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Ribbon35

Better results with acyclovir than valtrex? HSV2

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Ribbon35

Since May I have been taking Valtrex. At first it was 500mg once a day then it increased to 1000mg once a day in June after frequent outbreaks persisted. I've had a total of 9 outbreaks since May and was diagnosed with hsv2 in March of this year.  The past three weeks I've had severe dizziness, especially when lying down and getting up in the mornings. Today my doctor suggested taking acyclovir 400mg twice a day. Has anyone switched from acyclovir to valtrex and experienced better results/less breakouts?

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WilsoInAus

Valacyclovir is more ‘available’ to your body than acyclovir. Hence you cannot get worse results (for your herpes) taking Valtrex (which is valacyclovir) compared to those tablets with acyclovir.

Your doctor seems to be providing advice that acyclovir may lessen your broader issues compared to Valtrex. You will need to experiment to see if you feel it addresses your outbreak frequency to the same extent.

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valleynovascotia
1 hour ago, WilsoInAus said:

Valacyclovir is more ‘available’ to your body than acyclovir. Hence you cannot get worse results (for your herpes) taking Valtrex (which is valacyclovir) compared to those tablets with acyclovir.

Your doctor seems to be providing advice that acyclovir may lessen your broader issues compared to Valtrex. You will need to experiment to see if you feel it addresses your outbreak frequency to the same extent.

Does acyclovir reduce shedding as much as valtrex and what about famvir?

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WilsoInAus

Acyclovir and valacyclovir in the end do the same thing. Testing shows that provided acyclovir is taken as directed at the same times each day, it is the same effectiveness (or marginally less effective at worst) as valacyclovir in reducing shedding and outbreaks.

Valacyclovir is absorbed quicker and survives longer in the body. For this reason it is more forgiving as to when you take it. Its effectiveness is stronger with a more irregular pattern in the timing of taking the tablet compared to acyclovir tablets. This is the main reason why it is preferred.

Penicyclovir (Famvir) appears to be marginally less effective than valacyclovir.

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Ribbon35
1 hour ago, WilsoInAus said:

Acyclovir and valacyclovir in the end do the same thing. Testing shows that provided acyclovir is taken as directed at the same times each day, it is the same effectiveness (or marginally less effective at worst) as valacyclovir in reducing shedding and outbreaks.

Valacyclovir is absorbed quicker and survives longer in the body. For this reason it is more forgiving as to when you take it. Its effectiveness is stronger with a more irregular pattern in the timing of taking the tablet compared to acyclovir tablets. This is the main reason why it is preferred.

Penicyclovir (Famvir) appears to be marginally less effective than valacyclovir.

Well this is discouraging news since I'm having frequent outbreaks on Valacyclovir and dizziness. It's not sounding like acyclovir is known to be more effective in the frequencies of my outbreaks.

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WilsoInAus

No it’s not, nor is it less so if you take it regular in a time of day sense.

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Ribbon35
10 hours ago, WilsoInAus said:

No it’s not, nor is it less so if you take it regular in a time of day sense.

Not sure what you're saying. Can you word it differently?

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WilsoInAus

Acyclovir produces the same outcome as valacyclovir, but only if you take it precisely as directed at the same times every day.

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friendlyboy
On 9/12/2018 at 6:57 AM, Ribbon35 said:

Well this is discouraging news since I'm having frequent outbreaks on Valacyclovir and dizziness. It's not sounding like acyclovir is known to be more effective in the frequencies of my outbreaks.

Valacyclovir half life in blood plasma is just 3 h, that means after 12 h there is almost none of it left in your body. Also, the absortion efficiency decreases as you increase the dose, meaning a 1000 mg dose will be less efficient than 2 x 500 mg doses spread more than half an hour apart. The risk of side effects also increases with the dose.

I suggest you take your total 1000 mg daily dose as 500 mg each 12 h. There is no risk in doing so and your condition will probably improve.

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