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When do you think we will have an update from Dr Jerome?


iFdUp

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Just curious what peoples thoughts are on when we might have an update from Dr Jeromes team. 

I tried to see if there was any pattern to updates but there does not seem to be one. 

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9 hours ago, MikeHerp said:

I think there's a decent chance we'll get an update before year end.  

Just the man I wanted to hear from. 

My feeling is that the teams prior results were just too good for some serious progress not to have been made in the last 6 ~ months. 

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46 minutes ago, iFdUp said:

Just the man I wanted to hear from. 

My feeling is that the teams prior results were just too good for some serious progress not to have been made in the last 6 ~ months. 

 

10 hours ago, MikeHerp said:

I think there's a decent chance we'll get an update before year end.  

God I hope you two are right. 

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2 hours ago, iFdUp said:

Just the man I wanted to hear from. 

My feeling is that the teams prior results were just too good for some serious progress not to have been made in the last 6 ~ months. 

It’s just a question of time. Their marketing manager promised us an update. And we know what exactly Jerome’s team was going to do next. Let’s sit tight and wait. I know it’s coming.

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Hi all,

A few things I noticed here.  Dr. Jerome's experiments are being done on mice with HSV1

When he's talking about the viral load, it's mostly in the TG, which they were up to 50% in and the SCG has less virus, which they were getting the 90% on.  These are the different types of neurons that have the HSV1 virus. 

So, I am wondering if he's going to also do the experiment on HSV2 infected mice after perfecting the HSV1 delivery.  Maybe someone who has already been in touch with the lab knows or could ask if they've been in communication already with them.  I don't know how different HSV2 would be as far as delivery to the neurons goes.

BTW, I did make a donation to the cause ;)

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On 7/29/2019 at 6:28 PM, MikeHerp said:

 

It’s just a question of time. Their marketing manager promised us an update. And we know what exactly Jerome’s team was going to do next. Let’s sit tight and wait. I know it’s coming.

What exactly were they going to do next, do you believe? I think I recall Dr Jerome saying they were going to try to figure out why only 90% and work on getting that number up. Right? 

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Right, they are going to work on improving the delivery to the TG, which was at 50% and also try to improve the SCG 90% to as much as possible.  Essentially, keep improving  to reach more of of the neurons with HSV1 in them., especially the TG ones. 

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Right. They have a good idea how efficiency can be improved. Now they are trying to execute it. Note that working with meganucleases can take months.

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3 hours ago, Hopeful heart said:

Right, they are going to work on improving the delivery to the TG, which was at 50% and also try to improve the SCG 90% to as much as possible.  Essentially, keep improving  to reach more of of the neurons with HSV1 in them., especially the TG ones. 

What about neurons infected in the brain? HSV is know to reactivate and go the other way into the brain through retrograde axonal transport.

likewise beyond the sacral ganglion into the spinal cord.

 

Not to mention the fact that one study showed nearly a quarter of cadavers harbored HSV in their olfactory bulbs ( I don’t think having it in this location requires an explanation of how easy infecting the rest of the brain would be, but brain wide spread seems frighteningly easy from here)

 

 

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5 hours ago, iFdUp said:

What exactly were they going to do next, do you believe? I think I recall Dr Jerome saying they were going to try to figure out why only 90% and work on getting that number up. Right? 

I think the issues were related to:

1. The best place to inject the AAV
2. The best AAVs to use for the specific nerve type. Right now, the AAV used for the TG is not as effective as it is for the SCG.
There are many AAVs and science can also create their own.

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1 hour ago, Tacotime said:

What about neurons infected in the brain? HSV is know to reactivate and go the other way into the brain through retrograde axonal transport.

likewise beyond the sacral ganglion into the spinal cord.

 

Not to mention the fact that one study showed nearly a quarter of cadavers harbored HSV in their olfactory bulbs ( I don’t think having it in this location requires an explanation of how easy infecting the rest of the brain would be, but brain wide spread seems frighteningly easy from here)

 

 

This is incorrect, the virus does not go to the brain through ‘axonal transport’.

The route for which HSV gets to the brain, which is about 1 in 500,000 people years, is unknown.

Likewise the meninge stops the virus from spreading into the spinal column. 

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Totally wrong @WilsoInAus and misleading people/ downplaying the capabilities of this virus yet again.

 

1. Extremely easy access to the brain via the olfactory route. Hence why 1 in 4 cadavers harbored virus in their olfactory bulbs.

2. HSV is the leading cause of infectious blindness in the developed world. Guess what the eyes are connected to and what herpes loves to live in and move freely through? Yup you guessed it the brain and nerves(optic nerve in this case.

3. HSV is proven to travel not just to the skin surface via reservoirs in the trigeminal ganglion but also in the other direction to the brain stem.

4. If HSV showing up in the brain were as rare as you suggested we wouldn’t have the incidence of Alzheimer’s, depression and other dementias that we do today. 

 

Just look these things up before trying to falsely reassure everyone (and yourself in the process) that this virus isn’t actively wreaking the havoc on everyone that it is.

 

 

 

 

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Oh where have you been @Tacotime we’ve missed the heights of herpes drama preceding the second coming.

but maybe this is it, yes maybe.

Perhaps you have one just one publication that supports any of the above? Or have you just pulled a mishapen stone of terror from your herpes riddled arse yet again!

