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JHenry

In anticipation of something to celebrate!

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JHenry

While there has been bits and pieces of encouraging news,.....  yet in other respects it seems it’s been a while since something REALLY noteworthy and energizing has been shared.   Which gives me pause to think, you know what?  I’ve optimistic that soon, we are all going to be on the receiving end of something very disrupting of the status quo.  With Thrivent moving over to Merck (I think) and Einstein College of Medicine partnering and creating X-Vax means these folks are very, VERY serious!  Hopefully, in the not terrible distance, we may have something to raise a glass to!    Hang in there, the Calvary is still riding!!!  

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hunger4more
Posted (edited)

Everytime I have an ob I optimistically hope it's my last one.... 😩

Edited by hunger4more

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SeanHanson
1 hour ago, JHenry said:

While there has been bits and pieces of encouraging news,.....  yet in other respects it seems it’s been a while since something REALLY noteworthy and energizing has been shared.   Which gives me pause to think, you know what?  I’ve optimistic that soon, we are all going to be on the receiving end of something very disrupting of the status quo.  With Thrivent moving over to Merck (I think) and Einstein College of Medicine partnering and creating X-Vax means these folks are very, VERY serious!  Hopefully, in the not terrible distance, we may have something to raise a glass to!    Hang in there, the Calvary is still riding!!!  

Fingers crossed!! Could you elaborate a bit on the research or maybe post a link to it? Definitely could be a little light in the dark 🙂

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JHenry

Read what I wrote and start Googling.  Both the Einstein College of Medicine (William Jacobs and Betsy Herold)  and University of Pennsylvania/Trivalent (Harvey Friedman) seem to believe they are on the right track and have established relationships outside of their respective universities.  Yes, it’s early, but they are taking the bat and readying to swing at HSV.   Cross those fingers and stay positive!  

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IAmDesperate
Posted (edited)
20 minutes ago, JHenry said:

Read what I wrote and start Googling.  Both the Einstein College of Medicine (William Jacobs and Betsy Herold)  and University of Pennsylvania/Trivalent (Harvey Friedman) seem to believe they are on the right track and have established relationships outside of their respective universities.  Yes, it’s early, but they are taking the bat and readying to swing at HSV.   Cross those fingers and stay positive!  

Hi, is this for both HSV1&2? And please link the article if you can find it again cuz I couldn't find the right one :/ thank you very much and how soon do you think this would be on the market?

Edited by IAmDesperate

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JHenry

They are just getting started, but seem confident and seem to have the wind at their backs, BUT—-just getting started is the is huge.

 

 https://x-vax.com/   This is who Einstein College of Medicine, Jacobs/Herold have partnered with.

If I understand correctly, University of Pennsylvania and their candidate, Thrivalent (Now G103 I believe, was partnered with Immune Design, who has now partnered with Merck. There are others on this forum much more informed and eloquent in discussing any and all of this, perhaps they can explain it further:

https://www.genengnews.com/news/merck-to-acquire-immune-design-for-300m-boosting-immunotherapy-vaccine-pipeline/

It’s very early, preclinical, but nonetheless, sounds like there is reason to have optimism. 

There are others, Square-X and also Phylogica.com with their peptide vaccine.  All early, but it has to start somewhere.

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IAmDesperate
19 minutes ago, JHenry said:

They are just getting started, but seem confident and seem to have the wind at their backs, BUT—-just getting started is the is huge.

 

 https://x-vax.com/   This is who Einstein College of Medicine, Jacobs/Herold have partnered with.

If I understand correctly, University of Pennsylvania and their candidate, Thrivalent (Now G103 I believe, was partnered with Immune Design, who has now partnered with Merck. There are others on this forum much more informed and eloquent in discussing any and all of this, perhaps they can explain it further:

https://www.genengnews.com/news/merck-to-acquire-immune-design-for-300m-boosting-immunotherapy-vaccine-pipeline/

It’s very early, preclinical, but nonetheless, sounds like there is reason to have optimism. 

There are others, Square-X and also Phylogica.com with their peptide vaccine.  All early, but it has to start somewhere.

Ahh thank you for the link, but sadly I have HSV1 :(

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hunger4more

Sounds like X-vaxs' biggest concern is prevention and erradication secondary..... 🤦🏻‍♂️

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T9000
1 hour ago, hunger4more said:

Sounds like X-vaxs' biggest concern is prevention and erradication secondary..... 🤦🏻‍♂️

Well yeah they've created a vaccine, not a curative therapy. 

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Moibalushi
2 hours ago, T9000 said:

Well yeah they've created a vaccine, not a curative therapy. 

It would really be amazing if they created a preventative one.

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MiLoBeng
Posted (edited)
9 hours ago, IAmDesperate said:

Hi, is this for both HSV1&2? And please link the article if you can find it again cuz I couldn't find the right one :/ thank you very much and how soon do you think this would be on the market?

