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    • Cas9
      @Ohsotired It took 10 years for mouse studies? Not sure if that's true, but anyway, it takes a while when starting out because you're kind of starting from scratch. That also involves in vitro work. Then you need to go to mice. So the in vitro and mice work is where a lot of the figuring out has taken place. It involved a lot of painstaking work. In fact Dr. Jerome started with an old style editor (CRISPR hadn't been invented yet). When he wasn't getting the results with whatever editor he was using, and CRISPR was invented, he then switched to CRISPR. He got worse results with that. His team then figured out what the issues were, step by step. And finally we are where we are; i.e. 90% and 50% cleavage in SCG and TG. And he knows what the issue is regarding improving those percentages to 90%+ in the DRG and TG. So a lot of the figuring out took a while and now we just need to see that it works in guinea pigs and then primates. Unless something goes wrong, and there's no reason to believe that it will, we are not going to take 10 years for each animal of course. If things go smoothly I would say 3 or 4 years. Then on to clinical. But we'll see. " Most researchers spend 3-6 years in the preclinical stage of research, 3-7 years in the clinical phase, and 2-5 years afterwards to launch the drug for public use. That’s Titans about 18 years in all for a drug to make it to mainstream. " So you chose the high end for each range. If I choose the low end for each it's 8 years. It's really impossible to predict. But I think the majority of us think that if it's successful it's at least 10 years away. Before your research, how long did you think the process would take? If it takes 10 years, how old will you be?
    • hk81
      The funding from NIH for the lab tests on mice will end in 2023, so this can give an idea on the timeline. https://grantome.com/grant/NIH/R01-AI132599-01A1 When the tests are moved to bigger animals (guinea pig and monkey), the possibility of experimentation is lower due to higher costs. The tests on monkeys are done only when the research has reached some solid results and only a few combinations are tested (see for example the tests done by ExcisionBio on monkeys for their CRISPR therapy for HIV). So I don't expect that (if everything works as expected) there will be bigger delays at that point. Usually when the funding from NIH ends, the research should have managed to run extensive tests on animals to gather further funding (often private) to move toward clinical trials. This period is called "the valley of death"; if there is not enough evidence that the therapy is effective, it will be more difficult to gather the attention of private investors and the research will run on lower funds and it will slow down or it will be stopped. Also: since it is a therapeutic application, the clinical trials might be faster than a prophylactic vaccine, unless side effects arise. There is no need to check that the therapy is protective on the long time, waiting for the participants to expose themselves to a pathogen (I also would not expect that they will check the condition of a participant for too long, because he might have exposed himself to another strain of herpes or the same one, if immunity will decrease after the therapy).  Hopefully once the first successful clinical trial, they will be able to get a fast-track and early-access as it happened with pritelivir.
    • asdfz
      Any CRISPR updates for HSV?
    • Ohsotired
      I don’t know why, but I decided to research the drug/medicine implementation process this morning. In my quest of knowledge, I found some disheartening information. Most researchers spend 3-6 years in the preclinical stage of research, 3-7 years in the clinical phase, and 2-5 years afterwards to launch the drug for public use. That’s Titans about 18 years in all for a drug to make it to mainstream.  Dr. Jerome has been working for nearly 10 years & has not finished the preliminary preclinical data. He’s only completed work with mice: no guinea pigs or monkeys. The reality set in that there’s so much more time needed. Hopefully, he doesn’t take nearly 10 more years to complete the next studies.    Afterwards, he’ll need to conduct a Phase I trial on humans, followed by a Phase IIa trial, proof of concept trial, Phase IIb trial,   Phase III trial, & regulatory review.  I was cautiously optimistic, but I’m starting to become cynical. This could take upwards to 20 years.   
    • Just a human being
      Try google T cells gut flora encephalitis. Can try to find it if u can’t.  I know Wilso could crack it but it common knowledge and educated on in groups by well respected HSV advocates from organisations that the virus can travel via other nerve routes. Whether this has any baring or truth in your case at all no idea. 
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tttlllhhh

Disclosure after sex

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tttlllhhh

This is so hard to write. I am in a shame spiral right now. I went out on a few dates with a man, he's 66 and I'm 57. I told him I wanted to get to know him, but we had more than a few drinks and ended up having sex - no condom. Unfortunately, it's our age group that does this I think.

