Jump to content
World's Largest Herpes Support Group

Recommended Posts

morty1234
2 minutes ago, blurneworder said:

I have daily pain where my left leg meets my groin. It won't go away.

Have you tried Amenamevir?

Share this post


Link to post
Share on other sites
WilsoInAus
1 hour ago, hi202020 said:

@blurneworder @morty1234

So sorry to hear this guys. 

I'm not sure whether to stay on the anti-virals or go off of them... seems like pros and cons. Anti virals help fight the virus but don't build up your immune system, and not being on anti-virals gives you immune system a chance to build up but potentially doesn't fight the virus as effectively and allows the virus to spread and cause more PHN

I hope you guys get better. 

Mine seems to have gotten better slightly over the 3.5 months I've had it. 

Mate, those guys do not have genital herpes.

Also not that PHN is a condition related to herpes zoster and is not associated with HSV 1/2. It refers to a specific attack on nerve fibres that HSV 1/2 do not cause.

Share this post


Link to post
Share on other sites
vzhe
18 hours ago, morty1234 said:

 

Great post! This is the kind of content I come here for! Thank you!

Share this post


Link to post
Share on other sites
JHenry

I dreamed last night Priteliver became market available within the next 18 months. Please tell me dreams do come true...  Henry

Share this post


Link to post
Share on other sites
dont quit!17
10 hours ago, JHenry said:

I dreamed last night Priteliver became market available within the next 18 months. Please tell me dreams do come true...  Henry

That would be nice to have as an option. 

Share this post


Link to post
Share on other sites
Mikeike3
On 5/17/2019 at 3:17 AM, WilsoInAus said:

Mate, those guys do not have genital herpes.

Also not that PHN is a condition related to herpes zoster and is not associated with HSV 1/2. It refers to a specific attack on nerve fibres that HSV 1/2 do not cause.

https://www.ncbi.nlm.nih.gov/pubmed/1624816

 

 

Share this post


Link to post
Share on other sites
WilsoInAus
7 minutes ago, Mikeike3 said:

Mate that's one article, from 1992, that asks the question as to whether HSV-1 can simulate PHN (note that the article is careful to point out that there was no clinical PHN).

It's a fair question to raise but there aren't enough cases to help narrow down the cause to HSV-1. Trigeminal neuralgia is a serious condition that impacts  a lot of people and herpes has not been implicated.

Share this post


Link to post
Share on other sites
Mikeike3
3 minutes ago, WilsoInAus said:

Mate that's one article, from 1992, that asks the question as to whether HSV-1 can simulate PHN (note that the article is careful to point out that there was no clinical PHN).

It's a fair question to raise but there aren't enough cases to help narrow down the cause to HSV-1. Trigeminal neuralgia is a serious condition that impacts  a lot of people and herpes has not been implicated.

Bill Halford who is top researcher for the HSV 2 vaccine agrees. He said this on his blog."Bill Halford December 4, 2013 at 10:30 pm #

Hi Corina,

I believe that the “constant prodrome symptoms” you describe are what I would consider a form of neuralgia; that is, (1) a sensation of pain, itching, or burning in the anogenital region that was infected with HSV-2, and (2) which is completely disproportionate to what you can see externally.

I am no neuroscientist, but my best guess is that this chronic neuralgia (chronic prodrome) is caused by inflammation in the sacral ganglia coming off the lower backbone. This is where latent HSV-2 lives….in neurons of the peripheral nervous system, and typically in the sacral ganglia coming off the lower segments of the backbone.