I'm pretty sure they're aiming to prevent both HSV-1/2. It's well written on X-VAX official website. Bad news is they're still in preclinical phase and it'll probably take another 8-10 years to be in the market.

Edited by MiLoBeng

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MiLoBeng
17 hours ago, hunger4more said:

Sounds like X-vaxs' biggest concern is prevention and erradication secondary..... 🤦🏻‍♂️

Currently our only hope of functional cure lies in gene-editing (Dr Keith Jerome-FHC) 

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hunger4more
Posted (edited)
2 hours ago, MiLoBeng said:

Currently our only hope of functional cure lies in gene-editing (Dr Keith Jerome-FHC) 

Im hoping something "accidental" comes along faster....

Also Im very confused about this herpes culture... science says its millions of years old and yet fast forward to 2019 and we still cant get rid of it? I honestly call bullshit. I'm extremely curious to know how the ancients or indigenous peoples deal with it. Now I'm aware that not all indigenous tribal peoples may be conflicted by it but then wheres this million year trail? Its been strictly isilated to the developed world?

I wouldnt be surprised at all if the peoples of the Amazon have a way of getting rid of this thing. In fact they may have erradicated such ailments from their civilizations for millenia. The Amazon is and has been extremely overlooked, under-studied and not much is known about their history still today.

Yet with recent deforestation programs they have been discovering that under the tropical carpets of the Amazon, civilizations that consisted of millions of people once thrived in what was previously believed to be un-inhabitable terrain.

Curare came from the peoples of the Amazon.... they are specialists in Amazonian plant medicine.... 🤔

Something is fishy and I don't trust western medicine or the instutions behind them.... 

Edited by hunger4more

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IAmDesperate
53 minutes ago, hunger4more said:

Im hoping something "accidental" comes along faster....

Also Im very confused about this herpes culture... science says its millions of years old and yet fast forward to 2019 and we still cant get rid of it? I honestly call bullshit. I'm extremely curious to know how the ancients or indigenous peoples deal with it. Now I'm aware that not all indigenous tribal peoples may be conflicted by it but then wheres this million year trail? Its been strictly isilated to the developed world?

I wouldnt be surprised at all if the peoples of the Amazon have a way of getting rid of this thing. In fact they may have erradicated such ailments from their civilizations for millenia. The Amazon is and has been extremely overlooked, under-studied and not much is known about their history still today.

Yet with recent deforestation programs they have been discovering that under the tropical carpets of the Amazon, civilizations that consisted of millions of people once thrived in what was previously believed to be un-inhabitable terrain.

Curare came from the peoples of the Amazon.... they are specialists in Amazonian plant medicine.... 🤔

Something is fishy and I don't trust western medicine or the instutions behind them.... 

I know right? I'm expecting for a "miracle" too and I hope it happens since we don't deserve this. I really want to believe that there is another way to get rid of hsv virus but unfortunately, there is none :( since the scientists already published that the latent virus (which is the mofo, sorry for my language, that causes all of this) lives in our nervous system and I don't think herbal treatment can reach up there. Immune system can't attack nervous system. We could train it to do so but the volunteers might die while testing and they don't want it. I feel like we should trust science this time :( and the tribal people probably just live without knowing what it is like enduring the pains and all, just like South East Asians have no education about hsv and they think it's just skin infection and there is no need to go to doctors.

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hunger4more
Posted (edited)
2 hours ago, IAmDesperate said:

I know right? I'm expecting for a "miracle" too and I hope it happens since we don't deserve this. I really want to believe that there is another way to get rid of hsv virus but unfortunately, there is none :( since the scientists already published that the latent virus (which is the mofo, sorry for my language, that causes all of this) lives in our nervous system and I don't think herbal treatment can reach up there. Immune system can't attack nervous system. We could train it to do so but the volunteers might die while testing and they don't want it. I feel like we should trust science this time :( and the tribal people probably just live without knowing what it is like enduring the pains and all, just like South East Asians have no education about hsv and they think it's just skin infection and there is no need to go to doctors.

We havent cured things not because we can't its because profits are a bigger priority. Trust me when I say I know it sounds like conspiracy talk but look at where and what they throw money at.... sickness is lucrative. So is death (War) The military budget is criminal to say the least, as is Nasa's budget That's just simple math, then look at all the obscene hurdles set in place to help deter anyone from going the distance. They only cry ethics when it comes to anything that could potentially benefit the greater good.

Edited by hunger4more

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Quest

I will raise my glass now to the future!

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IAmDesperate
10 hours ago, hunger4more said:

We havent cured things not because we can't its because profits are a bigger priority. Trust me when I say I know it sounds like conspiracy talk but look at where and what they throw money at.... sickness is lucrative. So is death (War) The military budget is criminal to say the least, as is Nasa's budget That's just simple math, then look at all the obscene hurdles set in place to help deter anyone from going the distance. They only cry ethics when it comes to anything that could potentially benefit the greater good.

