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Delivery of antiviral chemotherapeutic agents to neurons by retrograde axonal transport

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readytostart
Cas9
readytostart

I was aware of the years of publication, thanks.... I posted because I thought there was no way to reach the ganglia with medication, and it seems it may not always be the case.

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floydmonk

I think you are in the right track. A delivery mechanism is key, but that also depends on what you are delivering. It’s definitely worth bringing this up, recent studies have found things like Bx795 which can clear the infection from cells, including nerve cells, but it would have to be delivered directly to those cells without off target impacts. 

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ManagingIllness

https://www.ncbi.nlm.nih.gov/pubmed/12696114 (2003)

https://books.google.ca/books?id=VzvUBwAAQBAJ&pg=PA146&lpg=PA146&dq=doxorubicin+hsv&source=bl&ots=zJdxbeH6Sg&sig=t2GzP2ci-e_Qm8IffhxqI2TL5HY&hl=en&sa=X&ved=2ahUKEwjptdb20vjeAhXi24MKHcxdAaU4ChDoATADegQIAxAB#v=onepage&q=doxorubicin hsv&f=false (1992)

"Injection of the anthracycline antineoplastic drug doxoribicin directly in the nerve of rats resulted in nerve cell body destruction... including those neurons infected with HSV... Bystandard neuronal cell death and dense sensory lose would be an unacceptable consequence of ricin therapy..."

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