Jump to content
World's Largest Herpes Support Group

Recommended Posts

lali

Does anyone have any updates on pritevilir's results? I can't find anything on the net. Is it still doing good? Last thing i saw was when it got fasttracked.

Share this post


Link to post
Share on other sites
MikeHerp

The trial is ongoing.  I believe it will be completed around september or octrober of this year.

Things are on track as far as I know.

 

EDIT:

https://clinicaltrials.gov/ct2/show/NCT03073967

Estimated Primary Completion Date : August 2019
Estimated Study Completion Date :

October 2019

 

This means, it is estimated that all data for all aspects of the trial, will be collected by Oct 2019 (all data related to the primary end point will be collected by August).  I'm not sure exactly by when the report would be published--perhaps a few months later? 

 

Edited by MikeHerp

Share this post


Link to post
Share on other sites
MikeHerp

By the way, I continue to have high hopes for this.  Unlkess something goes wrong, I think it might have a decent chance to get approved.

Share this post


Link to post
Share on other sites
Miss Horne
14 hours ago, MikeHerp said:

By the way, I continue to have high hopes for this.  Unlkess something goes wrong, I think it might have a decent chance to get approved.

I hope so, if this fails then I’m afraid I’ll be ingesting yellow jasmine (If you watch Outlander you’ll know what I’m on about). 

If you haven’t seen it then watch it, it’s about two hot people having loads of amazing sex in Scotland 200 years ago ;)

Apologies, I’ve gone slightly off subject here! 

Share this post


Link to post
Share on other sites
oneday

Would love for the damn dna to be shut down for good. Don't care if it stays there, just want to the bloody pest of a disease shut down. 

Share this post


Link to post
Share on other sites
Hopefloats30

Is it just something like a suppressant?

Share this post


Link to post
Share on other sites
Skrillah80
3 minutes ago, Hopefloats30 said:

Is it just something like a suppressant?

Yeahh pretty much.. Functional cure hopefully we get it in a couple years from now

Share this post


Link to post
Share on other sites
Hopefloats30
40 minutes ago, Skrillah80 said:

Yeahh pretty much.. Functional cure hopefully we get it in a couple years from now

Uggh a couple of years ...

Share this post


Link to post
Share on other sites
Skrillah80
1 minute ago, Hopefloats30 said:

Uggh a couple of years ...

Who knows.. It might be right around the corner.. 

Share this post


Link to post
Share on other sites
Miss Horne

We are waiting patiently for the data results to be published later on this year, about October time. 

If these are good we are hoping it doesn’t need to go to a phase 3 category and that it will be prescribed to immunocompromised patients, this could take another good couple of months. Depending on which county you live in, you could potentially get your hands on the drug then.

If it’s good to go on immuncompromised patients then perhaps trials can start on healthy folks, this is when we need to get together as a group and start making some noise with a petition. 

Share this post


Link to post
Share on other sites
123445
5 hours ago, Skrillah80 said:

Who knows.. It might be right around the corner.. 

Say everything goes accordingly does this mean it could be used for genital hsv1?

Share this post


Link to post
Share on other sites
Miss Horne
49 minutes ago, 123445 said:

Say everything goes accordingly does this mean it could be used for genital hsv1?

Yes, it will be a treatment for both strains, regardless of site of infection :)

Share this post


Link to post
Share on other sites
MikeHerp

Josh Bloom stated a few months ago that he thought pritelivir may be approved within 2 years.  He did note that he's going out on a limb with that prediction.

But it seems reasonable.  Earlier results suggested it's twice as effective as valtrex.  The only question is safety.  

Share this post


Link to post
Share on other sites
Skrillah80
41 minutes ago, MikeHerp said:

Josh Bloom stated a few months ago that he thought pritelivir may be approved within 2 years.  He did note that he's going out on a limb with that prediction.

But it seems reasonable.  Earlier results suggested it's twice as effective as valtrex.  The only question is safety.  

Soo when you thinking they gonna have this functional cure for the USA? 

Share this post


Link to post
Share on other sites
MikeHerp
1 hour ago, Skrillah80 said:

Soo when you thinking they gonna have this functional cure for the USA? 

It's being tested in the USA.  Because it's fast tracked, it could be approved based on the phase 2 results without needing phase 3.

Data will be collected by Oct this year.  I'm guessing it may take a few months to analyze and publish the results, so maybe end of this year or so.

Then, if those results show safety and efficacy (the main issue would probably be safety), then they submit an application for approval.  I'm not sure how long that takes, but maybe another 6-12 months?  

So yeah, altogether a bit less than 2 years.

