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raka

Any update by Keith Jerome page on the research? or do we know when we can expect next update on his research?

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IAmDesperate

Everyone, do you believe that Keith Jerome's gene therapy enter human trial next year? Maybe the middle of next year? I know he still needs to do the toxic and IND submission. Btw how long does IND submission take? I just wanna know your opinion, no arguing please.

3 hours ago, MiLoBeng said:

Probably next year?

I hope it could be the end of this year :(

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Cas9

Human trials starting next year?  Not even close. It will be several years.

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StayingUpbeat
On 6/20/2019 at 4:44 PM, Franky26 said:

i emailed bill gates foundation and this is was there response 

 

Thank you for contacting the Bill & Melinda Gates Foundation.

Although we appreciate your commitment to this cause, unfortunately, we are unable to fund your efforts. The foundation makes grants to organizations directly rather than through individual fundraising activities.

As you may already know, the foundation’s work stems from our belief that all lives have equal value. We think all people deserve the chance to live healthy, productive lives. In developing countries, we focus on improving people’s health and giving them the chance to lift themselves out of hunger and extreme poverty. In the United States, we seek to ensure that all people—especially those with the fewest resources—have access to the opportunities they need to succeed in school and life.

For more information about the foundation, please visit www.gatesfoundation.org.

We wish you success in your efforts.

Sincerely,

Bill & Melinda Gates Foundation
www.gatesfoundation.org

It should be noted that the Gates foundation was part of a venture capital group that gave Genocea $30 million in support of their vaccine development efforts in the period when their lead candidate was an HSV-2 therapeutic vaccine (GEN-003): https://xconomy.com/boston/2012/10/10/genocea-snags-30m-from-gates-foundation-vcs-for-new-vaccines/

They have also provided 30 million dollars to the University of Washington's HSV efforts.  This time specifically on research into whether suppressing HSV results in a reduction in HIV transmission: https://honeycomb.click/topic/77503-donations-to-fred-hutch-center/page/21/?tab=comments#comment-493474 

Far from inactive in HSV research they provide significant funding in the context of reducing HIV transmission.  It's a well established fact that genital HSV greatly increases the probably contracting HIV from an infected partner.

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MiLoBeng
8 hours ago, IAmDesperate said:

Everyone, do you believe that Keith Jerome's gene therapy enter human trial next year? Maybe the middle of next year? I know he still needs to do the toxic and IND submission. Btw how long does IND submission take? I just wanna know your opinion, no arguing please.

I think they'll enter human trial by 2023 or later but due to their success on achieving 90% elimination rate in just 2yrs. Who knows and it might happen sooner than you think. Cheers

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Freefalling87

So I noticed on Facebook they offer fundraisers to organizations of your choosing for birthdays. I tried to enter in Keith Jerome but didn't see him listed as an option, but Fred Hutchinson in general was listed. @MikeHerp do you think you could ask your contact to see how she could get Facebook to list them? 

Also, would you mind seeing if she could get this fundraiser listed on smile.amazon.com donations? I'd like to try it out for my birthday down the road. Hopefully they state it in a way that isn't so stigmatized (make it not say genital herpes but hsv in general with a list whether it is cold sores, ocular, genital, how it affects babies, etc.). That way, maybe more people would be more opt to share it on their pages.  😀

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LightafterDarkness

Looks like the fundraiser just passed the $25k mark. At some point this money starts to become really meaningful (e.g., $50k may pay for one additional person to work in the lab etc). Also its a signal from the community that there is alot of interest in a cure via gene therapy.

http://engage.fredhutch.org/site/TR?px=1709211&fr_id=1574&pg=personal

 

 

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iFdUp

To all the people estimating 2023 for human trials of what Dr Jerome is working on, we really have to see. 

Depending on what is happening right now about that 90% delivery to the SCG and the 50% to TG

As soon as it is considered an effective cure in mice it will move to a greater animal. 

The time to determine results of the mice testing was at most around 45~ days per test grouping. It may be longer for greater animals but I doubt it would be much longer. 

If the same level of efficacy is found in the greater animals it may progress to clinic much faster. It may even be granted access to certain people with rare cases of lethal herpes, anything is possible. 

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    • iFdUp
      To all the people estimating 2023 for human trials of what Dr Jerome is working on, we really have to see.  Depending on what is happening right now about that 90% delivery to the SCG and the 50% to TG.  As soon as it is considered an effective cure in mice it will move to a greater animal.  The time to determine results of the mice testing was at most around 45~ days per test grouping. It may be longer for greater animals but I doubt it would be much longer.  If the same level of efficacy is found in the greater animals it may progress to clinic much faster. It may even be granted access to certain people with rare cases of lethal herpes, anything is possible. 
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    • LightafterDarkness
      Looks like the fundraiser just passed the $25k mark. At some point this money starts to become really meaningful (e.g., $50k may pay for one additional person to work in the lab etc). Also its a signal from the community that there is alot of interest in a cure via gene therapy. http://engage.fredhutch.org/site/TR?px=1709211&fr_id=1574&pg=personal    
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