An important thing to remember is that the neurons that HSV-2 infects are sensory neurons. The primary cell body of these neurons is in the sacral ganglia, but they send long thin axons (like a fiber optic cable) out to the anogenital region of your body and into the spinal column (where the signals are relayed to your brain). When you are healthy, these sensory neurons only send signals (i.e., fire off like spark plugs) when there is a legitimate sensory input from the skin / epithelium in your anogenital region. A “legitimate input” that should cause neuron firing is touch, pressure, heat, pain, etc. I believe that in people with HSV-2, prodrome / neuralgia are what happen when cells of the immune system attack the infected neurons in the sacral ganglia. These attacks and inflammation in the ganglia cause the neurons to “misfire” in a way that is completely disproportionate to what is happening on the outside. Nonetheless, your brain tries to interpret these neuronal misfirings, and I believe that it interprets them as pain, itching, and burning that is disproportionate to what is happening on the surface. In many ways I believe that this is similar to the post-herpetic neuralgia that people experience after shingles, but is not nearly as intense and debilitating as what happens after shingles (i.e., a recurrence of VZV infection).

Not sure how much of that makes sense. The bottom line is that (1) constant prodrome symptoms probably means that your immune response is good enough to prevent HSV-2 reactivation events from causing recurrent lesions, a process that takes at least 5 days, but (2) your immune response is not good enough to immediately suppress HSV-2 reactivation events and the immune response that happens 3 or 4 days later drives inflammation in your sacral ganglia, and thus neuronal misfiring that tells your brain something itches or burns down there.

Please feel free to tell me which parts of this explanation don’t add up, as my explanation is based on 25% facts and 75% inference.

– Bill "

Share this post


Link to post
Share on other sites
blurneworder
3 minutes ago, Mikeike3 said:

Bill Halford who is top researcher for the HSV 2 vaccine agrees. He said this on his blog."Bill Halford December 4, 2013 at 10:30 pm #

Hi Corina,

I believe that the “constant prodrome symptoms” you describe are what I would consider a form of neuralgia; that is, (1) a sensation of pain, itching, or burning in the anogenital region that was infected with HSV-2, and (2) which is completely disproportionate to what you can see externally.

I am no neuroscientist, but my best guess is that this chronic neuralgia (chronic prodrome) is caused by inflammation in the sacral ganglia coming off the lower backbone. This is where latent HSV-2 lives….in neurons of the peripheral nervous system, and typically in the sacral ganglia coming off the lower segments of the backbone.

An important thing to remember is that the neurons that HSV-2 infects are sensory neurons. The primary cell body of these neurons is in the sacral ganglia, but they send long thin axons (like a fiber optic cable) out to the anogenital region of your body and into the spinal column (where the signals are relayed to your brain). When you are healthy, these sensory neurons only send signals (i.e., fire off like spark plugs) when there is a legitimate sensory input from the skin / epithelium in your anogenital region. A “legitimate input” that should cause neuron firing is touch, pressure, heat, pain, etc. I believe that in people with HSV-2, prodrome / neuralgia are what happen when cells of the immune system attack the infected neurons in the sacral ganglia. These attacks and inflammation in the ganglia cause the neurons to “misfire” in a way that is completely disproportionate to what is happening on the outside. Nonetheless, your brain tries to interpret these neuronal misfirings, and I believe that it interprets them as pain, itching, and burning that is disproportionate to what is happening on the surface. In many ways I believe that this is similar to the post-herpetic neuralgia that people experience after shingles, but is not nearly as intense and debilitating as what happens after shingles (i.e., a recurrence of VZV infection).

Not sure how much of that makes sense. The bottom line is that (1) constant prodrome symptoms probably means that your immune response is good enough to prevent HSV-2 reactivation events from causing recurrent lesions, a process that takes at least 5 days, but (2) your immune response is not good enough to immediately suppress HSV-2 reactivation events and the immune response that happens 3 or 4 days later drives inflammation in your sacral ganglia, and thus neuronal misfiring that tells your brain something itches or burns down there.

Please feel free to tell me which parts of this explanation don’t add up, as my explanation is based on 25% facts and 75% inference.

– Bill "

Mike, 

Do you think this applies to GHSV1 as well?

This could explain why I have the exact pains that his blog post is discussing.