But, it would be approved for immunocompromised.  Others would have to try to get it off label (I believe it may be possible).

And it wouldn't exactly be a functional cure.  Even with pritelivir, there was still shedding and outbreaks, though rarely.  Maybe combined with valtrex for some people it might approach a cure like effect (at least while you are taking it).  

Still, I'm guessing it would be a significant difference maker for many people.  

Edited by MikeHerp

Share this post


Link to post
Share on other sites
lali
On 2/3/2019 at 6:18 PM, MikeHerp said:

Josh Bloom stated a few months ago that he thought pritelivir may be approved within 2 years.  He did note that he's going out on a limb with that prediction.

But it seems reasonable.  Earlier results suggested it's twice as effective as valtrex.  The only question is safety.  

I was just about to say this. But since i didn't see anything new on the trial i was curious if anybody would of seen or hear anything. Not sure if it can go straight to the market without phase 3. I just hope they find a way to reduce the toxicity and it becomes available soon. The results just sounds so much better than valacyclovir. I'll take anything i can get to reduce transmission. 

Share this post


Link to post
Share on other sites
MikeHerp
3 hours ago, lali said:

I was just about to say this. But since i didn't see anything new on the trial i was curious if anybody would of seen or hear anything. Not sure if it can go straight to the market without phase 3. I just hope they find a way to reduce the toxicity and it becomes available soon. The results just sounds so much better than valacyclovir. I'll take anything i can get to reduce transmission. 

My understanding is that a drug CAN go to approval based on phase 2, if it has been fast tracked.  I've looked this up and I understand it is correct.  Pritelivir has been fast tracked.  That's why I believe Bloom claimed it could be approved within 2 years.

I think it could help, but keep in mind that it's only being tested in immunocompromised people.  Still, I think if it is approved, "healthy" people will be able to get their hands on it sooner or later.  I really believe that.  It will be out in the market.

 

 

 

Share this post


Link to post
Share on other sites
Miss Horne

Toxicity issues were reported but that was because they gave the poor individuals 70 times the recommended dose.

If you gave anybody 70 times the recommend dose of anything, paracetamol, ibuprofen, viagra etc whatever they’d suffer toxicity issues. 

Imagine the trials for viagra though, 70 times the recommend dose and a load of men with rock hard dicks for days on end! 

Edited by Miss Horne

Share this post


Link to post
Share on other sites
MikeHerp

I'd be interested in taking 70 doses of viagra.  

lol

Share this post


Link to post
Share on other sites
Miss Horne
3 hours ago, MikeHerp said:

I'd be interested in taking 70 doses of viagra.  

lol

I’d be interested in meeting up with you if you took 70 doses of viagra @MikeHerp ;)

Share this post


Link to post
Share on other sites
Miss Horne

Come to think of it, I think it was chimps they gave 70 doses to. 

Imagine that, a lab full of horny chimps for days, now my job doesn’t seem so bad! 

Share this post


Link to post
Share on other sites
JHenry
1 hour ago, Miss Horne said:

Only 30 participants? That seems low? 

 

The Indianapolis trial is dated Mid-November, 2018

Share this post


Link to post
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.


  • The Hive is Thriving!

    • Total Topics
      69,762
    • Total Posts
      470,503
  • Posts

    • win
      Hey hi202020, the Varivax vaccine definitely removed the neuralgia for me, at least so far (fingers crossed). My signs of HSV1 infection after the blood test came back positive in December (with a high IGG of over 55) were: horrible flu symptoms initially (in February) with swollen lymph nodes, followed by almost non-stop, super painful genital neuralgia, and one oral outbreak in March. However, the neuralgia has completely disappeared since the end of April (about a month or so). I had the first vaccine on April 10 and the booster shot on May 19, so about a week ago.
    • hi202020
      Hey Mackie I have the same neuralgia that you do, did you find anything that helped you? Did you try any vaccines? I’m feeling desperate as I’ve had non stop neuralgia/pain for 4+ months after contracting GHSV-1.
    • mconcerned1986
      Got my igG results after 13 months and it is negative I think I need to put this behind and may be rhink do some shitty infection that is causing this itching in genitals and on face. Just an FYI my Western blot at 7 months post exposure is negative.
    • Mikeike3
      Exactly. Plus some people don't seroconvert ever or for a long time, so it's even larger than that.  Also, it takes longer for hsv. To show up on wb than on a commercial igg test. 
    • Stolo868
      Even Terri says that sensitivity of WB for hsv1 is 95-96%. So somebody has to be in this 4-5%...
×
×
  • Create New...

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.