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Little Star

Vaccines

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Little Star

Sorry but I don’t really understand the different between the various vaccines that people talk about on the forum.  Could someone please explain to me in simple terms what vaccines are currently in testing or look promising to help the ones of us already infected with ghsv1. I’m not interested in hearing about preventative ones, ones that have failed or CRISPR. Many thanks. 

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WilsoInAus

@Little Star maybe I can put forward a gross generalisation and say that there are two types of approaches to addressing the issue of eliminating either the virus or its symptoms. These are:

1. Promoting a strong immune response to prevent infection in the first instance or enhancing the immune system against an existing infection. This will typically involve presenting a form of the actual virus, usually altered or synthetic, to illicit the immune response. The key issue I think you are referring to here is that people have an unrealistic expectation that these will help a person with an infection, when in 95-99% of the time, they are unlikely to do so as their immune systems are already optimal. Over time, I suspect that they might be able to design a vaccine that assists the bulk of people with the virus to reduce symptoms and shedding. However it is likely that the preventative form will commence reducing the incidence of HSV and hence the need to develop such a vaccine.

2. Disrupting the virus and its replication such that it in theory it is extinguished or otherwise locked in the nerve cells. This is a better way to go in terms of people who have the virus now. Although there are novel ideas, ideas are simply not matched to the pragmatics of available science. This gap will close over time and it will be a race to see whether a vaccination at birth for all newborns wins that race!

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MikeHerp
5 hours ago, Little Star said:

Sorry but I don’t really understand the different between the various vaccines that people talk about on the forum.  Could someone please explain to me in simple terms what vaccines are currently in testing or look promising to help the ones of us already infected with ghsv1. I’m not interested in hearing about preventative ones, ones that have failed or CRISPR. Many thanks. 

To keep it simple: All vaccine attempts have failed.  None are currently being further tested.  

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WilsoInAus
1 hour ago, MikeHerp said:

To keep it simple: All vaccine attempts have failed.  None are currently being further tested.  

That is not true in a preventative context; potentially from a therapeutic sense.

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fixme1
4 hours ago, MikeHerp said:

To keep it simple: All vaccine attempts have failed.  None are currently being further tested.  

Admedus are still going 

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Little Star

Thanks for the info guys. If Admedus makes it to market does anyone have any idea how effective it would be for ghsv1? I know both viruses are almost identical but it hasn’t been geared for type 1 has it? Thanks again for sharing your knowledge with me, I appreciate it. 

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MikeHerp

Do you have any link that suggests that Admedus is still ongoing?  

I think I recall some one sentence somewhere that suggested they might test it in China...  But not sure whether that's definitive.  also, there's not much about the vaccine on Admedus website.  

5 hours ago, WilsoInAus said:

That is not true in a preventative context; potentially from a therapeutic sense.

What preventative HSV vaccine is being tested?  

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Pokemon
10 hours ago, MikeHerp said:

What preventative HSV vaccine is being tested?  

The following are therapeutic and may or may not also be preventative:

1. Admedus is in Phase II

2. Dr. Halford's vaccine received investment form Peter Thiel in 2017 and that is reported to be in testing. Details are not available probably due to legal action by 2 or 3 Theravax trial participants.

Wikipedia has a useful status: https://en.wikipedia.org/wiki/Herpes_simplex_research#Vaccine_candidate

 

Edited by Pokemon
Clrification

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bigfella01

In relation to Admedus google "Star Bright Hong Kong hsv 2 vaccine" as there is some information there pertaining to the Admedus vaccine program going forward.

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MikeHerp

There's almost no trace of the HSV product that Admedus is supposedly developing on its website.  I recall there was some one sentence in some presentation that it might get tested some time in China, like in 2020 or 2021.  I don't think it is being tested anywhere at the moment.  Now I read your last link and yes, it looks like they got some money to try to move the HSV and HPV vaccines along.  But again, no new phase 2 trial has been announced.

Halford's vaccine isn't being tested in humans anywhere.  No idea whether it will get tested again.

The Taiwan company (UnitedBio) that might test their product, haven't started recruiting volunteers yet.

So, in summary, no vaccine is currently being tested.  

 

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Little Star

Thanks for the info MikeHerp and WilsoInAus, I’m spending way to much time on this forum,  hoping for better treatments, vaccines and that impossible cure.

Think it’s time for me to log off for a while and try and get back to living a normal life.

I’ve enjoyed reading your posts, keep searching and posting, I’ll drop in now and again. Little Star ️ 

Edited by Little Star

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