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Over 4 Years with HSV-2, Symptoms Keep Getting Worse with Non-Stop Outbreaks Despite Suppressive Therapy (Need HELP!)


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Low testosterone is no good for anyone, I recommend to get that treated if it remains the case.  I strongly don't recommend to take one shot of sustanon at any time. TRT is for life, temporary

Sure! From my understanding, E2 (Estradiol) can protect you from outbreaks while elevated Progesterone makes you more suspectible to outbreaks. However, another study says that elevated E2 levels can

17 hours ago, Mikeike3 said:

try one month to see if you get any relief ?

 

17 hours ago, Mikeike3 said:

try one month to see if you get any relief ?

I really am broke.  I don’t have that kind of money.  Amenavir costs more than my rent.  I wish I could try it.  

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My experiment with T3 has been working.  I am definitely fighting off the infection better.  Trained hard three days in a row, 5 mile job through hot desert, 30 min swims...  was feeling the flu/fever coming on as usual and am feeling fairly lousy today, but the T3 is helping big time.  I am definitely much less sick than I would normally be.  I took an extra drop last night post workout.  My heart was beating like a drum and I had a bit of insomnia, but I'm definitely not as bad as normal.  A bit flu/achy, but not so bad that I won't train again today.  I get mine from this place, https://idealabs.ecwid.com/    It's called tyronene.  I also get my methylene blue there.  That stuff helps me fight the fatigue greatly.  The name of that product is oxidal.  Very impressed with the T3 experiment so far. 

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6 hours ago, jmherped said:

My experiment with T3 has been working.  I am definitely fighting off the infection better.  Trained hard three days in a row, 5 mile job through hot desert, 30 min swims...  was feeling the flu/fever coming on as usual and am feeling fairly lousy today, but the T3 is helping big time.  I am definitely much less sick than I would normally be.  I took an extra drop last night post workout.  My heart was beating like a drum and I had a bit of insomnia, but I'm definitely not as bad as normal.  A bit flu/achy, but not so bad that I won't train again today.  I get mine from this place, https://idealabs.ecwid.com/    It's called tyronene.  I also get my methylene blue there.  That stuff helps me fight the fatigue greatly.  The name of that product is oxidal.  Very impressed with the T3 experiment so far. 

Do you check t3 levels or did you get baseline prior 

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On 11/14/2019 at 5:08 PM, Mikeike3 said:

Do you check t3 levels or did you get baseline prior 

 

On 11/14/2019 at 5:08 PM, Mikeike3 said:

Do you check t3 levels or did you get baseline prior 

I didn’t check.  I just read everything on pubmed about herpes and thyroid, and based on how I was feeling I felt that it might help.  The stuff I use is called tyronene, and it contains 8mcg per drop.  I take three drops each morning and have been using for over a month now, and I can say it has made a lot more resilient to the virus.  It is now part of my core arsenal of supplements which includes pregnenolone, dhea, methylene blue, valtrex, low dose naltrexone, adamantane with tylenol (its a flu medication on the shelf here in mexico), zinc, selenium, nac, and bht.  My diet is all based on antiviral foods as well.  A lot of olive oil, oregano, you name it.  

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On 10/30/2018 at 6:38 PM, viralfrog said:

I would strongly suspect you have some other condition than herpes. 

I've been tested whilst on antivirals and the results were as follows:

IgG: positive
igM: negative 

Btw I'll do some kind of a log once I get my BHT. 

I got tested for IgG and IgM which came back NEGATIVE for both, I took valcyclovir 2g around a month before testing and did a 7 days Valcyclovir course (1g tablet twice a day) around 4 months before testing. Do you think Valcyclovir affects HSV IgG test to be false negative? My partner also got tested, She is IgG negative (0.83) but IgM positive (3.5), she had chicken pix 3 months back. SI got tested for IgG and IgM which came back NEGATIVE for both, I took valcyclovir 2g around a month before testing and did a 7 days Valcyclovir course (1g tablet twice a day) around 4 months before testing. Do you think Valcyclovir affects HSV IgG test to be false negative? My partner also got tested, She is IgG negative (0.83) but IgM positive (3.5), she had chicken pix 3 months back. So we think it's a false positive for her IgM due to cross-reactivity. Any help would be appreciated please?o we think it's a false positive for her IgM due to cross-reactivity. Any help would be appreciated please? 

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  • 1 month later...
On 6/15/2019 at 11:19 PM, viralfrog said:

No improvements for me, still getting the same: constant redness on my penis, with tiny blisters forming as the old ones heal. This is together with continuous lethargy and a pulsating pain in my right groin lymph node. I also have sleeping problems, that are associated with the outbreaks. Usually, if the OB gets slightly better, I'll also sleep better. But right now, I wake up every morning too early like 6:30 feeling like my body is fighting something and I can't relax and sleep anymore. I get under 7 hours of sleep each night, but my body needs around 8-9 to feel normal. Unlike some others, I'm extremely sensitive to having enough sleep, which is also related to my heavy workouts. Of course it could be also the other way around, that I'm getting OBs because of poor sleep. 

