Jump to content
World's Largest Herpes Support Group


  • Donate

    If Honeycomb has helped you, please help us by making a donation so we can provide you with even better features and services.

  • The Hive is Thriving!

    • Total Topics
      71,452
    • Total Posts
      483,915
  • 0_unsure-if-it-is-herpes.png

    Nervous about dating with herpes? Skip "the talk" and browse profiles here.

  • Posts

    • Voyager2
      Sure hope this pans out. 
    • Voyager2
      Don't forget there are two promising vaccines on the prophylactic front (but only pre-clinical): The Trivalent vaccine worked well on guinea pigs:  https://pubmed.ncbi.nlm.nih.gov/32347775/ The Einstein (Xvax) vaccine also has a ways to go: https://x-vax.com/ The fact HSV529 is in yet another clinical trial is good news for herpsters. 
    • Davrk8
      thank you for the info. I am uncircumcised. I applied some clotrimazole cream during the last outbreak I noticed, which seem to do the trick (around a month ago). But now, there new dots are appearing at a different location on the glans. Wasnt sure if balanitis can come back so soon or if it could be something else. 
    • Josse
      Looks like mild balanitis. If you are uncircumcised then thats normal every now and then due to accumulation of yeast and the irritation of the foreskin
    • MikeHerp
      I think the simple reason is that this is a fund raiser that was started by our community rather than by Fred Hutch.  Or rather, FHC started it in response to our request.   I still think they should somehow feature it in their pages.  But anyway, that's just how they do it. Keep in mind that FHC's main focus is curing cancer.  It's a cancer research institute.  They might feel that putting stuff on their website that isn't directly related to cancer might give people the impression, especially cancer cure donors (who are by far the main donors to FHC), that FHC is losing its focus. So we have to work within these limits.   However, I do draw strength from the fact that FHC has tried to help us with the fund raiser.  Among others: 1.  When the new research paper is released, FHC has gotten an agreement with a prominent sexual health blogger, to promote the research and the fund raiser. 2.  There is another potential promotion in the works that might get back on track if the US is able to get the coronavirus under control. So FHC has actively helped us to promote the fund raiser.
Sign in to follow this  
Tired of waiting

HSV Vs Chicken Pox/shingles

Recommended Posts

Tired of waiting

Can any one point me to some literature that might explain the difference between HSV and Chickenpox/Shingle? The viruses enter the body the same way, become latent in the same nerve location and have other similarities.   I'm trying to understand what is different about HSV that is preventing a vaccine from being created like was done for Shingles?

Thanks

Share this post


Link to post
Share on other sites
WilsoInAus
43 minutes ago, Tired of waiting said:

Can any one point me to some literature that might explain the difference between HSV and Chickenpox/Shingle? The viruses enter the body the same way, become latent in the same nerve location and have other similarities.   I'm trying to understand what is different about HSV that is preventing a vaccine from being created like was done for Shingles?

Thanks

I think the first thing to appreciate is that a shingles vaccine is not actually all that great, it reduces the chance of a shingles occurrence by less than 50% and so on. I feel the reason why this vaccine is 'viable' is because the consequences of nerve damage are significant.

Because antivirals already reduce symptoms and shedding etc. by 50% or more, a vaccine has to exceed this to be 'viable' in a HSV-1, HSV-2 context.

Share this post


Link to post
Share on other sites
Tired of waiting

The shingrex vaccine is being advertised at being 90% effective.  I do not have the chickenpox  effectiveness numbers I would assume that is also equal high or they would not give to children. 

Regardless of the shingle vaccine, I'm trying to find out what the technical difficulties in developing a vaccine for HSV when it is so similar to chickenpox virus? 

Share this post


Link to post
Share on other sites
WilsoInAus
1 hour ago, Tired of waiting said:

The shingrex vaccine is being advertised at being 90% effective.  I do not have the chickenpox  effectiveness numbers I would assume that is also equal high or they would not give to children. 

Regardless of the shingle vaccine, I'm trying to find out what the technical difficulties in developing a vaccine for HSV when it is so similar to chickenpox virus? 

Shingrix does show a lot more promise than older vaccines I grant you that. Early days but signs are good it will be quite effective.

Remember that the viruses do not share much DNA at all. Although there are some aspect of the behaviour of the virus that appear highly similar, they share very little similarities in DNA. The 'herpes' family are only vaguely related.

I am sure there are all sorts of theories as to why vaccines are harder to develop or similar vaccine approaches are less effective for HSV 1/2. They seem to have at their core that HSV 1/2 are more evolved in terms of residing inside nerve cells and moving cell-to-cell avoiding the immune system. HSV 1/2 does not expose itself as much as other viruses and doesn't seek to achieve as much as other viruses.

Share this post


Link to post
Share on other sites
Schweppes

Tried the Varivax vaccine. Incredibly good improvement by removal of prodrome back pain. Frequency, duration, and severity of outbreaks.... only slight improvement and that could just be optimism. I think it was WELL worth it, but it was just not as much improvement as I had hoped. The removal of the constant prodrome back pain more than justified the 180$ (Price of vaccine) at Wal-greens.

There is a definite relation. The biggest contributor to failure I see in people that try Varivax is that they take antivirals, immediately before and within 30 days of vaccination. It’s a live vaccine... if you kill it with antivirals it becomes worthless and no immune response is generated. 

Share this post


Link to post
Share on other sites

Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Reply to this topic...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Sign in to follow this  

×
×
  • Create New...

Important Information

We have placed cookies on your device to help make this website better. You can adjust your cookie settings, otherwise we'll assume you're okay to continue.