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Celeste68

Antibody Level Readings? What does it mean?

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Celeste68

:(Does anyone know what you can tell from HSV antibody levels? Like, if you have a 4.4, what does that mean? Can we tell how long we've had it by the level amount? I think I may have contracted it a few years ago, but just now getting a positive test through blood work. I thought about it more and think that I had flu-like symptoms after a sexual encounter and went to get tested then. I'm thinking it was too soon to detect the antibodies, if the blood tests were even available then (think they weren't). I never got any bumps, etc...just some discharge and aching body. This was probably it. I'd really like to know how long I've had it and my levels seem high, 4.4 and 5.5.

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Celeste68

Thanks!

Thanks for your informative reply. I guess there's really no way of knowing how long you've had it by the levels. I'm pretty sure it's an old infection because I've been with my partner for almost 3 years, unless, of course, he's been unfaithful recently. Guess you never know so it's best not to point the blame at anyone. Thanks again.

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shockedgirl08

I have a question on this...

So if someone had no antibodies, or low antibodies, their bodies couldnt fight off the infection or an OB

As they develop the HSV antibodies. their body can then begin to fight it off..

How come people get OB's if they have the fighting antibodies to fight the infection?

What level of antibodies is good to have in order to fight off the OB's successfully?

for example, would a person with 6.2 body fight it and get less OB's than a person with 2.1? you understand what i mean?

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helied2me

I don't really have an answer to that shockedgirl, but I assume a higher level of antibodies might be more effective in fighting it as far as the severity of the outbreak. This is probably why, in time, outbreaks usually become less frequent. It would also have something to do with the amount of virus that replicates.

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shockedgirl08

Thanks, thats kinda what i thought, but thought i would throw the question ot there to see what people thought and say... I wonder what the highest level of antibodies a person can have...

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Mr_Smith

The numeric values mean nothing, it's just a number There's no difference between a 3.7 and a 6.2, they're both positive values. There's no correlation between numbers and frequency of outbreaks, likelihood of passing it on, or winning the Lottery. It's just a number.

You could draw blood into three different vials, send two of them to different labs, wait a month before sending the third vial to one of the same labs, and you'll get three different numeric values. They would all be in the same range for Negative or Positive. The reason is because the 'controlled sample' for which you blood is compared against would be different at each location, or a month later. This is why you can't compare and 'track' your results over time. They're just negative or positive.

Regards

Mr Smith

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lola1

Antibody levels don't give much info..

So does that mean that if you have "low" antibodies to HSV2...meaning, I had an IGG HSV2 test that was 1.61, which my doc was a "low positive".....and based on that the dr. said I was "recently" infected within the past 3-4 months. Versus if I had "high" antibody levels (for example, a 5.0 or above..), then she said that means that I would have had the infection for a long time and not recently acquired it..more time, so more antibodies in the blood..I guess?

At first, I believed her, but now I believe this is a crock. I have done some research and it seems that everybody is different in regard to antibody levels, as stated in the above post. Yes, it takes a certain amount of time to "seroconvert"..(go from negative to positive antibody reading)..but after that, it seems that you can not tell much else from the antibody level, like how long you were infected, how contagious you are, etc..what you can tell is basically if you are negative or positive...and that's it..

Proof of this theory would be my bf's reading for his HSV1...he's had oral cold sores all his life..and tested for HSV1 recently..and his level was a "low" positive IGG of 1.10..now, he's had cold sores all his life, but his antibodies are really low; but you'd figure he'd have high antibodies (5.0 or more..) as his body has fought it all his life..(according to my doc's theory..)

Bottom line, I really don't think the antibody levels tell anything other than NEGATIVE or POSITIVE...what does anybody else think?

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sasha08

Hi Lola1, My doctor told me that my antibody level was 1.06 or 1.6 (I was extremely distraught and she got a little tongue-tied explaining this part) and that she wanted me to come back to get retested in 2 months to see if my levels have gone up (would show if I had been recently infected) or down (possibly come back negative). My doc seems very well-informed. Everything she has explained to me about herpes has been accurate according to the research I have done online, so I trust what she says and have my 2nd test on April 15th. She said she did not think I would get a negative result but if the antibody levels went up it would show that I had recently been infected. So I will post when I get my results back and maybe that will help clarify this question for others.

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Mr_Smith

The general rule is to retest if your HSV2 result is below 3.5 and a preexisting case of HSV1. I'm no doctor, but I just recommend when it's below 3.5. Period.

Regards

Mr Smith

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shockedgirl08

if anything 1.0 and above is positive, why would anyone with a 3.5 or below test again, its positive if its 1.01 right

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Mr_Smith

No blood test for herpes is 100%, not even the Western Blot.

The HerpeSelect got FDA approval in 2000 or 2001. What was discovered after FDA approval was the error rate jump when there was a preexisting case of HSV1. The standard practice was to retest when your HSV2 value was below 3.5, which is referred to as a 'low positive', AND had a preexisting case of HSV1.

Over the course of time, it just became retest if had a low positive, kind of a confirmation test, or a second opinion.

In Sept of 2006, The HerpeSelect ELISA and Immunoblot tests were reformulated to correct this issue. The HerpeSelect accuracy is now closer to the Western Blot at about 98% for sensitivity and specificity. However, you'll still see experts (ie; T.Warren and H.Handsfield) recommend a retest.

But like I say, no test is 100%, but it's the best we have today. The FDA has approved the "biokit HSV-2 Rapid Assay" as a confirmation test. It's a easy and fast test, results while you wait, in about 20 minutes.

search out:

'low positive IGG Herpeselect'

'retesting herpeselect recommended'

Regards

Mr Smith

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