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Vaccine cure

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Roja

But they inoculated with HSV AFTERWARDS, no? 

 

"The results 4 sets of experiments with three mice per group were conducted (12 mice in each ‘treatment’ group and 9 mice in each ‘control’ group). Mice were vaccinated on Day 0 with either:

- treatment (CPP-antigen) + adjuvant (There were two separate treatment groups – one using Phylogica’s CPP and another using Tat);

- antigen alone (no CPP) + adjuvant;

- adjuvant alone (no CPP and no antigen); or

- a negative control (no CPP, no antigen and no adjuvant)

Mice were then inoculated with HSV on day 7. Mice were culled on day 13 with tissue samples taken for completion of viral titre assays (measurement of viral burden within those tissues). The results of the experiment are displayed in Figure 2."

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LeftCoast
13 minutes ago, Roja said:

But they inoculated with HSV AFTERWARDS, no? 

 

"The results 4 sets of experiments with three mice per group were conducted (12 mice in each ‘treatment’ group and 9 mice in each ‘control’ group). Mice were vaccinated on Day 0 with either:

- treatment (CPP-antigen) + adjuvant (There were two separate treatment groups – one using Phylogica’s CPP and another using Tat);

- antigen alone (no CPP) + adjuvant;

- adjuvant alone (no CPP and no antigen); or

- a negative control (no CPP, no antigen and no adjuvant)

Mice were then inoculated with HSV on day 7. Mice were culled on day 13 with tissue samples taken for completion of viral titre assays (measurement of viral burden within those tissues). The results of the experiment are displayed in Figure 2."

I am so confused, I don't know shit about peptide vaccines. Is this a prophylactic or therapeutic vaccine?

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Newone2
2 hours ago, readytostart said:

we all should meet and have a beer when all this gets finally resolved :)

First round is on me :thumbsup:

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LeftCoast

I’m going to call the company in a few hours and try to get some more information. It’s 4:30 in the morning in Australia right now. 

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JHenry
6 hours ago, LeftCoast said:

I am so confused, I don't know shit about peptide vaccines. Is this a prophylactic or therapeutic vaccine?

That is my same question. Of course I am hoping that it is prophylactic and therapeutic.    I have emailed the CEO and while I’m not anticipating a response, should I get one I will immediately share it.  Henry.

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Roja

To me it sounds preventive :/

8 hours ago, LeftCoast said:

I am so confused, I don't know shit about peptide vaccines. Is this a prophylactic or therapeutic vaccine?

 

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LeftCoast
8 minutes ago, Roja said:

To me it sounds preventive :/

 

As mentioned folks, I am going to call the company later on today (it's super early in Australia). I am not a scientist so I don't really know how peptide vaccines work. However, it seems like other types of peptide vaccines can be either therapeutic or prophylactic. Let's not jump to any conclusions until someone gets an email back or is able to make a phone call. 

Edited by LeftCoast

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JHenry
2 hours ago, Roja said:

preventive :/

 

I know next to nothing about “science”, but it seems that if it would attack on the prophylacticly, couldn’t it also work therapeutically?    Wishing, hoping, praying..

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raka

Hope it cures the disease. Really we need a  cure.

Edited by raka

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Puni

Guys this is therapeutic, rear the pdf , they are able to attack the virus in the nerve dendrite cells , basically they are able to cross the bloodbrain barrier.

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Roja
5 hours ago, Puni said:

Guys this is therapeutic, rear the pdf , they are able to attack the virus in the nerve dendrite cells , basically they are able to cross the bloodbrain barrier.

that would be... I mean....  :happydance:

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Miss Horne

I would like to know what does WilsoInAus, MikeHerp, Cas9 and StayingUpbeat think about this, please share your thought on this. Thank you. 

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LeftCoast
1 hour ago, raka said:

@LeftCoast

Any update?

Nope! It’s the weekend. Research facility is closed! (Everyone needs relaxation amirite?) I’ll call on Monday. 

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raka

This is not yet proven for therapeutic.


Certainly the concept that sits behind the vaccine approach (expansion of viral-specific CD8+ T-cells) is applicable across the two strains of HSV (and beyond). Before we could commit to HSV-2 as a therapeutic application though, two things would need to happen:

1) we would have to demonstrate that the 'prophylactic' protection conferred in the animal model described (in which the vaccine is given before exposure to the virus) translates to 'therapeutic' protection (in which the viral exposure occurs before the vaccination); and

2) we would have to make the strategic decision to pursue HSV-2 as the best application of the technology - many before have gone down that path with limited success in the clinic (https://www.fiercebiotech.com/biotech/more-bad-news-for-vical-as-it-abandons-herpes-vaccine-program).

We will obtain the competitive read-out with the Amal CPP in the first instance and then present that data in Vancouver in January at a conference of leading experts. On the back of that, we will make the call as to how we want to proceed with the program so we should be in a position to give you more colour early next year.

Kind regards,

Rohan

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Trace67

Its way to early to know how this will work in humans. Its interesting but its going to be quite a while. Add it to the 10 year list and hope it doesn't stay stuck in there with the other perpetual 10 year vaccines. Also, HSV may be better able to evade in the human body.

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  • The Hive is Thriving!