Share this post


Link to post
Share on other sites
Mikeike3
1 minute ago, WilsoInAus said:

You have what? Do you have PHN?

Well, assuming it exists, yes I firmly believe I do.

Share this post


Link to post
Share on other sites
WilsoInAus
7 minutes ago, blurneworder said:

Mike, 

Do you think this applies to GHSV1 as well?

This could explain why I have the exact pains that his blog post is discussing.

But what evidence do you have of genital HSV-1? Most of these issues are caused by spinal issues. What investigations have you had on this possibility?

Note that there is no clinical support to Bill’s view which he freely admits.

Share this post


Link to post
Share on other sites
WilsoInAus
1 minute ago, Mikeike3 said:

Well, assuming it exists, yes I firmly believe I do.

You might, and it’s not relevant what is causing it, the treatment is the same. Please see a doctor to investigate spinal issues further.

Share this post


Link to post
Share on other sites
Mikeike3
1 minute ago, WilsoInAus said:

But what evidence do you have of genital HSV-1? Most of these issues are caused by spinal issues. What investigations have you had on this possibility?

Note that there is no clinical support to Bill’s view which he freely admits.

Indeed but I don't think it's outright dismissable or an outlandish claim, right?  Afterall, VZV and HSV1/2 are closest in DNA amongst all the hsv family strains.

Share this post


Link to post
Share on other sites
Mikeike3
Just now, WilsoInAus said:

You might, and it’s not relevant what is causing it, the treatment is the same. Please see a doctor to investigate spinal issues further.

 I am! I found a specialist an hour away from me!  Agreed, the diagnosis is irrelevant in terms of treating the symptoms, BUT it does matter if it's viral and I need to manage it to prevent or minimize the symptoms using antivirals. 

I have similar pain to those with diagnosed genital herpes have - random pain in my butt cheek that will last for 30-60sec, then random pain on my glans for 30-60, random itchiing there, random pain on my scrotum for 30-60s, background nerve pain in the glans/shaft area, etc. These things come and go, so either it is viral activity or some nerve damage. 

I think you've accepted I likely have HSV1, despite my 4-5 negative hsv1 pcr swabs and negative wb/igg's, because you admit my pictures look HSV1'ish.  Genital + oral symptoms began within 60 days of one another.

Share this post


Link to post
Share on other sites
blurneworder
Posted (edited)
26 minutes ago, Mikeike3 said:

 I am! I found a specialist an hour away from me!  Agreed, the diagnosis is irrelevant in terms of treating the symptoms, BUT it does matter if it's viral and I need to manage it to prevent or minimize the symptoms using antivirals. 

I have similar pain to those with diagnosed genital herpes have - random pain in my butt cheek that will last for 30-60sec, then random pain on my glans for 30-60, random itchiing there, random pain on my scrotum for 30-60s, background nerve pain in the glans/shaft area, etc. These things come and go, so either it is viral activity or some nerve damage. 

I think you've accepted I likely have HSV1, despite my 4-5 negative hsv1 pcr swabs and negative wb/igg's, because you admit my pictures look HSV1'ish.  Genital + oral symptoms began within 60 days of one another.

Mike,

My itching started on the scrotum after the skin turned red. This happened a few days after unprotected sex. I now have daily itching in my groin and anus. Taking a crap makes the anal itching even worse. I have daily tingling in the buttocks for a few seconds on and off.

I've been treated for bacterial and fungal infections, but to no avail. I've had my ass looked at by numerous specialists and nobody sees a damn thing.

HSV1 is the only culprit at this point. None of this happened until unprotected sex. I don't get why some folks have a hard time understanding my symptoms never existed until unprotected sex.

I've had bloodwork done by infectious disease, rheumatologist, and primary care doctors. All of my levels are normal and the only abnormal result is  HSV1 (twice, I might add).

It's not hard to see what's causing this.

The girl who did this to me stopped talking to me so I don't know her status at this point. My ex girlfriend doesn't care if I infected her, so she's not in a hurry to get tested.