I went to get my bloods tested about a month ago and everything came back as normal (full blood count, thyroids etc.) but I found my vitamin D levels were low. I've been since spending a bit more time in the sun (normally avoid it) and eating a Vitamin D3 supplement daily (5000iu) without improvements to my OBs. I'm so disappointed, as I already got exited being onto something after finding that low Vitamin D-levels are associated inability of the body to fight viral diseases. Based on my research, 5000iu of D3 for several weeks should've definitely increased the levels by now, so I doubt that was the cause :( . My testosterone and estradiol levels were also a bit high as I just changed testosterone medication, but I have confirmed in the past that this is not likely the cause. 

My cortisol level was 17.3 ug% measured around 2pm (normal 3.7-19.4 ug% before 10AM, 2.9-17.3 ug% after 5PM). This could suggest that my cortisol levels are a bit high, but they are quite hard to measure and change during the day. I recall @IcantThinkofaName you suggested measuring these. Any comments? This was on a week day without any physical activities beforehand, except riding to the lab on a motorcycle in hot weather. Anyways, I can't really find any info on how to reduce these levels apart of relaxing more. For the record, I have tried quitting the gym completely (etc.). 

I used some Xanax on the weekend which made me sleep well and feel much better. But obviously such addictive and strong benzodiazepine is not a long term solution. Next week I will try some cannabis to see if that helps with the sleep. I will get some indica strain and will vape it with a herbal vaporizer. 

I will not give up the fight, next to try on the list:

  • Confirm Vitamin D levels are back normal
  • Quit whey protein for a week 
  • Cannabis before bed 
  • Amenalief at a higher dosage (200mg/day)
  • Pritelivir from China
  • Singles/varicella vaccine(?)
  • ... any ideas welcome! 

Hey viralfrog

Hows it going? I took a hiatus from this site for awhile.

I agree with the others though...Cut back on coffee :D  It raises cortisol. Your afternoon cortisol seems a little high ( but not awful). what did the Dr say? I thinkyou are supposed to take that test in the morning..or do the saliva test that check it throughout the day??? If you can't sleep at night, it could be cortisol or adrenal problem too. But you said that sleeplessness was from HSv symptoms?

 I know, I love coffee too... If I have too much it fucks me up. ALso heavy weight deadlifts while fasting also seem to fuck me up/cause OBs. But combine those two with depression and wham bad OB.  I quit AVs  this summer and no Obs to report ...I seem to be better in summer, which tells me it has something to do with vitamin D levels or circadian rhythm. You are in Thailand so...totally different situation for you.

try:

CBD for sleep and relaxation

I like how you switched your workout times. better for your sleeping? 

I still think its a hormonal thing, or a co-infection you might have.. or some underlying thing that is weakening your immune system.  Heavy weight lifting while exhausted makes me have a breakout too...

write back..let me know how you are doing or if anything has helped.

I'm going to try nanosilver again I guess.

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On 12/28/2019 at 10:27 AM, IcantThinkofaName said:

Hey viralfrog

Hows it going? I took a hiatus from this site for awhile.

I agree with the others though...Cut back on coffee :D  It raises cortisol. Your afternoon cortisol seems a little high ( but not awful). what did the Dr say? I thinkyou are supposed to take that test in the morning..or do the saliva test that check it throughout the day??? If you can't sleep at night, it could be cortisol or adrenal problem too. But you said that sleeplessness was from HSv symptoms?

 I know, I love coffee too... If I have too much it fucks me up. ALso heavy weight deadlifts while fasting also seem to fuck me up/cause OBs. But combine those two with depression and wham bad OB.  I quit AVs  this summer and no Obs to report ...I seem to be better in summer, which tells me it has something to do with vitamin D levels or circadian rhythm. You are in Thailand so...totally different situation for you.

try:

CBD for sleep and relaxation

I like how you switched your workout times. better for your sleeping? 

I still think its a hormonal thing, or a co-infection you might have.. or some underlying thing that is weakening your immune system.  Heavy weight lifting while exhausted makes me have a breakout too...

write back..let me know how you are doing or if anything has helped.

I'm going to try nanosilver again I guess.

Hey there, thanks for the follow up. 

Can't live without coffee :D I just took that cortisol test on my own, not with a doctor's referral. I've started sleeping much better since switching my workouts for mornings. I monitor my sleep with an app and can see on the statistics it has made a massive difference. 

