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Has anyone heard or tried levamisole?



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Interesting find.  Its likely that the drug was simply overshadowed by the arrival (and significantly better efficacy) of the nucleoside analogs (Vidarabine, Acyclovir) around the same time. 

The metrics shown in the study (i.e. a 33% reduction) doesn't exactly warrant a call to arms.  The efficacy of acyclovir for the same purpose is >2X and attacks the virus directly. 

This was also a relatively small study.  Care has to be taken putting too much stock into small preliminary studies many years ago.  Often what happens is: a follow-up study is run, the treatment doesn't live up to the hype, and the results aren't published.

That being said, given their mechanism of action, the combination of Levamisole and Acyclovir may be complimentary for a single unrelenting outbreak.  The challenge is that it doesn't sound like Levamisole is supposed to be taken long term and a single course isn't going to be a cure.

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