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    • Jayne
      I know this thread is a couple of years old, but it’s been helpful to me, and I wanted to contribute as well. Back to Berliner’s original post, I’ve tested negative on several IGGs, with the latest ones being 1 yr and now almost 2 years past exposure.  Figuring out what was going on was the worst nightmare I’ve ever been through in my life. I made the mistake of drinking heavily a week after my father died of cancer, and I had unprotected AS with an ex, who happened to be poly and had some occasional unprotected M2M encounters.   Three days later I had a red line rash along my (sorry to get explicit) crack. This was followed by a rectal burning. Tested negative for G&C and related tests.  Over the next couple of weeks I had severe swelling and discomfort in my lower right quadrant and was told to go to the ER, where (I guess as a standard practice) they did a cat scan, which revealed nothing.  Also not a bacterial infection.  However the repeated manual examinations that occurred at urgent care and the ER seemed to relieve the abdominal pressure over the next few days.  I then had diarrhea for the next several weeks after.  I developed what felt like internal hemorrhoids, which were exacerbated by the diarrhea, and a gastro doctor confirmed via digital exam that there was indeed some sort of mass that felt like possible hemorrhoids. He ordered a sigmoidoscopy, but by the time it was undertaken, whatever was there was gone. After the procedure though, I felt much better for a while, possibly due to digestive issues clearing up after the colon “cleanse.” But this was concurrent with other issues.   About 3 weeks after the encounter I developed a large rash on my left thigh. Shortly thereafter I started having light sensitivity issues, culminating in a fever-like state after being outside in the sun only for 15 minutes after work. At work around that time for a couple days I felt like I was going through life encased in a gauzy gel- similar to being on laughing gas at the dentist, but not in a good way. I didn’t know what the hell was happening to me. I developed a severe case of canker sores for about a day. Later during a sunny drive, after getting back in the car at a gas station I noticed a red blotch below my lip. I tried to shrug it off but it happened again on the trip back.  So by about a month after the encounter I was having more anxiety. I spent the night at a friend’s house and woke up with a massive, swollen red eye and swollen lips. I got eye drops for bacterial conjunctivitis but that was wishful thinking.  A couple of weeks later, my lips were covered in sores. I smothered them with abreva. By the next day, they had mostly gone away. I tried to do a swab test at urgent care (I believe it was the next day), but there was not enough there to make any sort of positive diagnosis. Since then, I’ve had what you could call repeated aborted lesions and red blotches that appear around my mouth, particularly after stress and alcohol consumption. But even having peanut butter or chocolate would set it off for a long time. Fair skin doesn’t help- there was no hiding it. Two months after the encounter, I had my first vaginal burning- it was pretty intense and I had to use ice cubes because I didn’t know what else to do.   The worse feeling though was the periodic flare-ups of rectal itching/burning, often accompanied by another red line rash. It made sitting uncomfortable for about the next two months. I couldn’t wear pants at work- only skirts seemed to make things somewhat less irritated. And for the first three months, I was still testing for HIV along with HSV because of the overlapping symptoms (rash, diarrhea, neural pain, severe flu like symptoms without fever). I lost a lot of weight and had panic attacks. On top of all this I had just moved to a new city and started a new job and didn’t have a support network. And the sad thing is, I had to deal with all of this instead of being able to grieve for my father and being a better source of support to my mother. She had to support me without understanding what was happening.   Another bad thing through all of this was having both my ex and my current partner treat me like I’m crazy. That makes me feel alone and in the dark. Another “hysterical woman.” F*** that.  And while I felt grateful that my current was at the time still ready to be with me even if I had hsv, it’s a little discomfiting that he still doesn’t really believe me. But I’ve learned to live with ambiguity. And now I’m used to doctors as well as partners acting like this is nonexistent. Especially with negative IGG tests even 2 years later, which have left me without any answers.  I’m lucky in a way to be able to blend in because I don’t get obvious sores, genitally or orally (I can cover up the blotches with concealer, and they fortunately have lessened in frequency). But I still get the rectal itching/burning every six months or so (anthistamines seem to alleviate it a bit). And as more of a concern, I’ve had a cramp in my lower right quadrant ever since, which feels like it’s in my digestive tract. Since this has pretty much spread everywhere else in my body, intestinal involvement wouldn’t surprise me, and it isn’t unheard of anyways. I’ve tried to move past this and have since gotten married to my partner, who is a source of support (even if he doesn’t believe I’m having health problems. I know that’s a contradiction but occasionally I want to believe that too.).  I’m also newly pregnant, and symptoms have started to flare up again somewhat. I’m sure this will be an adventure. Hopefully more good than crazy. I know I’m going to struggle with the fear of passing this along but I’m trying to reconcile what doctors say (which is that it is extremely rare) with my own intuition about what I need to be careful of. Maybe I’ll repost with an update down the road. In short, there are people out there who test negative and have to live with loved ones and doctors thinking that a negative test closes the book on this. Again, learning to live with ambiguity is a real life lesson that I’m still coming to grips with. This forum and specifically this post have been a source of comfort that I haven’t been able to find elsewhere. Thanks everyone for the support for the community.     
    • Rockster
      You deepthroat so good that you get all kinds of mouth-to-skin-of-base contact? Kudos to you, but that is extremely rare. 
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