Yeah... sometimes I think like that too you know. Like they try to get money from us while postponing the cure, maybe they already have it but they decide it’s not the time to release yet or something like that. But it does sound like conspiracy so idk what to believe in and I hope it’s not the true cuz I want the cure, we all want the cure and I don’t want to experience the stigma of it anymore. It’s devastating... 

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hunger4more
Posted (edited)
43 minutes ago, IAmDesperate said:

Yeah... sometimes I think like that too you know. Like they try to get money from us while postponing the cure, maybe they already have it but they decide it’s not the time to release yet or something like that. But it does sound like conspiracy so idk what to believe in and I hope it’s not the true cuz I want the cure, we all want the cure and I don’t want to experience the stigma of it anymore. It’s devastating... 

Its extremely devasting, not only the stigma but the reality. At 35 I don't have kids or a relationship, I'd like to pursue these things but I no longer look at any potential partners with the same enthusiasm, rather, what could have been. Same with my career... My ambition is in the gutters, when I have an ob on my lip I wanna hide, dont want to go to work, and get extremely moody and cold towards people... Its extremely difficult to look your best when you don't feel your best during an episode...

I generally avoid making long drawn out plans etc....

I also spend too much time reminiscing about the psychological freedom and enthusiasm I once had before being gifted this plague.

Edited by hunger4more

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iFdUp
On 6/25/2019 at 2:51 PM, MiLoBeng said:

Currently our only hope of functional cure lies in gene-editing (Dr Keith Jerome-FHC) 

Excision bio. is working on a cure as well. 

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IAmDesperate

Okay, guys. I think we really should anticipate something. Dr. Jerome said they wanted to enter the trials in the not-too-distant-future so it seems like they wouldn’t be able to do so anytime soon. He needs to find out if there are any mutations and increase the percentage from 50-90% to 100% in order to completely eradicate the virus which is hopeful cuz there was no mutation whatsoever when he tested on mice. I absolutely appreciate it and please don’t forget to donate to his research! However, on ExcisionBio showed that CRISPR would enter trials for HSV1&2 in 2021 and the protein is saCas9 for HSV1 and CasY for HSV2 (on ExcisionBio pipeline). They had a problem in the past due to Cas9 being too big to enter nervous system to kill virus cuz it was originally designed for HIV. But they discovered new protein Cas3 and Cas12 with gold nanoparticle so I think they can crush the latent virus and AAV is not a problem for them. They would just need to control the length of the DNA to cut which I hope is not as difficult as AAV and making protein. If there is no mutation and then can control the dna length to cut then I think it’s possible to have a cure in the next 5 years. If Dr. Jerome has collaborated with CRISPR (maybe with China too) then maybe we would have it sooner. Please feel free to correct at any place if you think I’m wrong. I strongly believe that the cure is gonna be here soon. 

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IAmDesperate
Posted (edited)
14 minutes ago, iFdUp said:

Excision bio. is working on a cure as well. 

Dr. Jerome and ExcisionBio should have worked together for like an ultimate cure cuz it would speed up the process and if ExcisionBio can cure it first (unless they enter the trials before ExcisionBio but that’s impossible) then Dr. Jerome’s research would have no use right? 🤔

Edited by IAmDesperate

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T9000
7 hours ago, hunger4more said:

Its extremely devasting, not only the stigma but the reality. At 35 I don't have kids or a relationship, I'd like to pursue these things but I no longer look at any potential partners with the same enthusiasm, rather, what could have been. Same with my career... My ambition is in the gutters, when I have an ob on my lip I wanna hide, dont want to go to work, and get extremely moody and cold towards people... Its extremely difficult to look your best when you don't feel your best during an episode...

I generally avoid making long drawn out plans etc....

I also spend too much time reminiscing about the psychological freedom and enthusiasm I once had before being gifted this plague.

At what age did you get it?

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iFdUp
5 minutes ago, IAmDesperate said:

Dr. Jerome and ExcisionBio should have worked together for like an ultimate cure cuz it would speed up the process and if ExcisionBio can cure it first (unless they enter the trials before ExcisionBio but that’s impossible) then Dr. Jerome’s research would have no use right? 🤔

The methods being used by both teams are different. Dr Jerome uses endonuclease editing and excision is exploring crispr cas editing. 

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IAmDesperate
Posted (edited)
3 minutes ago, iFdUp said:

The methods being used by both teams are different. Dr Jerome uses endonuclease editing and excision is exploring crispr cas editing. 

Yeah I know that they are different but once ExcisionBio succeeds, hsv is cured. Would it still be useful if you try to cure something that is already cured? I don’t think so. That’s why I’m curious about why they don’t work together to figure out the problems with they’re having.

Edited by IAmDesperate

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hunger4more
8 minutes ago, T9000 said:

At what age did you get it?

25

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