Jump to content
World's Largest Herpes Support Group
Quest

CRISPR to halt the progress of Duchenne muscular dystrophy (DMD) in dogs. Potentially in humans, too

Recommended Posts

Quest

 

https://www.digitaltrends.com/cool-tech/crispr-gene-editing-dmd/amp/

Quote

CRISPR gene editing can be used for all manner of applications, from creating more efficient crops or heat-resistant cattle to coding GIFS into DNA. Now, scientists from the University of Texas Southwestern have showcased another potentially transformative use case for the technology: Using CRISPR to halt the progress of Duchenne muscular dystrophy (DMD) in dogs. One day, it could potentially do the same in humans, too.

 

DMD is the most common fatal genetic disease in children. The result of a mutation that limits the production of muscle-function protein dystrophin...Children who suffer with DMD often die as a result of their hearts lacking enough strength to pump, or their diaphragm being too weak to breathe...

In their demonstration, the UT Southwestern scientists were able to use a single-cut gene-editing technique to restore the dystrophin in muscle and heart tissue by a massive 92 percent. According to experts, a 15 percent threshold could be enough to significantly help patients.

Previously, the researchers showed that it was possible to correct DMD mutations in both mice and human cells. However, in this latest breakthrough, they demonstrated that it is possible to employ this strategy in dogs, by far the largest mammals this has been applied to. Four dogs were involved in the study, all of which shared the same genetic mutation seen in DMD patients. The CRISPR gene-editing components were delivered through a harmless virus, after which it proceeded to carry out the successful gene-editing work.

 

Share this post


Link to post
Share on other sites
Nietzsche

Great to see progress in CRISPR research is there any link to HSV

Share this post


Link to post
Share on other sites
dont quit!17
5 hours ago, Quest said:

I love anything positive! I need it succeed in any way! I want it to be around for us!

Here's Why CRISPR Stocks Rose as Much as 18.7% in August

https://www.fool.com/amp/investing/2018/09/04/heres-why-crispr-stocks-rose-as-much-as-187-in-aug.aspx

Thats good news. I've had young patients with Muscular Dystrophy and it is very debilitating genetic disease. They would probably trade places with most us here on this forum in a heartbeat. Good share. 

(some perspective to start my day)

Share this post


Link to post
Share on other sites
Quest
8 hours ago, dont quit!17 said:

Thats good news. I've had young patients with Muscular Dystrophy and it is very debilitating genetic disease. They would probably trade places with most us here on this forum in a heartbeat. Good share. 

(some perspective to start my day)

It sure does put it in perspective! I am not sure I would have worked on my health as much if I didn't know that I had a failing immune system! I really don't get colds so I would have thought my immune system was okay. I hope your patients get to benefit from it one day!

Edited by Quest

Share this post


Link to post
Share on other sites
Voyager2

Good find. This thing works. They used CRISPR to reduce muscular dystrophy by 92% in 4 dogs.

Excision Bio says their own CRISPR/HSV program will be in the clinic by 2021 (a phase 1 trial is 3 years away). Let's hope things move quickly at that point due to the increasingly widespread use of CRISPR around the world and lessons learned.       

Share this post


Link to post
Share on other sites
Quest

Everybody can learn from each other! I hope they do share their information not like those other scientists!

Share this post


Link to post
Share on other sites
Voyager2

Very good news! We've heard about unintended off-target cuts for awhile and wondered if it would delay the use of CRISPR. This article describes a logical way around the problem and with any luck it might not be an issue when Excision Bio starts HSV human trials in 3 years. Maybe they'll start sooner if they can routinely cure monkeys? 

Share this post


Link to post
Share on other sites
infoguy123

Ya it's awesome news. I can't wait hear that they've(functionally/therapeutically) cured 20 people in a trial 3 years from now. It will be almost as good as the actual cure because we'll know that it's just around the corner

Share this post


Link to post
Share on other sites
dont quit!17
8 hours ago, Voyager2 said:

Very good news! We've heard about unintended off-target cuts for awhile and wondered if it would delay the use of CRISPR. This article describes a logical way around the problem and with any luck it might not be an issue when Excision Bio starts HSV human trials in 3 years. Maybe they'll start sooner if they can routinely cure monkeys? 

You think Excision would pay attention to studies like these?

Share this post


Link to post
Share on other sites
35hope
18 hours ago, infoguy123 said:

Ya it's awesome news. I can't wait hear that they've(functionally/therapeutically) cured 20 people in a trial 3 years from now. It will be almost as good as the actual cure because we'll know that it's just around the corner

i know i wish some people from the companies would just bootleg the vaccines if they had some insider info on it being successful 

Share this post


Link to post
Share on other sites
Voyager2
On 9/15/2018 at 8:54 AM, dont quit!17 said:

You think Excision would pay attention to studies like these?

Excision needs to get around the off-targeting problem and are likely keeping an eye on possible solutions in the literature.

  

Share this post


Link to post
Share on other sites
Divon
12 minutes ago, Onehotmess said:

Thats an article from an investors perspective, stock market to be exact. I would say that it is unlikely that researchers will not find any real use of CRISPR because it is so hyped to investigate possibilities with it atm.. However, people who invest hard on it do so with the hope that this will be the big thing in medicine that will cure everyone from everything and make old people young again. 

I have been saying again and again on this forum that you can´t put all your hope on CRISPR. There are a lot of other things to have hope for in the herpes treatment. CRISPR is obviously more exciting though because it might have a chance to kill the latent virus one day, however that day is quite far away by looks of it. 

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now

Advertisement

Try a Lysine supplement for cold sores

  • The Hive is Thriving!

    • Total Topics
      68,277
    • Total Posts
      455,762
  • Posts

    • Quest
      Him holding my hips, grabbing ass, then grabbing his cock is what I worry about. I also worry about shedding anywhere from the boxer shorts area and that's a mighty big area. It is the unknown. It would be nice to cover the entire area and then I just don't have to worry! Then the part that is exposed which  would be a very small spot. Maybe cover with that liquid glove?!? I just like the idea of doing my best
    • 35hope
    • Hairpees
      I wouldn’t because that would be outing myself as well unfortunately. It just sucks because our mutual friends have no clue why I carry such resentment towards him, and wonder why they can’t even bring up his name around me anymore. Im sure they think I’m a crazy jealous person who is hurt things didn’t work out or that I’m being dramatic for no reason. I can’t explain to or confide in anyone but the users on this forum.
    • Jorjanewnew
      Girl! I am actually on the same exact position. My new bf gave it to me and he put the blame on me! When he was my 2nd partner and I hadn’t had sex in 5 years (last guy was a virgin). I know that alone feeling but know you’re not alone. I just got diagnosed 2 weeks ago too. It’s crazy you see yourself differently but I promise no one around you does.
    • Cas9
      How would that location (upper crack) come in contact with him during doggy style sex? Maybe after the act if he fell on top of you while you're face down. I would suggest simply observing whether there are sores in these areas that are somewhat removed from the genital area. If there are no sores than the odds of you transferring to him such as the lower stomach or leg etc.., are pretty damn low. Obviously, we can come always come up with a scenario where you could transmit. For example, if you were on your stomach and he was sliding his dick up and down your butt crack and you had sores there, then yes, he could get infected. If you were just shedding there it would be less likely but possible. But try doing that with your clothes on. I don't think that would work out very well; Do you?  Wearing clothes during sex like that woman you portrayed in your earlier comment is sexy. But that's all together different.
×

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.