Jump to content
World's Largest Herpes Support Group
Bigtime

Squarex cream, compound already available online?

Recommended Posts

Bigtime

I read the thread on the Squarex cream and watched the video posted there. In that video the Squarex representative states that the cream is a known compound that he tried on himself for frequent oral outbreaks. With a little digging i found two Squarex sponsored studies for a cream for hsv-1 of a compound that is already available to buy through online pharmacies. SADBE or Squaric Acid Dibutyl Ester. Can someone with more knowledge on this check out these two studies and give their two cents whether this is the same compound the Squarex cream discussed in the video from the biotech conference earlier this month?

Heres the video

https://m.youtube.com/watch?v=XuSUe-rfqCk

And here are the studies

https://clinicaltrials.gov/ct2/show/NCT03661541

https://clinicaltrials.gov/ct2/show/NCT03521479

Thoughts?

Share this post


Link to post
Share on other sites
VladimirM
On 1/13/2019 at 7:10 PM, Bigtime said:

I read the thread on the Squarex cream and watched the video posted there. In that video the Squarex representative states that the cream is a known compound that he tried on himself for frequent oral outbreaks. With a little digging i found two Squarex sponsored studies for a cream for hsv-1 of a compound that is already available to buy through online pharmacies. SADBE or Squaric Acid Dibutyl Ester. Can someone with more knowledge on this check out these two studies and give their two cents whether this is the same compound the Squarex cream discussed in the video from the biotech conference earlier this month?

Heres the video

https://m.youtube.com/watch?v=XuSUe-rfqCk

And here are the studies

https://clinicaltrials.gov/ct2/show/NCT03661541

https://clinicaltrials.gov/ct2/show/NCT03521479

Thoughts?

You can buy SADBE (Squaric Acid Dibutyl Ester) now. Although not intended for HSV, it is essentially the same compound in essence. I bought it for my HSV. And he works great.

https://www.enbipharma.com/en/sadbeforte

Edited by VladimirM

Share this post


Link to post
Share on other sites
MikeHerp

ok, but it clearly says in the clinical trail info that it's suspended.  

 

Recruitment Status  : Suspended (More delayed type hypersensitivity responses (DTH) observed than anticipated.)

First Posted  : May 10, 2018
Last Update Posted  : August 3, 2018

Share this post


Link to post
Share on other sites
VladimirM
9 minutes ago, MikeHerp said:

ok, but it clearly says in the clinical trail info that it's suspended.  

 

Recruitment Status  : Suspended (More delayed type hypersensitivity responses (DTH) observed than anticipated.)

First Posted  : May 10, 2018
Last Update Posted  : August 3, 2018

There is another study.

It appears that the application on the face is suspended, but the application to the upper part of the arm is completed.

https://clinicaltrials.gov/ct2/show/NCT03661541

Share this post


Link to post
Share on other sites
Bigtime
On 1/22/2019 at 4:20 AM, VladimirM said:

You can buy SADBE (Squaric Acid Dibutyl Ester) now. Although not intended for HSV, it is essentially the same compound in essence. I bought it for my HSV. And he works great.

https://www.enbipharma.com/en/sadbeforte

I have bought some from this website aswell. It just arrived today. How do you use it? How much and how often? And where do you apply It?

Thanks

 

Share this post


Link to post
Share on other sites
VladimirM
11 hours ago, Bigtime said:

I have bought some from this website aswell. It just arrived today. How do you use it? How much and how often? And where do you apply It?

Thanks

 

I use it every 1.5 days. but I recommend you use it every 2-3 days.

It is possible that you will have more OB during this treatment than usual.

Note... that results can only be seen when you stop therapy for a week.

I apply SADBE to a part of the body where I usually have an OB and a tingling sensation. If it is a sensitive part of the body as a genitalia that can not be applied, then I apply to the closest possible part of body that it is not so sensitive part.