Edited by blurneworder

Share this post


Link to post
Share on other sites
WilsoInAus
28 minutes ago, Mikeike3 said:

Indeed but I don't think it's outright dismissable or an outlandish claim, right?  Afterall, VZV and HSV1/2 are closest in DNA amongst all the hsv family strains.

No one has dismissed anything, It’s important that it is classified appropriately between fact and theory.

It is not possible to reach a factual diagnosis from reverse engineering a theoretical symptom.

There is no known common ancestor between HSV-1/2 and VZV. It is only a theory that they have one. If one exists then it existed more than 1 million years ago and maybe much more. This predates the physiology of man by quite a bit. 

Share this post


Link to post
Share on other sites
WilsoInAus

@blurneworder well we are all wondering how it is possible that a woman you had unprotected sex with tests negative AND transferred AND you had no lesions to swab.

So there are far more questions than answers surrounding culprits here.

Share this post


Link to post
Share on other sites
WilsoInAus

@Mikeike3 this is all about what you think. 

What one ought to think is clear.

Whether YOU think you have herpes, or whether YOU think you don’t - You’re right! 

But does it matter? What truly matters here?

Share this post


Link to post
Share on other sites
morty1234
Posted (edited)

 

Edited by morty1234

Share this post


Link to post
Share on other sites
blurneworder
5 hours ago, WilsoInAus said:

@blurneworder well we are all wondering how it is possible that a woman you had unprotected sex with tests negative AND transferred AND you had no lesions to swab.

So there are far more questions than answers surrounding culprits here.

And her current status is unknown. She could be like me and not get a positive results until months later

Share this post


Link to post
Share on other sites
WilsoInAus
43 minutes ago, blurneworder said:

And her current status is unknown. She could be like me and not get a positive results until months later

The chances of that, behind belief.

Mate you can grow! Leave the stigma, the punishment, the fear, the loss, the quagmire, the stench all behind. Reach for the love.

Fulfil your destiny!

Share this post


Link to post
Share on other sites
blurneworder
7 hours ago, WilsoInAus said:

The chances of that, behind belief.

Mate you can grow! Leave the stigma, the punishment, the fear, the loss, the quagmire, the stench all behind. Reach for the love.

Fulfil your destiny!

There is nobody else who gave me this virus.

it did not appear out of thin air.

Share this post


Link to post
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.


  • The Hive is Thriving!

    • Total Topics
      69,914
    • Total Posts
      471,913
  • Posts

    • Quest
      Right, that's why you spend every waking moment here because you have "PhD's and degrees" That's comical! If you're not messing with someone and hijacking a thread, you get the shakes!
    • MiLoBeng
      Yeah. I missed my old normal life too.
    • blurneworder
      Headaches and brain fog for me. It sucks i can’t eat grain or sugar anymore
    • MiLoBeng
      I wouldn't say HSV is totally harmless at all as it still poses risk for the women who's pregnant/in labor (despite of having antiviral to reduce the risk = it's never 100% risk-free either) + fatal disease to the babies (kiss of death lol..) + small % of people who are immunocompromised might be in danger because of the virus  Even though HSV doesn't kill us but it sure did create lots of inconvenience in our daily lives = Avoiding your favourite food (because of triggers) + disclosing issues in dating + mental stress (because it's incurable + stigma everywhr) + sex issues with loved one (scared of transmission) + dealing with OBs Most doctors (not all) out there only said it's harmless because it won't kill you (they couldn't care less of how you're going to deal or live with it) 🙂  *Some might even not saying anything at all (they just prescribe some med and sent you home) 😐
    • blurneworder
      Break free Wilsoanus! Accept you are wrong about diagnosing herpes.   theres a world out there for you to join and get a life! I noticed the flurry of new accounts making posts recently that you comment on before others. The original poster then praises you. Nice try creating fake profiles. You are a worse troll than Jay
×
×
  • Create New...

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.