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Tacotime

HSV, Nuerodegeneration, Cognitive Dysfunction & other Associated Morbidities

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Tacotime
Posted (edited)

Research over the last few years tying herpes viruses to nuero degeneration among other chronic diseases it triggers is why we need to find a cure.  

From the study “Ezzat and his colleagues found that #HSV-1 is able to accelerate the transformation of soluble #amyloid proteins into thread-like structures that constitute the amyloid plaques”:

In animal models of Alzheimer’s disease, they saw that mice developed the disease within 48 hours of infection in the brain. In absence of an HSV-1 infection, the process normally takes several months.

 

Edited by Tacotime

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Tacotime

My thoughts are if we can cure Herpes infections or prevent them all together we may be able to reduce the burden of neurodegenerative diseases as the studies above clearly indicate they’re playing a causal role in the disease process.

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WilsoInAus

Well that doesn’t explain the fact that about 5% of people with HSV-1 develop AZ and the same proportion of people who do not have HSV-1 also do.

It further doesn’t explain why 90% of people with Down syndrome develop AZ.

Have a look at the work of John Hardy.

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Tacotime

HSV has been found not only to drive Alzheimer’s but also a variety of other types of neurodegenerative diseases some of which include Parkinson’s and Lewy body dementia.

 

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Tacotime
Posted (edited)

This thread is about HSV and it’s implications in regard to the wide spectrum of neurodegenerative diseases, and thus why a cure is desperately needed.

Edited by Tacotime

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T9000

It's too bad they weren't doing this kind of research 30 years ago instead of the crotchety old idiots at the NIH refusing funding to scientists studying HSV-1 on the grounds that HSV-1 can't be implicated in alzheimer's since "most people have HSV-1 but most people don't develop alzheimer's." You'd think people with PhDs in neuroscience could conceive of the idea that maybe pathogens aren't necessarily causative, but could still be contributive, especially since they were already shooting in the dark with it. Now it's almost 2020 and alzheimer's drugs are basically nonexistent.

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WilsoInAus
1 hour ago, Tacotime said:

HSV has been found not only to drive Alzheimer’s but also a variety of other types of neurodegenerative diseases some of which include Parkinson’s and Lewy body dementia.

 

This is not true at all, it’s all correlative awaiting further research. 

This is just another of your rants to spread fear and misinformation.

Please publish some papers that are causative.

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WilsoInAus
48 minutes ago, T9000 said:

It's too bad they weren't doing this kind of research 30 years ago instead of the crotchety old idiots at the NIH refusing funding to scientists studying HSV-1 on the grounds that HSV-1 can't be implicated in alzheimer's since "most people have HSV-1 but most people don't develop alzheimer's." You'd think people with PhDs in neuroscience could conceive of the idea that maybe pathogens aren't necessarily causative, but could still be contributive, especially since they were already shooting in the dark with it. Now it's almost 2020 and alzheimer's drugs are basically nonexistent.

But that’s because pathogen theory has failed each time, they’ve been looking at the wrongness things.

Please are the work of John Hardy and you’ll see that the only likely success is addressing the amyloid process.

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Tacotime
1 hour ago, WilsoInAus said:

But that’s because pathogen theory has failed each time, they’ve been looking at the wrongness things.

Please are the work of John Hardy and you’ll see that the only likely success is addressing the amyloid process.

 

1 hour ago, WilsoInAus said:

This is not true at all, it’s all correlative awaiting further research. 

This is just another of your rants to spread fear and misinformation.

Please publish some papers that are causative.

You are 100% wrong the pathogen theory is most promising area in research today. Wake up mate.

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Tacotime

Someone with half a brain can easily connect the dots but as usual you are in denial.

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WilsoInAus
1 minute ago, Tacotime said:

Someone with half a brain can easily connect the dots but as usual you are in denial.

Those with a full brain have moved on and are working on the amyloid process. See the work of John Hardy.

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Tacotime
1 hour ago, WilsoInAus said:

Please are the work of John Hardy and you’ll see that the only likely success is addressing the amyloid process.

Amyloid beta is an anti microbial peptide that is part of the innate immune response and it functions by encapsulating infectious agents such as Herpes Simplex Virus. 

Of course at the cost of cognitive function and ultimately nuerodegeneration.

Addressing it means preventing the infection in the first place or curing it.

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Tacotime
2 minutes ago, WilsoInAus said:

Those with a full brain have moved on and are working on the amyloid process. See the work of John Hardy.

😂 you’re not the brightest tool in the shed are you? Amyloid beta is an antimicrobial peptide.

You really are very uninformed on the subject I suggest you do more research as opposed to wasting time bullying and arguing with people on this board.

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Tacotime

https://www.the-scientist.com/news-opinion/herpes-viruses-implicated-in-alzheimer-s-disease-64246

 

A new study shows that the brains of Alzheimer’s disease patients have a greater viral load, while another study in mice shows infection leads to amyloid-β build up.

