the paper above was published). A couple clinical trials were performed by the makers of imiquimod as a result.  Unfortunately, when run as a placebo controlled trial in healthy patients, imiquimod was found not to make a meaningful difference in the number of recurrences: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC128805/

  • Imiquimod 5-Percent Cream Does Not Alter the Natural History of Recurrent Herpes Genitalis: a Phase II, Randomized, Double-Blind, Placebo-Controlled Study

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VladimirM
On 9/4/2018 at 2:36 AM, StayingUpbeat said:

One-off case reports on this topic triggered interest in the dermatological community in the early 2000's (when the paper above was published). A couple clinical trials were performed by the makers of imiquimod as a result.  Unfortunately, when run as a placebo controlled trial in healthy patients, imiquimod was found not to make a meaningful difference in the number of recurrences: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC128805/

  • Imiquimod 5-Percent Cream Does Not Alter the Natural History of Recurrent Herpes Genitalis: a Phase II, Randomized, Double-Blind, Placebo-Controlled Study
Quote

Antiviral and antitumor effects are seen with imiquimod cream through activation of the innate immunity and upregulation of cytokines, such as interferon-alpha, Dr. Vanderhooft said. It’s FDA approved for genital and perianal warts in patients older than 12 years of age, as well as for actinic keratosis, superficial basal cell carcinoma, and antiviral-resistant HSV in patients older than 12 years of age.

 

This is probably a mistake. What do you think?

https://www.mdedge.com/pediatrics/article/102139/infectious-diseases/expert-shares-treatment-tips-molluscum-contagiosum-and

 

Edited by VladimirM

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Morpheo

They use this to treat skin canccer, and to treat hpv. It basically boost your inmune system on a "local" lvl, wich explains why it worked for this guy. For a person with normal inmunity it would be a fucking insane thing to use this for hsv because its really really agressive on the skinn. You would probably get more benefits by treating your ob with aloe vera.

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VladimirM
6 hours ago, Morpheo said:

They use this to treat skin canccer, and to treat hpv. It basically boost your inmune system on a "local" lvl, wich explains why it worked for this guy. For a person with normal inmunity it would be a fucking insane thing to use this for hsv because its really really agressive on the skinn. You would probably get more benefits by treating your ob with aloe vera.

It’s FDA approved for HSV!!

What is up with that??

Edited by VladimirM

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Morpheo
On 2/11/2019 at 2:15 AM, VladimirM said:

It’s FDA approved for HSV!!

What is up with that??

sure its approved for that but its really really agressive for the skinn. 

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GlitterDx

The side effects of Imiquimod are evil. It is best saved for dire skin ailments. Most people quit Imiquimod due to side effects. It causes aches and pains, thin skin conditions and severe itching and more... 

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jtx30
Posted (edited)

It works and if you can tolerate the skin issues it causes and it can and may cause a recurrence, but it will put off  the next recurrence anywhere from 3-6months.  There are lower amounts other than 5% which could reduce the side effects.  

Edited by jtx30

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BioHacker
Posted (edited)

Immiquimod and/or Resiquimod are not strong enough for HSV. Those types of topical treatments are best for local / superficial skin issues - like skin cancer, or warts. It's an alternative to a dermatologist freezing or lasering something off the skin. Even if it helped clear a specific HSV lesion, that's all it would be doing - studies have shown no reduction in recurrences in the long run. This suggests the immune system reaction is local and temporary (at the site of topical application). Some studies have also tried using Immiquimod topically at the site of a intradermal vaccine injection - to stimulate immune response to the vaccine (if I remember correctly, it didn't work too great, but it helped a little). For a patient to have significantly reduced HSV recurrences, they would most likely need a way to trigger the immune system to make lots of HSV-specific CD8+ T Cells. This is possible, of course, but most of the vaccine frameworks that do that are still only being used in cancer research - where people think that the severity of the illness justifies attempting it.

Edited by BioHacker

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MikeHerp
On 3/2/2019 at 8:56 PM, jtx30 said:

It works and if you can tolerate the skin issues it causes and it can and may cause a recurrence, but it will put off  the next recurrence anywhere from 3-6months.  There are lower amounts other than 5% which could reduce the side effects.  

This phase 2 study mentioned above, confirmed that it doesn't work for HSV.   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC128805/

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