Jump to content
World's Largest Herpes Support Group
Roja

Shedding and Transmission: Numbers

Recommended Posts

Jill71

Its asking me to sign in.   Sounds interesting though!

Share this post


Link to post
Share on other sites
Constant Diplomat

Yeah I'd have liked to read these lower stats too. Can you copy and paste?

Share this post


Link to post
Share on other sites
Roja

Here you go: 

"This randomized, placebo-controlled trial involved the study of nearly 1500 immunocompetent, heterosexual, monogamous couples who were serologically discordant for HSV-2 infection. HSV-2-seropositive partners were randomized in a 1:1 ratio to receive valacyclovir 500 mg once daily or matching placebo.[19]Condoms were provided free of charge to all participants in the trial throughout the study, and all couples received counseling about the effective use of condoms. HSV-2-seronegative, susceptible partners were evaluated monthly for 8 months for clinical and laboratory evidence of HSV-2 infection. New infections were diagnosed on the basis of isolation of HSV-2 from culture or HSV-2 seroconversion. Of 1498 couples at 96 centers worldwide, 1159 completed the study. During the study period, a total of 41 HSV-2 infections occurred among susceptible partners: 20 were clinically symptomatic and 21 were diagnosed on the basis of HSV-2 seroconversion only ( Table 3 ).

Of the 20 symptomatic infections, 16 occurred among the 741 partners of placebo recipients (2.2%) and 4 occurred among the 743 partners of valacyclovir recipients (0.5%) (relative risk, 0.25; 95% CI, 0.08-0.74; P = .01) (Figure 2). The time to development of symptomatic first episodes of genital herpes was significantly longer among the partners of valacyclovir recipients than among the partners of placebo recipients. In all 41 cases of HSV-2 acquisition that were evaluated, HSV-2 had been acquired by 27 of the susceptible partners of placebo recipients (3.6%) compared with 14 of the susceptible partners of valacyclovir recipients (1.9%) (hazard ratio , 0.52; 95% CI, 0.27-0.99; P = .04) (Figure 2).

Consistent with the findings of other studies of HSV-2 transmission, more female partners than male partners of placebo-treated patients acquired HSV-2 infection (7.4% vs 1.8%).[19] No evidence of a significant difference in treatment effect of valacyclovir was seen between susceptible female or male partners. There were several significant factors that influenced the effectiveness of the medication, however. Valacyclovir-treated persons who had genital herpes for less than 2 years were nearly 3 times more likely to transmit than those who had genital herpes for more than 2 years. Similarly, those who were in a monogamous relationship of less than 2.5 years' duration were also 3 times more likely to transmit infection. Interestingly, past HSV-1 infection was not a factor in protecting against the acquisition of HSV-2.

Condom use data were collected during the course of the trial.[19] Couples were classified, on a monthly basis, as those who never used condoms, sometimes used condoms (1% to 90% of sexual contacts), and nearly always used condoms (> 90% of sexual contacts). In the study population as a whole, frequent condom use was found to reduce the acquisition rate of genital herpes infections. Of interest, the effect of valacyclovir was similar among all frequencies of condom use. While the numbers were small, there was no evidence of transmission among couples who used condoms very frequently (> 90%) and also received valacyclovir (Figure 3); the study was not powered, however, to confirm that utilization of both modalities was 100% effective."

 

Share this post


Link to post
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.


  • The Hive is Thriving!

    • Total Topics
      69,571
    • Total Posts
      468,649
  • Posts

    • WilsoInAus
      That's exactly right, you can return to your life and get the blood test as a sleep easy in 12 weeks time (from the last episode).
    • Laurenhelena
      Him and his ex have regular breakouts with all the traditional symptoms and I believe he was swabbed.  So I can return to life as it was before all of this drama ? I may still look into a blood test is I am confident it is accurate 
    • WilsoInAus
      @Laurenhelena how is this guy sure he has herpes? All sounding a bit odd to me. Yes it is very unlikely you will develop lesions now. Rubbing skin to skin is required for any feasible transmission chance. The odds of transmission with unprotected vaginal sex are of the order of 0.08% per epsiode. Halve this if a condom is worn. Compare that to chamydia that has about a 33% chance of transmission with unprotected sex; now that's contagious!
    • Laurenhelena
      I just feel that it’s known as such a contagious STD - I’ve been lying to my family cause when I tried to talk about it they became very anxious and begged me to tell them I hadn’t slept with him when I had - If someone told me that they slept with someone with genital herpes my mind would instantly think they had it.  So it’s unlikely then that I’m going to get symptoms now? I’m not going anything further with that guy but we have cuddled and kissed in bed with underwear on, is that ok?  Im quite sure he has hsv2 given that his ex gave it to him through a threesome  I’ve never had a cold sore   
    • WilsoInAus
      Hey @Laurenhelena i think by your own admission you are letting fear get the better of you. Any flu symptoms (immune toxic shock) happen after the lesions, not before. Remember that most instances of sexual activity do not result in transmission of herpes. In the end it takes one exposure... but how many times has the person received oral sex from someone with HSV-1? or had sex with someone with HSV-2 even if they didn't know it was present? The UK has amongst the lowest incidence of genital HSV-2 in the world! There's a very good chance he has HSV-1. This means much lower transmission chances than you might think and even a chance it is near zero if you have an oral HSV-1 infection yourself!
×
×
  • Create New...

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.