I'm actually happy to report significant improvement with my condition. It still hasn't gone away completely and I still get it on/off, but it's not like I'm feeling like crap 100% of the time anymore. I actually have plenty of days (even a full week almost sometimes) with no significant outbreaks. I have been experimenting with topical treatments that I posted about earlier that I still believe makes a difference (which is hard to believe). I also did some experiments with SADBE which seem to have further reduced the OB severity. I'm going to continue with this and will post a thread at some point once I have something conclusive. They are just formulating a new topical treatment (Squarex) and I'm doing the same right now (DIY at home). 

In any case I've started some hobbies again and been enjoying life a lot more recently. I've also cut down on all kinds of unnecessary supplements and just using Acyclovir 800mg mornings and evenings. 

I feel like I'm onto something and will definitely post an update at some point. 

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IcantThinkofaName
On 1/3/2020 at 9:21 AM, viralfrog said:

I'm actually happy to report significant improvement with my condition. It still hasn't gone away completely and I still get it on/off, but it's not like I'm feeling like crap 100% of the time anymore. I actually have plenty of days (even a full week almost sometimes) with no significant outbreaks. I have been experimenting with topical treatments that I posted about earlier that I still believe makes a difference (which is hard to believe). I also did some experiments with SADBE which seem to have further reduced the OB severity. I'm going to continue with this and will post a thread at some point once I have something conclusive. They are just formulating a new topical treatment (Squarex) and I'm doing the same right now (DIY at home). 

Thats excellent! 

Yeah, I don't doubt topical acyclovir that could work...perhaps better than oral for some.

I am interested in the Squarex and SADBE also. I  thought they were for HPV (which I also caught from my HSV giver) or cancer??  But I did read it helped for HSV somewhere I think?? My DR. would not prescribe it for off treatment indications however even though I have HPV 😡 How do you get them?

I'm glad things are better for you. Sleep is so important. I can see how working out in the evening could induce sleep problems..i used to work out from 7-10 pm, now I quit before 7pm...much better...those nasty fluorescent lights aren't good 

Keep up the good work and keep me posted!!!

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  • 1 month later...
On 10/20/2018 at 10:33 AM, viralfrog said:

Hi all,

I caught HSV-2 over 4 years ago. It was pretty typical in the beginning, with a major outbreak first and further ones that followed. However, I was able to keep them under control with Acyclovir 400mg/day suppressive therapy and 1000mg a day during outbreaks.

In the past year or so, it has been getting worse and worse. The outbreaks started on my penis but later I started getting them on my buttocks too. In the last few months, they have been present only on my penis but NON-STOP. As an outbreak clears an new one will start within a few days. I can feel swollen lymph nodes on my groin and I'm constantly lethargic with a fewer-like feeling. I have had a non-stop outbreak for the last 2 months! 

Lifestyle: Since 16 years old I eat very healthy (high protein, complex carbs, vegetables), excercise 4 times a week (fitness/bodybuilding) and sleep 8-9 hours per week. I don't drink alcohol, but do drink coffee daily. Apart of HSV-2 and being on HRT I am very healthy. 

Current daily drug / supplement stack to combat the virus:

  • Acyclovir 1200mg / 3200mg during outbreaks
  • L-Lysine 2000mg / 4000mg during outbreaks
  • Zinc 50mg
  • Vitamin C 1000mg
  • Multivitamin

Others I have tried without success: Valacyclovir 1000mg/d, CBD oil 

Other unrelated drugs and supplements I take that could have effects (since a long time):

  • Testosterone injections (I'm on HRT, due to testicular cancer I had at 18 years old)
  • Arimidex (control Estradiol levels)
  • Finasteride 0.5mg (reduce hairloss)
  • Fish oil
  • Whey protein
  • L-glutamine
  • 5-HTP (mood/sleep boost)

I have recently started researching the possible effects of the testosterone replacement therapy and the effects of hormonal balance on HSV-2 outbreaks. I found research indicating that increased Estradiol/Progesterone levels can trigger outbreaks (can share if anyone is interested). I got labs done and found the levels were elevated, so I increased my Arimidex dosage without success. 

I have not yet tried the following supplements: Coconut oil, Probiotics, Vitamin B-12, MonoLaurin. 

Any advice what to do next :(? I'm feeling terrible for 90% of my life at the moment. When I visit a doctor / hospital they just prescribe me Acyclovir at a lower dosage I'm already taking. 

