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    • Cas9
      @Ohsotired It took 10 years for mouse studies? Not sure if that's true, but anyway, it takes a while when starting out because you're kind of starting from scratch. That also involves in vitro work. Then you need to go to mice. So the in vitro and mice work is where a lot of the figuring out has taken place. It involved a lot of painstaking work. In fact Dr. Jerome started with an old style editor (CRISPR hadn't been invented yet). When he wasn't getting the results with whatever editor he was using, and CRISPR was invented, he then switched to CRISPR. He got worse results with that. His team then figured out what the issues were, step by step. And finally we are where we are; i.e. 90% and 50% cleavage in SCG and TG. And he knows what the issue is regarding improving those percentages to 90%+ in the DRG and TG. So a lot of the figuring out took a while and now we just need to see that it works in guinea pigs and then primates. Unless something goes wrong, and there's no reason to believe that it will, we are not going to take 10 years for each animal of course. If things go smoothly I would say 3 or 4 years. Then on to clinical. But we'll see. " Most researchers spend 3-6 years in the preclinical stage of research, 3-7 years in the clinical phase, and 2-5 years afterwards to launch the drug for public use. That’s Titans about 18 years in all for a drug to make it to mainstream. " So you chose the high end for each range. If I choose the low end for each it's 8 years. It's really impossible to predict. But I think the majority of us think that if it's successful it's at least 10 years away. Before your research, how long did you think the process would take? If it takes 10 years, how old will you be?
    • hk81
      The funding from NIH for the lab tests on mice will end in 2023, so this can give an idea on the timeline. https://grantome.com/grant/NIH/R01-AI132599-01A1 When the tests are moved to bigger animals (guinea pig and monkey), the possibility of experimentation is lower due to higher costs. The tests on monkeys are done only when the research has reached some solid results and only a few combinations are tested (see for example the tests done by ExcisionBio on monkeys for their CRISPR therapy for HIV). So I don't expect that (if everything works as expected) there will be bigger delays at that point. Usually when the funding from NIH ends, the research should have managed to run extensive tests on animals to gather further funding (often private) to move toward clinical trials. This period is called "the valley of death"; if there is not enough evidence that the therapy is effective, it will be more difficult to gather the attention of private investors and the research will run on lower funds and it will slow down or it will be stopped. Also: since it is a therapeutic application, the clinical trials might be faster than a prophylactic vaccine, unless side effects arise. There is no need to check that the therapy is protective on the long time, waiting for the participants to expose themselves to a pathogen (I also would not expect that they will check the condition of a participant for too long, because he might have exposed himself to another strain of herpes or the same one, if immunity will decrease after the therapy).  Hopefully once the first successful clinical trial, they will be able to get a fast-track and early-access as it happened with pritelivir.
    • asdfz
      Any CRISPR updates for HSV?
    • Ohsotired
      I don’t know why, but I decided to research the drug/medicine implementation process this morning. In my quest of knowledge, I found some disheartening information. Most researchers spend 3-6 years in the preclinical stage of research, 3-7 years in the clinical phase, and 2-5 years afterwards to launch the drug for public use. That’s Titans about 18 years in all for a drug to make it to mainstream.  Dr. Jerome has been working for nearly 10 years & has not finished the preliminary preclinical data. He’s only completed work with mice: no guinea pigs or monkeys. The reality set in that there’s so much more time needed. Hopefully, he doesn’t take nearly 10 more years to complete the next studies.    Afterwards, he’ll need to conduct a Phase I trial on humans, followed by a Phase IIa trial, proof of concept trial, Phase IIb trial,   Phase III trial, & regulatory review.  I was cautiously optimistic, but I’m starting to become cynical. This could take upwards to 20 years.   
    • Just a human being
      Try google T cells gut flora encephalitis. Can try to find it if u can’t.  I know Wilso could crack it but it common knowledge and educated on in groups by well respected HSV advocates from organisations that the virus can travel via other nerve routes. Whether this has any baring or truth in your case at all no idea. 
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Kcrazy1214

36 weeks pregnant and confused

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Kcrazy1214

All this from what the doctor told me and look up in my medical fill. So back in 2013 I went to the ER for lesion on my vaginal area. The ER just gave me medicine without the results. I than later a few weeks later went to my clinic. The doctor there took a culture of lesion (on vaginal) it came back postive for hsv 1 and negative for hsv 2. The doctor prescribed antiviral pills. So I go to the doctor again in 2016 for lesion again this time another doctor at my clinic does the culture (on vaginal). It comes back positive for hsv 1 and negative for hsv 2. In 2017 I go back to my clinic to have a well women. They took my blood for hsv 1 and hsv 2. Both came back not detected. Now I'm 2018 in one of the doctors at my clinic says I have hsv 2. I'm currently 36 weeks pregnant and freaking out. They want me to take antiviral. Here we're I'm confused the doctor was not sure because she was reading other people notes left in my chart. She also said it can't be hsv 1 because it was on my gential area. That the blood test I had done could gave a false negative result. In the only way for sure I would if I have it is if I had a outbreak and came back for her to test it. I want know has anyone else experience this? In should the herpes antibodies be in my blood if I had since 2013 or 2016? Please help me

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ExhaustedGirl1

Sorry for the confusion you must be dealing with here. This is what I believe is happening.

I think you have genital hsv 1 and that your blood test was a false negative (perhaps because quite a bit of time has passed since you were infected likely in 2013 and the antibodies have since dropped, or because the IGG test misses 30% of HSV1 cases, or both reasons). I think it's safe to say that you do not have hsv 2. Your doctor in 2018 is misinformed, just because someone has genital HSV doesn't mean it's automatically type 2. Type 1 can also present itself on the genitals and if you have had a positive swab for HSV1 that confirms it over a negative blood test.

What you could do is get a Western Blot for confirmation, as it is a more accurate blood test than the standard IGG and it would likely pick up the HSV1 but since you have had a positive culture, I would take that as the evidence you need.

You and your baby will be just fine. I don't know a lot about pregnancy and HSV, maybe someone else can speak to that but it may be a good idea to take antivirals just in case, although the risk is very low unless there is an active outbreak at the time of birth-- from my understanding. Also, you seem to have quite an established infection (seeing as this began in 2013) meaning that any risk is further reduced.

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