Probably one bottle will not be enough. For successful therapy it takes 4-8 bottles. The time for therapy lasts from 4-8 months if applied every 1-3 days.

It's likely that you will feel weaker than usual when you apply a solution. Understand the application is as a mini vaccination.

Respect the instruction manual.

Edited by VladimirM

Share this post


Link to post
Share on other sites
luckybell

I was a participant in the original study last year.  A patch was applied to my inner arm.  It was left in place for about 10 minutes and then removed.  This was done 3 times throughout the duration of the study. I can't remember the intervals - maybe every month. It was also a 2% solution.  It worked really well for me.  I had an outbreak about 1 week after the first patch application but then not again for about a year.  Now, I have had two outbreaks in two weeks so I feel desperate to try the vaccine again.  I don't think I would apply it anywhere other than the arm since that is where it was effective in the trials.

Share this post


Link to post
Share on other sites
VladimirM
2 hours ago, luckybell said:

I was a participant in the original study last year.  A patch was applied to my inner arm.  It was left in place for about 10 minutes and then removed.  This was done 3 times throughout the duration of the study. I can't remember the intervals - maybe every month. It was also a 2% solution.  It worked really well for me.  I had an outbreak about 1 week after the first patch application but then not again for about a year.  Now, I have had two outbreaks in two weeks so I feel desperate to try the vaccine again.  I don't think I would apply it anywhere other than the arm since that is where it was effective in the trials.

Maybe it was a placebo. Maybe you were in a placebo group. :)

Share this post


Link to post
Share on other sites
Tired of waiting

SquareX released this today, looks promising,

https://www.prnewswire.com/news-releases/squarex-announces-publication-of-clinical-results-for-sqx770-for-the-prevention-of-herpes-outbreaks-in-immunity-inflammation-and-disease-300795658.html

ST. PAUL, Minn., Feb. 14, 2019 /PRNewswire/ -- Squarex, a clinical-stage pharmaceutical company developing a topical immunomodulator for the long-term prevention of recurrent cold sores, today announced the publication of clinical data from a clinical trial of SQX770 in patients with frequent, infrequent, or zero herpes labialis (cold sore) outbreaks per year. The study, titled, "Immune characteristics correlating with HSV-1 immune control and effect of squaric acid dibutyl ester on immune characteristics of subjects with frequent herpes labialis episodes," by McTavish, Zerebiec, et al. has been published in the peer-reviewed journal Immunity, Inflammation and Disease.

The study characterized the immune-related gene expression levels in subjects with good versus poor control of HSV-1 infection (i.e., those with zero or few cold sore outbreaks compared to those with greater than six outbreaks per year) and found that good immune control of HSV-1 correlated with a particular immune-related gene signature.  Specifically, these patients exhibited higher expression of interferon-gamma (IFNG) and five other immune-related genes (P < 0.05 for each) and lower expression of interleukin 5 (IL5) and two other immune-related genes (P < 0.05 for each) in immune cells (peripheral blood mononuclear cells) stimulated with HSV-1 virus. Furthermore, it was found that a single topical application of squaric acid dibutyl ester (SADBE; Squarex's lead product candidate SQX770) changed the gene signature in subjects with frequent cold sore outbreaks to be more in line with that of subjects with fewer outbreaks, signaling an improved immune response to HSV-1. It also found that patients with good control of HSV-1 infection had higher immune cell proliferation in response to an HSV-1 challenge, and that SADBE treatment improved immune cell proliferation in subjects with poor control of HSV-1.

Founder and President of Squarex, Hugh McTavish, Ph.D., said, "As a frequent cold sore sufferer, I was desperate to find something that would help prevent outbreaks from reoccurring. Currently, there is no FDA-cleared treatment for delaying or preventing cold sore outbreaks. These results, which highlight the positive effect of SQX770 on immune control of HSV-1, combined with our placebo-controlled Phase 1/2 study that showed SQX770 is safe and effective and tripled the time to next cold sore outbreak, are highly encouraging.  We look forward to starting our pivotal trials and to sharing those results with the U.S. Food and Drug Administration."