I just officially found out about 2 months ago that I tested positive for HSV1 and 2, and that was only because I was going through my medical record for something else and saw it on a sheet that had my STD's testing. I was getting tested yearly. With that being said, I had a suspicion that I may have HSV2 from way back when, but in the 80's they didn't test for this. I went to my Dr. more than once and more than one doctor. All told me I didn't have genital herpes. I didn't have an outbreak, only a sensitive area.

So fast forward and I get a small blister line about an inch long right above my butt crack. (sorry for the graphic) And because I'm retired military and seen different doctors, I just told my civilian Dr. that I had herpes and needed medication. He gave me the medication. So from that point forward, no one questioned it. But the outbreak on my lower back eventually started happening often like every 1-2 months. Still no genital outbreaks, but the rare sensitive spot. So my civilian doctor said I needed to go on Valcyclovir for a year and then I should be ok. That was around 2005. Well, I never went off it. I took 500mg every day until about 4 years ago and I asked for 1000mg, because I was getting the inch long blister line. The blister(s) never busted open.

So, I felt like I had to tell this new guy about having HSV2. I explained to him as much as I could and the history, being on suppression therapy, etc. He took it well, thanked me for telling him and for being honest and courageous. And I told him because I was over his house and we were heavy petting and I felt like I absolutely had to tell him before a 2nd time, because morally I needed to do it and also because I was starting to like him, and, nonetheless, felt like I had no choice. I was going to have to bite the bullet and deal with however his reaction would be.  We had made plans to go out on Saturday night (tomorrow), and he asked me if we were going out, etc., and I said yes. However, I felt he probably needed a few days to think this over, because he may just change his mind.

Well, tonight his attitude changed. He still asked me out, but he was more flippant about seeing me, ie after "happy hour" he would text me when he got home vice the other plans he gave me a choice of doing.  I wasn't interested in going to happy hour because I'm not a big drinker. I wanted to get to know him.

So by the end of our texting, he told me I was disgusting, sick, selfish, I wasn't worth it, unforgiving, and more.  I had apologized to him more than once in person and through text. But I did get a little defensive and said I wasn't going to be shamed by him or anyone else, and that this doesn't make me less than. He also sort of threatened me and said "If I get your STD you've got a big problem!"  And I have no idea what he meant by that, not that I'm afraid of him. I'm wondering if he could sue me, not that I have anything for him to get from me. I'm thinking of the embarrassment of a law suit. But that would then mean he's making it public about himself too. 

I'm not sure what I need here. I feel like a POS. I did make a horrible mistake, and I do not know how to correct it. 

Also, I've been in long term relationships and have had no one have an outbreak or issues.

What's the chances of him contracting HSV2 from me? I would think low since I've been on suppression therapy 14+ years.  Can someone help?

 

 

 

 

Edited by tttlllhhh

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CookieSC

Here's some information I copied and pasted from justherpes.com (Admins: if not cool, please accept my apologies and thank you for editing.)  If anyone in the community feels this isn't reliable information, please comment and direct to more reliable sources.    
The likelihood of passing genital herpes to a partner is highest during an outbreak (times when a sore is present).