Hello, if you still use this site, how are things a year and a few months later? Mines similar..first ob Sucked, then maybe one a year and three years in I start having them monthly at least. Can’t catch a break. Have tried diet modifications and all..daily suppressive therapy isn’t working anymore I guess, I’ve tried valtrex and acyclovir. Let me know, been having these constant obs for 9-10 months now 😭

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  • 1 month later...
On 2/7/2020 at 3:54 PM, KelsMichelle said:

Hello, if you still use this site, how are things a year and a few months later? Mines similar..first ob Sucked, then maybe one a year and three years in I start having them monthly at least. Can’t catch a break. Have tried diet modifications and all..daily suppressive therapy isn’t working anymore I guess, I’ve tried valtrex and acyclovir. Let me know, been having these constant obs for 9-10 months now 😭

Hey little update again. My condition has been significantly improved. I'm not 100% sure of the reason, but it could be that I've been regularly using the DIY SADBE solution to treat it. 

Anyways it's not completely gone, I still get outbreaks very often but they are just so much milder. Most of the lethargy is gone, which makes me a lot happier. 

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On 4/4/2020 at 7:50 AM, viralfrog said:

Hey little update again. My condition has been significantly improved. I'm not 100% sure of the reason, but it could be that I've been regularly using the DIY SADBE solution to treat it. 

Anyways it's not completely gone, I still get outbreaks very often but they are just so much milder. Most of the lethargy is gone, which makes me a lot happier. 

Happy for you dude- I hope it keeps getting better. Hang in there

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  • 3 weeks later...
On 10/26/2018 at 12:32 AM, Quest said:

I would get a Mary shoman sp? Link to her blogs. 

 I think you should see all of the Dr. Berg.

Thyroid challenges are very common with over the top viral obs

 

 

OMG this may be breakthrough for me! So I was diagnosed HSV2  a few years ago, had my initial OB, then one month later another, but then nothing for almost 2 years.  Then all of a sudden this last year it's been almost an outbreak every month and very frustrating - not terrible but when you go from never getting them to all of a sudden once a month I couldn't figure out what changed.  After reading this post I realized I stopped taking my thyroid meds during my 2 month job training a year ago and never went back on them.  Seems like my hormone balance may have been the thing keeping my outbreaks at bay, and then once I stopped taking it they are constant.  I never put two and two together but wow! This might just be the issue.  I need to make a dr appt and have my thyroid checked again - thank you so much for this info!!

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  • 6 months later...

Little update here again, it's been a while. 

Unfortunately I'm still suffering from this problem very bad. The only improvement I've had is rather than having an active outbreak every day, every week of every month, I now get some occasional better days. With better days I mean days where I feel normal. Other days (like right now) I'm just sweating, tired, pain on my right groin lymph node and feeling really shit. 

Those few days I've had where I've felt better have been amazing. Last weekend I went to hike on a mountain, it was great. But getting back into the week and an outbreak is back. It's still always the same, mild-to-severe redness on my penis and foreskin and very small bumps/blisters. The amount of redness is directly related to my overall feeling - I can feel my body is fighting something. 

I'm getting quite desperate with this now. 

ps. little trick I found that might help someone; put fine activate charcoal directly onto an outbreak. This seems to clear it overnight, but for me it comes back. It could be useful for someone with a large blister. Could also put it and then cover with a plaster. 

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  • 4 weeks later...

Another little update: I'm doing a little experiment and stopped antivirals completely over 20 days ago. I don't notice any difference at all to my outbreaks.  This would suggest that I have an ACV resistant stain, which from my research, are getting more common. 

I feel like I'm down to three possibilities overall: 

  1. I have an ACV-resistant strain of HSV-2 and my body is poor at fighting the virus 
  2. I have some kind of immune or hormonal issue that I have failed to identify
  3. I have something else than Herpes.. 

I've been really struggling with option 2 as I've been to many tests and everything shows I'm normal and healthy. I would wish for option 3 to be possible, but then again I can't figure out what else could it be. Everything else apart of my OB frequency points to HSV-2 and I have tested positive by two blood tests and one swab. 


 

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  • 2 weeks later...

Over 30 days without antivirals. I see absolutely zero difference to my outbreaks. Too early to say yet as I've been on holidays which typically has a somewhat positive effect due to reduced stress, but I feel like I'm more energetic as usual. 

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40 days without antivirals. Developed a large outbreak on my right buttock (same side as I get the swollen lymph node on normally, which is also swollen right now even more than usual). 

So I basically have two types of outbreaks: 

  1. The constantly active one on my penis, which is the same area as my first ever outbreak. 
  2. On my right buttock. This one I get very rarely and only when I stop antivirals (during the past 2 years). I actually got it right now after I stopped ACV for a month.

Number 1 is very atypical and doesn't react to antivirals. 2 on the other hand seems like a regular case of HSV-2. Is it possible for a person to have two different strains of HSV-2 simultaneously? This is very confusing. I read a study about ACV-resistant HSV-2, where it was actually mentioned that they identified both ACV resistant and non-resistant viruses from the patient. The patient had infected their partner, but with the ACV non-resistant strain. 


 

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