About Squarex
Squarex is a clinical-stage pharmaceutical company developing a topical formulation of the immunomodulator squaric acid dibutyl ester (SQX770) for the prevention of recurrent cold sores (herpes labialis) and other infections caused by Herpes Simplex Viruses. Its Phase 1/2 placebo-controlled clinical trial showed the drug was safe and effective in preventing cold sore outbreaks, tripling the time to next cold sore outbreak from 40 days to more than 120. When FDA approved, SQX770 would be the first and only drug on the market to prevent cold sore outbreaks in the more than 2% of the U.S. population with greater than six outbreaks per year.

Contacts:

Tiberend Strategic Advisors, Inc. 
Brian Pinkston (Investors)
bpinkston@tiberend.com
(212) 375-6298

David Schemelia (Media) 
dschemelia@tiberend.com 
(212) 375-2686

SOURCE Squarex

 

 

Edited by Tired of waiting

Share this post


Link to post
Share on other sites
Bigtime
On 1/23/2019 at 11:54 AM, VladimirM said:

I use it every 1.5 days. but I recommend you use it every 2-3 days.

It is possible that you will have more OB during this treatment than usual.

Note... that results can only be seen when you stop therapy for a week.

I apply SADBE to a part of the body where I usually have an OB and a tingling sensation. If it is a sensitive part of the body as a genitalia that can not be applied, then I apply to the closest possible part of body that it is not so sensitive part.

Probably one bottle will not be enough. For successful therapy it takes 4-8 bottles. The time for therapy lasts from 4-8 months if applied every 1-3 days.

It's likely that you will feel weaker than usual when you apply a solution. Understand the application is as a mini vaccination.

Respect the instruction manual.

Vladimir, how did you come up with this treatment regime? Im asking because it seems very different from what they did in the study. Every few days versus a month + between treatments in the study.  Thanks a lot! 

Share this post


Link to post
Share on other sites
VladimirM
On 3/6/2019 at 5:17 PM, Bigtime said:

Vladimir, how did you come up with this treatment regime? Im asking because it seems very different from what they did in the study. Every few days versus a month + between treatments in the study.  Thanks a lot! 

Such treatment is used to treat HPV warts in children. 0.4% SADBE is applied every day.

Share this post


Link to post
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.


  • The Hive is Thriving!

