BlueWillow Biologics awarded patent for intranasal genital herpes vaccine.

[TCBH]

Another company looking to create a vaccine.  http://www.bluewillow.com/bluewillow-biologics-awarded-patent-for-intranasal-genital-herpes-vaccine/

BlueWillow’s intranasal NanoVax platform elicits both mucosal and systemic immunity through its novel oil-in-water nanoemulsion (NE) adjuvant, offering a unique advantage to combat sexually transmitted infections (STIs) including genital herpes. The mucosal immunity elicited by intranasal NE vaccines provides critical protection against infections at the port of entry by which a pathogen enters the body.

The intranasal NanoVax HSV vaccine has demonstrated safety and efficacy in both prophylactic and therapeutic animal models for genital herpes. In a prophylactic guinea pig study, the intranasal vaccine prevented genital herpes infection in 92 percent of animals vaccinated. Therapeutic study animals previously infected with genital herpes who received the BlueWillow vaccine reduced recurrent lesions and viral shedding by more than 50 percent compared to animals who received no treatment.

[JHenry]

Looks exciting and interesting as well!  50% reduction in shedding isn’t exceptional when compared to Valtrex is it?  But as a prophylactic 92% is an impressive number.

Seems like suddenly, there is a lot of competition heating up, with new approaches.   We exist in a competitive world, driven by dollars—it’s just a matter of time I believe. 

While I do not believe in “conspiracies” I do believe there are companies out there that wants to knock the existing therapies off their perch and eventually one of them will become the next multi-billion dollar drug company, by killing herpes.

[TCBH]

3 hours ago, JHenry said:

Looks exciting and interesting as well!  50% reduction in shedding isn’t exceptional when compared to Valtrex is it?  But as a prophylactic 92% is an impressive number.

Seems like suddenly, there is a lot of competition heating up, with new approaches.   We exist in a competitive world, driven by dollars—it’s just a matter of time I believe. 

While I do not believe in “conspiracies” I do believe there are companies out there that wants to knock the existing therapies off their perch and eventually one of them will become the next multi-billion dollar drug company, by killing herpes.

Yes, maybe with the possibility hsv is the cause or a contributary to some Alzheimer cases it's looking a lot more lucrative to find a vaccine against it.  Can you imagine the payoff if it becomes a standard/routine vaccine?

[LightafterDarkness]

A patent is nice forward progress but wish we got more news on a phase I date

Both numbers are very good:

• a vaccine with a 92% chance reduction could help many people who are in relationships with someone who is hsv negative (so imagine partner has the vaccine + you are on antivirals = basically a <1% chance of passing it on?).
• Similarly a 50% reduction in shedding for a 1 time vaccine could be a nice addition to the standard meds (and/or hopefully pritelivir in 2020)

[JHenry]

1 hour ago, TCBH said:

Yes, maybe with the possibility hsv is the cause or a contributary to some Alzheimer cases it's looking a lot more lucrative to find a vaccine against it.  Can you imagine the payoff if it becomes a standard/routine vaccine?

Makes complete sense to me.  My mother never exhibited HSV1, but never exhibited.  I am all for whatever it takes!