 

In the other study, available as a preprint on the Cell website and in Neuron July 11, Rudolph Tanzi and Robert Moir, both researchers at Harvard Medical School and Massachusetts General Hospital, and their colleagues tested how amyloid-β in the brain—which these labs previously found to be an antimicrobial—reacts to herpes simplex virus 1 (HSV1), HHV6A, and HHV6B. These strains all tend to integrate into the genomes of neurons. They found that in a culture of human neuronal cells, amyloid-β could prevent HSV1 infection and can bind and aggregate the HSV1 and HHV6 viruses. Mice infected with HSV1—which can cause encephalitis—that also had genetically elevated amyloid-β expression were protected against encephalitis, but also had increased amyloid deposits. 

 

 
 

These studies further add to the steadily increasing number of papers that support a microbial role in Alzheimer’s disease,” Ruth Itzhaki, a molecular neurobiologist at the University of Manchester in the U.K. who studies the link between viruses and the development of Alzheimer’s disease, writes in an email to The Scientist. 

A recent epidemiology study adds real-world credence to the microbial link to Alzheimer’s. A population study in Taiwan examined more than 33,000 individuals and found that those with a herpes simplex virus infection had a 2.5-fold greater risk of developing Alzheimer’s disease. The study authors found that in those people treated with antiherpes medications, the 2.5-fold risk dropped back down to baseline. 

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Tacotime

For the sake of science and truth please disregard forum troll/con man Wilson.

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WilsoInAus

Yes that’s about 20’years old and has gone nowhere. Yes many pathogens get in the plaques. Hypothesis that this is a good thing or bad thing or unproven. Researchers agree given up on HSV-1 being causative and are now arguing (unsuccessfully) that perhaps it accelerates the AZ process.

Just now, Tacotime said:

For the sake of science and truth please disregard forum troll/con man Wilson.

This is your response to anyone who disagrees with you and points out the true science.

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Tacotime
Posted (edited)

Are you blind? Take a closer look I just provided evidence you choose to ignore. I post your ban thread to show what a moron and pathetic loser you are and how you literally detract from anything productive or science related.

 

The article and research is from 2018/2019 herpes is one of the hottest topics in the field of nuerodegenration today.

https://www.the-scientist.com/news-opinion/herpes-viruses-implicated-in-alzheimer-s-disease-64246

 

Read carefully before responding you blind bat.

Edited by Tacotime

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WilsoInAus
46 minutes ago, Tacotime said:

Amyloid beta is an anti microbial peptide that is part of the innate immune response and it functions by encapsulating infectious agents such as Herpes Simplex Virus. 

Of course at the cost of cognitive function and ultimately nuerodegeneration.

Addressing it means preventing the infection in the first place or curing it.

No that isn’t known. That Alzheimer’s changes the immune response seems to be the issue.

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Tacotime
Posted (edited)

 

Pathogen theory and the microbiome is the hottest area in research today. Look into it you might surprise yourself!

 

NEW RESEARCH: HERPES MAY MAKE YOU GET ALZHEIMER’S EARLIER

https://www.beingpatient.com/herpes-accelerates-amyloid-alzheimers/

https://futurism.com/the-byte/herpes-virus-alzheimers-disease

https://www.forbes.com/sites/robinseatonjefferson/2018/07/25/evidence-mounts-that-germs-may-cause-alzheimers/#107f5f304fc9

Edited by Tacotime

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Tacotime
Posted (edited)
8 minutes ago, WilsoInAus said:

No that isn’t known. That Alzheimer’s changes the immune response seems to be the issue.

Amyloid beta is an antimicrobial peptide is 100% a fact

You’re an adult it’s time to start acting like one! You can do it I know it’s challenging with all the mental health issues you mentioned to me you’re struggling with. I’m sorry you have problems with your self image and abuse from your childhood but taking your anger out on this forum is not the place!

Be strong little cherry picking willy, you can do it!

Edited by Tacotime

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WilsoInAus

No I’m sorry @Tacotime it is clear that it is you that knows very little about AZ.

I have seen all those papers you link, they are no surprise nor look that hard at causation.

I will put together a compendium of the latest research that will give a taste of the broader issues in unlocking the keys to AZ.

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Tacotime

No I’m sorry little willy you are clearly in denial 😂🤦‍♂️ 

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Tacotime

In the end it will be microbes—bacteria, viruses and fungus—found to be at the root of all disease and aging, and specifically Alzheimer’s, contends geneticist Dr. Rudolph “Rudy” Emile Tanzi.

“The two biggest threats to healthy aging have had to do with dealing with infection,” said Tanzi, who specializes in Alzheimer’s and the brain at Massachusetts General Hospital (MGH) and Harvard Medical School.  “Think about it. When we increased the lifespan from 35 to 50, it was by covering the sewers. When we increased the lifespan from 50 to 75, it was with the use of antibiotics. Now we are looking for viruses in all of the major life-threatening diseases of our time—Alzheimer’s, cancer, Parkinson’s—and guess what? Infection is now cropping up in all of them.”

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Tacotime
Posted (edited)

Take that compendium and shove it up your bum. This thread is about raising awareness not the doubt you constantly cast about the danger of this virus.

Edited by Tacotime

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