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JaneyB

long-term use of valaciclovir

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JaneyB

Hi,

I suffer from frequent cold sores - about one outbreak a month. I won't get into details but I have tried many of the 'remedies' listed on this site to stop outbreaks, have had numerous testing done (including nutritional, etc.) and am otherwise healthy and fit. I started having cold sores as a teenager and now in my 40's, have always had frequent outbreaks, at least one every few months but as I age, it appears to be getting worse.

Anyway, I took prophylactic valtrex in my 20's and it didn't really work. I recently decided to give it another try and did 6 months of 500mg once daily valtrex. I didn't stop my outbreaks but they were less frequent and the biggest difference was that when I had an outbreak they were mostly very mild. Month one off the valtex and I had a mild outbreak, month two another mild outbreak and now month 3 I've had a significant outbreak, three separate sores and no apparent trigger. 

My doctor wanted me to only do 6 months due to the drugs potential impact on liver function. I tested liver function while on valtex and all good. Plus, no history here of liver function issues. I just think it's a general concern of his. 

Here's my question...seeing that it helped, I'm considering going back on valtex at 500mg/day to prevent outbreaks, at least for another 6 months. I don't like the idea of long-term use but I'm desperate. What are others' experience with long-term use? How long? Also, what is known about intermittent use - i.e. going on for 3 or 6 months, followed by a short 1 month break? I'm a little worried about becoming 'immune' to the drug, or having significant outbreaks once I cease use. I see there was an old thread regarding anti-virals decreasing the body's natural immune response but the data is old, limited and not reliable. 

Any insight or experience appreciated. 

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