Full paper here: https://www.sciencedirect.com/science/article/pii/S0264410X18315652
Note sure if anyone wrote about this. I couldn't find any results for VC2 in the site's search. This is a live attenuated vaccine from Louisiana State University. The results do not seem super promising, as reducing shedding/recurrance by < 70% pre-clinical is common in many discontinued vaccines. Still, research is being done, which is always great!
"Our studies also showed that VC2 vaccine decreases the clinical severity of acute and recurrent HSV-2 disease in guinea pigs when provided by intramuscular vaccination. During the primary infection, animals vaccinated with VC2 had a significant decrease in clinical severity and replicating virus in the vaginal vault. Prophylactic vaccination also decreased the quantity of virus in the DRGs when compared to the No Treatment group. The ability to protect neural tissue from latent infection probably contributed to the decrease in the number of animals with recurrent lesions by 67% and the number of days with recurrent vaginal shedding by 46%. This reduction in shedding is particularly important because transmission of HSV-2 to uninfected persons is largely due to asymptomatic shedding , ."
"When tested as a therapeutic vaccine, i.e., one designed to decrease recurrent disease and recurrent virus shedding in those already infected with HSV, the VC2 vaccine was not effective although it did reduce recurrent shedding, at least when compared to the gD2 vaccine. This may be because live attenuated vaccines have only limited replication in hosts that are already infected and thus do not have much of an impact in improving the immune response. Because infected hosts have frequent reactivations of virus that would be similar to a live vaccine inoculation it may be difficult for the vaccine to improve the immune response unless it is able to induce responses not activated by the host’s recurrent virus replication."
Hi..Ive been browsing around the web, and find out that HSV1 might caused eye infection and ultimately blindness..how common is this? Anyone experiencing this before?
I just being diagnosed with hsv-1 (oral) and experience my first outbreak. What worry me is that i am on my early stage of pregnancy, is there any risk i transmit the virus to my baby in the uterus? Since I never had any outbreak before and this is the 1st time I've been tested positive with hsv-1. Anyone could help me deal with this, Im so worry, I really want to make sure my baby is delivered safe and healthy
I've never had a herpes sore or any symptom in my entire life.
Last week I receive a small spit of saliva in my lip when I am talking to a friend who has active sores. After that I "run" to the bathroom and washed my lips with lots of water.
So far I have had no symptoms, whem exceed the incubation period of 20 days and I have NO symptoms , I can rest?
Please give some advice! What I have to do to get peace in my head? or tell me if this episode is a risk of transmission?
Thanks for your support
I just got what I am calling first OB last week. I'm stunned, depressed, sick... list goes on and on. Had several partners before marriage .. been married for 15 years. I've never cheated. Don't think he's cheated or he even was with anyone before me. But I wouldn't bet my life on any one other my own actions. But he's a pretty good guy and promises he has not. I'm in so much pain, I can't breath hardly. Dr says it's for sure herpes. I am awaiting test results. Started Valtrex. I can't even hardly look at my husband now. He's being so sweet and worrried about me but I just want this to go away. Help please. Where do you go from here? Does he for sure need tested ? I don't want to make him sick if he's not and now that I'm having OBs I'm afraid I'll make him sick if I ever have sex with him again. Tests sound like they won't show if he's already carrying it if he's not symptomatic... ??? Im afraid my kids are carrying without knowing now. Want to die almost. How do I go back to my church and my work like this isn't taking over my life ??