1. Upon death the immune system breaks down, viruses and bacteria can do what they will.

2. Keratitis is serious. Note that you used the term infectious blindness and not total blindness.

3. There are no sensory nerve cells in the brain stem, hence the transmission mechanism into the spinal column is unknown and exceptionally rare.

4. Why do the same proportion of people with and without HSV-1 develop Alzheimer’s? Why is HSV-1 only found in a tiny percentage of plaques? We don’t even know if HSV-1 actually does anything in relation to AZ yet.

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@WilsoInAus oh buddy grow up please, will ya mate.

 

I think it’s best you stick to your area of expertise (such as reviewing film) since clearly you haven’t a clue about HSV.

 

1. When a person dies so to does the virus so the huge plaque load and lesions riddled with herpes viruses had to have happened as a result of years of accumulation. Not some spontaneous brain atrophy that happens as the result of death.

 

2. Yes keratitis is serious but plenty of subclinical herpes replication takes place in the eye hence access to the brain via the optic nerve.

We know HSV is causative in Alzheimer’s it’s just you standing alone in your own little sinking ship of denial.

The brain stem is full of neurons that can easily be infected by HSV via the trigeminal ganglion and then obviously free reign in the rest of the brain especially the prefrontal cortex that’s riddled with lesions.

Entry into the brain via optic nerves and olfactory nerves as well as via the trigeminal ganglion is quite common actually.

 

Try your best to overcome your limitations and embrace the truth! You can do it little Wilson! don’t let your insecurities and your desperate need to con others get the best of you! There are other ways to get a buzz try those instead of your usual reassuring suffering people that herpes isn’t driving their symptoms.

 

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@Tacotime all we want is just one piece of research that supports what you are saying.

I note you dodged that, because nothing you say is true or is a gross exaggeration.

For example, let’s see one article that shows HSV-1 is causative to AZ, proves it. Just one!

Or can’t you? And what does that say about all the other falsehoods you have written.

But let’s start with your biggest falsehood.

just one article, not much to ask for now, is it?

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2 hours ago, iFdUp said:

Wilson is disrupting my thread despite me having him blocked, great. 

 

Exactly, this thread has been hijacked into ridiculous territory. I mean what has AZ got to do with this thread?

Yet YOU have done NOTHING to correct the people who have done this to the thread whereas I have.

If you are concerned, then please report the people to administrators as I have done and call it out.

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@Tacotime 

Your comments regarding “brain stem is full of neurons that can easily be infected by HSV” are not true and I will explain why.

All cells in the body are different and carry immunity to viruses. Neurons are a special type of cell that produce interferons (INF). There are a multitude of different types of neurons within our total nervous system. Their INF response is also distinctive for each type of neuron. 

INF are amazing, they essentially block viruses from spreading to nearby cells and they provide a marker for killer cells to come along and kill off the virus. Many viruses are thus cleared from the body completely. HSV 1/2/3 do not get cleared. Why? Because their DNA makeup is such that they can fool a limited range of neurons not to produce a full INF response. Over the past number of years, you will find a few posts by myself and others on this topic as well.

In short, HSV 1/2 have learnt to prevent the INF response of sensory neurons. However, the INF of other types of neurons does its job for 99.99% of people in preventing infection of other neuron types their entire lives.

This is arduous research, but nevertheless there are two important findings:

- INF and associated immune elements that are signalled do eradicate the virus, it happens for the skin cells as the virus is rubbed onto the body. Although it is not likely to be the most efficient approach to eradicating the virus, it is theorised that if you could stimulate the INF response of sensory cells, eradication may be feasible.

- There are possibly genetic markers that mean cells other than sensory neurons have deficient INF responses and means that they are predisposed toward encephalitis.

Anyway that’s the context for the following statements:

- HSV 1/2 has learnt to prevent the full force of the INF cell response in sensory neurons. It is however only ‘muted’ and its possible INF is an explanation of HSV latency.

- For other types of neurons, INF eradicates the virus and prevents infection

There’s some really deep science in this stuff, but the interested reader might find the following paper to be amongst the most accessible on the topic.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4508759/

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@WilsoInAus thank you. 😂 You just literally proved my point by pointing out how HSV shuts off interferon responses in neurons to enable infection of them.  

Please stop polluting this thread.

 

Hope we have an update from Jerome soon.

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2 minutes ago, Tacotime said:

@WilsoInAus thank you. 😂 You just literally proved my point by pointing out how HSV shuts off interferon responses in neurons to enable infection of them.  

Please stop polluting this thread.

 

Hope we have an update from Jerome soon.

Yes that’s correct HSV shuts down IFN for SENSORY neurons only. The IFN of orher neurons works very effectively against HSV such as those found in the brain stem and many other cell types found in the body.

Pleas next time you pollute a thread with your senseless fear... please think twice. It might help if you actually read a paper or two as well.

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  • 1 month later...

Dr Jerome at defeat HIV August 2019. Found this on HutchIDSciences twitter.

Would be nice if we can find a video of the conference. 

ECnJKGmU4AAzxNA.jpg:large

Community Summary

Question: Can gene editing be used against other lifelong viral infections besides HIV?

Major finding: Gene editing can lead to the elimination of the vast majority of latent herpes simplex virus from reservoir sites

Why is this important?

Lessons from one virus can tech us how to treat another.

The major driver for success in gene therapy is delivery.

---------------------------------------------------------------

I know it's not specific but "elimination of the vast majority" "from reservoir sites" sounds good.

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