Full paper here: https://www.sciencedirect.com/science/article/pii/S0264410X18315652
Note sure if anyone wrote about this. I couldn't find any results for VC2 in the site's search. This is a live attenuated vaccine from Louisiana State University. The results do not seem super promising, as reducing shedding/recurrance by < 70% pre-clinical is common in many discontinued vaccines. Still, research is being done, which is always great!
"Our studies also showed that VC2 vaccine decreases the clinical severity of acute and recurrent HSV-2 disease in guinea pigs when provided by intramuscular vaccination. During the primary infection, animals vaccinated with VC2 had a significant decrease in clinical severity and replicating virus in the vaginal vault. Prophylactic vaccination also decreased the quantity of virus in the DRGs when compared to the No Treatment group. The ability to protect neural tissue from latent infection probably contributed to the decrease in the number of animals with recurrent lesions by 67% and the number of days with recurrent vaginal shedding by 46%. This reduction in shedding is particularly important because transmission of HSV-2 to uninfected persons is largely due to asymptomatic shedding , ."
"When tested as a therapeutic vaccine, i.e., one designed to decrease recurrent disease and recurrent virus shedding in those already infected with HSV, the VC2 vaccine was not effective although it did reduce recurrent shedding, at least when compared to the gD2 vaccine. This may be because live attenuated vaccines have only limited replication in hosts that are already infected and thus do not have much of an impact in improving the immune response. Because infected hosts have frequent reactivations of virus that would be similar to a live vaccine inoculation it may be difficult for the vaccine to improve the immune response unless it is able to induce responses not activated by the host’s recurrent virus replication."
So I have been getting pimples on my penis, 2 are chronic and do not move and react like a black head when squeezed, thin wormy thread of pus. Once in a while I will get a larger one midway up my shaft that can be more like a deep pimple under the skin that can pop. Happens about 3-4x a year. This does not hurt or crust over. The other day when cleaning my penis I noticed a rough patch under my forskin and found this small open wound. It alarmed me so I went to urgent care. After saying what I said above the practitioner said “that’s herpes” before seeing my penis. I later went to the VA urgent care for a second opinion and she said it’s not. I have been married 10 years with a break 3 years ago. Here are two angles of the same dot, do any of you have any thoughts on my experience? Syphilus test came back negative.
Has using valtrex daily help you stop the spread of herpes? I'm terrified I'll spread it to my new partner.
I just started getting upper and inner thigh pain and itching for the last week. It really hurts in the crease between my thighs. I am also having sharp stabbing pains that come and go all around my vagina and butt. My last possible exposure was in Sept and I was tested negative then but why am I having all these symptoms. I also saw a small white bump vaginally but it disappeared the next day so I couldn't have it swabbed. If anyone has any advice or share their symptoms