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MikeHerp

Genocea ... withheld negative trial result?

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Cas9
2 hours ago, Shandawgs said:

This doesn’t look good, more of my hope diminishing :(

Why is your hope diminishing? This vaccine was never a big hit in the first place. There are lots of other vaccines and research going on that are more promising. Remember, all it takes is one to be successful. It will be a while, but I would say that sometime in the next 5 to 10 years things will be very interesting.

I got hsv when I was 28; that was 1982. If the research going on then was like it is now, I would have been elated.

How old are you?

Edited by Cas9

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Kurdt01

I was in the trial...had a negative experience and others did too....so yeah I’d believe they were with holding....it’s why none of these go forward...either vaccines aren’t the answer or they have a lot to figure out....the people they help are the outliers...not the ones they harm.

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MikeHerp

Cas9 is correct.  I just posted this information as a matter of curiosity to members, not to "crush anyone's hopes" .  I'm well over the Genocea disappointment and agree there are more interesting things going on in HSV research.

At best, GEN-003 would have provided a modest benefit.  It would have certainly been nice if it had gone forward and been approved, thereby providing another option.  But it's not the end of the world that it didn't.  

The road to treatment success, will be littered with fails along the way.  Some of which will point to the need for a different strategy.  It's important to have GEN-003s along the way, in order that we get better treatments.  

I'm reminded of Akiko Iwasaki's recent published research, which seems to suggest why certain therapies haven't been effective against neurotropic viruses, pointing to the need to concentrate on certain CD4 cells whcih can pave the way for antibody access to nerves.  This could help explain why most of the therapeutic vaccines haven't enjoyed success.  GEN-003 did elicit CD4 cells, but were they the right ones?  Was Genocea's focus correct in light of Doctor Iwasaki's research?  Perhaps not.

 

"Emerging evidence indicates that CD4+ T cells can pave the way to antibody access in immunoprivileged tissues by reducing the BBB and BNB. On the one hand, transient access by antibodies is necessary for protection against neurotropic viruses. On the other hand, chronic access by antibodies to neural tissues can drive autoimmune diseases (see Box 3). We can leverage this information for the design of rational vaccines and antibody-mediated immunotherapy against neurotropic viruses and brain tumors."  

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MikeHerp

Anyway, if anyone has access to a WestLaw account and can read the full text of the court decision, please post here.  It's just something I'm curious about--what the hell exactly happened to Genocea and GEN-003.  

GEN-003 seems to have been dead in the water for many months now but I'm just curious what exactly happened there.  

Interestingly, Genocea at their last investor conference call, insisted that they still have talks ongoing about GEN-003.  In that context, I wonder what exactly it was that they didn't disclose to investors and whether these alleged discussions are just smokescreens to maintain investor interest in the company.  Last I checked, GEN-003 isn't even mentioned on Genocea's website, so what could they possibly be talking about.  

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f*ckedOver
StayingUpbeat

This was a lawsuit fishing expedition executed by a type of law firm similar to an internet spammer.  They throw all manner of low probability suits against the wall with the hope that a few of them will stick enough for the company being sued to pay them to go-away.

As expected the lawsuit was thrown out in the first phase of court filing (see below).  Having watched very closely the Genocea clinical trials they were done about as ethically as possible and their reporting of results was done totally above board.

https://www.reuters.com/article/health-genocea/genocea-biosciences-ducks-investor-lawsuit-over-herpes-vaccine-idUSL1N1YC215

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MikeHerp
45 minutes ago, StayingUpbeat said:

This was a lawsuit fishing expedition executed by a type of law firm similar to an internet spammer.  They throw all manner of low probability suits against the wall with the hope that a few of them will stick enough for the company being sued to pay them to go-away.

As expected the lawsuit was thrown out in the first phase of court filing (see below).  Having watched very closely the Genocea clinical trials they were done about as ethically as possible and their reporting of results was done totally above board.

https://www.reuters.com/article/health-genocea/genocea-biosciences-ducks-investor-lawsuit-over-herpes-vaccine-idUSL1N1YC215

Yeah, I think you're right.  Another source that I read seemed to suggest that it was just an allegation that they didn't disclose something, rather than a proven fact.  

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