  • When a person is not experiencing an outbreak, there is a 4-10% chance of transmitting it. (Depending on gender)

According to studies done by Valtrex, these are the rates of transmission per year of regular sex:

  • If partners avoid sex during outbreaks: 4% chance transmission from female to male; 8% male to female
  • If partners also use condoms or antiviral medication: 2% female to male; 4% per year male to female
  • If partners also use condoms and antiviral medications: 1% female to male; 2% male to female

 

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CookieSC

You made a mistake and you apologized for it.  He lashed out at you because he's afraid, and worried, and probably a little angry at himself for not being responsible for his own sexual health.  Please try not to beat yourself up about it too much. There's nothing more you can do except what you did, which is apologize.  Making mistakes in relationships is part of learning how to be in relationships. You learned something important that will help you in the future.  The man you were dating learned something he needed to learn, as well.  In addition, you learned a lot about his character and how he might behave towards you in the future.  I think you dodged a bullet.  

Try not to worry too much.  It will be what it will be, and the likelihood that he contracted herpes from you is probably very small, as is a herpes lawsuit.  He most likely won't hesitate to be tested.  If he tests positive, depending on the type of test, it might even hint at if he was recently infected or if he's had it and just wasn't aware. 

A lot of people assume that, just because they haven't seen anything and they feel fine, they are free of STDs.  Getting tested for HSV2 and other STDs before starting a sexual relationship, whether a potential partner accepts or rejects, is always a good idea and I've suggested it during "the talk."  I had to specifically request screening for HSV2 when going in for pre-relationship STD panels.  There's a fair chance that a potential partner already has H2, which would take a lot of worry and need for protective measures out of the equation.

 

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Quest
9 hours ago, CookieSC said:

Here's some information I copied and pasted from justherpes.com (Admins: if not cool, please accept my apologies and thank you for editing.)  If anyone in the community feels this isn't reliable information, please comment and direct to more reliable sources.    
The likelihood of passing genital herpes to a partner is highest during an outbreak (times when a sore is present).

  • When a person is not experiencing an outbreak, there is a 4-10% chance of transmitting it. (Depending on gender)

According to studies done by Valtrex, these are the rates of transmission per year of regular sex:

  • If partners avoid sex during outbreaks: 4% chance transmission from female to male; 8% male to female
  • If partners also use condoms or antiviral medication: 2% female to male; 4% per year male to female
  • If partners also use condoms and antiviral medications: 1% female to male; 2% male to female

 

Love the site and it is ok to post! Everyone should visit the site

I really look up to anyone who discloses anytime!

They have really set it up to shame us and CDC says that most don't disclose. And we wonder why people don't disclose? The United States is one of the ones who thinks sex is dirty. What utter nonsense! I spent my first few years in shame, what a crock! 

Quote

 

 I felt like I had to tell this new guy about having HSV2. I explained to him as much as I could and the history, being on suppression therapy, etc. He took it well, thanked me for telling him and for being honest and courageous. And I told him because I was over his house and we were heavy petting and I felt like I absolutely had to tell him before a 2nd time, because morally I needed to do it and also because I was starting to like him, and, nonetheless, felt like I had no choice. I was going to have to bite the bullet and deal with however his reaction would be.  We had made plans to go out on Saturday night (tomorrow), and he asked me if we were going out, etc., and I said yes. However, I felt he probably needed a few days to think this over, because he may just change his mind.

Well, tonight his attitude changed. He still asked me out, but he was more flippant about seeing me, ie after "happy hour" he would text me when he got home vice the other plans he gave me a choice of doing.  I wasn't interested in going to happy hour because I'm not a big drinker. I wanted to get to know him.

So by the end of our texting, he told me I was disgusting, sick, selfish, I wasn't worth it, unforgiving, and more.  I had apologized to him more than once in person and through text. But I did get a little defensive and said I wasn't going to be shamed by him or anyone else, and that this doesn't make me less than. He also sort of threatened me and said "If I get your STD you've got a big problem!

 

Heavy petting won't transfer an STD. Unless you want to describe in detail how he had an open skin wound and your juices overwhelmed him. Did you grind him nude? Was he rubbing his trunk, with a skin wound, up and down your butt crack? 

He's just immature and nasty! I hope you see his true colors! You dogged a bullet! You are so lucky to find out that he would run if you got sick!

@Cas9

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