    • Total Topics
      69,563
    • Total Posts
      468,604
  • Posts

    • viralfrog
      I would not be the first one, plenty of others here on the forum who get recurrent OBs despite heavy doses of antivirals. The blisters appear exactly in/around the spot where I had my first OB 4 years ago, plus all the symptoms I have are those commonly described as HSV-2 symptoms. In my opinion, it's a clear case.  But your suggestion is definitely an option that should not be ruled out. I'll wait until I get a bad enough OB again so I can go get another swab test. The outbreak needs to be bad enough to be able to break the blisters to get the liquid from inside right? I recall hearing something like this when I got tested years ago. The doctor used a swab that had tiny needles on it that would pop the blisters open. Do you know if this is right, i.e. you will not get a positive swab just from a mild OB / redness? 
    • jreemi
      90% elimination of the latent virus in thr ganglia probably will be a functional cure. Sure the small remaining amount can reactivate, but thete is a viral load threshhold for transmission. More than likely that won't be enough to cause transmission, or enough shedding for transmission. Damage enough of the latent virus and we are good to go. There is already a Crispr trial on humans going on right now https://newatlas.com/crispr-trial-underway-vertex-gene-therapy/58643/ So we are just waiting on Keith Jerome's lab and Excision Biotherapeutics to begin their trials. I've beem following Crispr for years now, and it keeps gettimg more accurate. I believe researchers at Duke have recently made a big breakthrough on accuracy, by changing the level of regulation instead of cutting DNA. I wonder if these labs collaborate with others such as Jerome's?
    • WilsoInAus
      No need to be tired at all, I'm sorry of you cannot accept the facts surrounding testing, but here they are. Your note is full of inaccuracies so let's iron those out. I don't need you to believe anything, I am just putting the facts out there. Here's a few studies: https://jcm.asm.org/content/37/5/1632 Here we have 29 patients with recent HSV-2 infection... 100% turned positive, 0% false negatives. https://jcm.asm.org/content/36/3/845/figures-only Here we have over 1,000 positive samples from people who have swabbed positive and compared to three different blood tests - over 95% accurate. https://jcm.asm.org/content/26/4/662?ijkey=9ebe349f98ed94f019ed788604c8fa19864a2c7e&keytype2=tf_ipsecsha Here we have 76 people who swabbed positive, the Westernblot detected 99% and an immunoblot 96%. Can you elaborate what is vague about these items of research. I'm sure now you'll want to review the references to these papers where you'll find even more. Some of them are in easy text for the beginner. So you stand corrected, it is in fact your comments that are spreading misinformation. That is not tolerated on this website. Also what nonsense that people do not get lesions to swab upon infection? Where did you read that? Hello Dolly? I'm afraid it is back to the books for you to do some more research before having such a rambunctious spew like above. STOP IT - we are all tired of your unsubstantiated drivel. This is 2019 we want something tangible, something real, something sound and wholesome and not drooling rants equal of the park bench antics of the drunks at 2am Sunday morning! I will NEVER stop because no matter how immature, how bombastic, how fantastic, how inaccurate, how frivolous, how false the spew that ends up on this website - the TRUTH will always be the light, the love, the guidance, the deliverance and the justice... no matter how many capitalised swear words are thrown!
    • Talx2520
      I took an IgG blood test 6 months after the episode. HSV-2 was negative (less than .91) and HSV-1 was high at 3.18
    • RainyDay2
      My comment was about THE BLOOD TEST!  You’re 95-100% accuracy for it?  Garbage.  Pure garbage.  You might as well have pulled that number out of your ass. Google search HIV accuracy... almost every medical site will tell you 4th generation HIV testing is as close to 99.9% percent you can possibly get after a certain period of elapsed time.  They will pretty much GUARANTEE you that you are indeed negative if you have a negative test. That defined certainty of accuracy WILL NOT AND CAN NOT be found for HSV blood tests.  You get vague descriptions of it’s accuracy from almost every site you visit.  NO CERTAINTIES.  Thousands of us on these forums KNOW the test isn’t accurate. When your score is between 1.1 and 3.5, this could be a false positive.  Certain sites list almost 1 in 2 tests can be false positives.  50 fucking percent!! And you want me to believe the test is 95-100% accurate? How come so many sites also seem to dance around the possibility of false negatives?   All that isn’t necessary in HIV testing.  Because if YOU DO get a low positive, the confirmatory HIV test checks for the actual VIRUS in your system.   And there are almost NO FALSE NEGATIVES.    NO HSV BLOOD TEST CAN DO THAT! Not even the Western Blot.  At the end of the day, it’s just a more detailed look at antibodies.  And many sites will tell you a “small” number of people may never develop. How small are we talking???? That can be any number.   Trash. And again, a large margin of people with herpes DO NOT GET LESIONS to be swabbed.  Google tells you that.  If majority of herpes infected have nothing to swab,  well that pretty much makes PCRs and cultures worthless for the most part doesn’t it?  If there is nothing to swab after a year, in your words, you are clear of herpes. BULLSHIT! So Wilso, just stop it.  You have never done scientific testing in a lab yourself on herpes. You are not a doctor.  You are constantly telling people false information.  Assuring them of promises you have no authority to make.  I’ve seen you do it time and time again.  Do you have regrets???????????  Im tired of your lies.  
×
×
  • Create New...

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.