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    • asdfz
      Hi, here seeking advice from those on Famvir for daily suppressive therapy. I’ve tried valtrex and get nasty side effects so I’m on Famvir. I was taking 375 every 12 hours which kept OBs away but I was getting 2 migraines a week. My doc said to try 250 every 8 hours. I’ve been on that about a week and constantly feel tingles. Is that normal when adjusting meds? Will it go away as my body adapts? Please help! 
    • Cas9
      @Ohsotired It took 10 years for mouse studies? Not sure if that's true, but anyway, it takes a while when starting out because you're kind of starting from scratch. That also involves in vitro work. Then you need to go to mice. So the in vitro and mice work is where a lot of the figuring out has taken place. It involved a lot of painstaking work. In fact Dr. Jerome started with an old style editor (CRISPR hadn't been invented yet). When he wasn't getting the results with whatever editor he was using, and CRISPR was invented, he then switched to CRISPR. He got worse results with that. His team then figured out what the issues were, step by step. And finally we are where we are; i.e. 90% and 50% cleavage in SCG and TG. And he knows what the issue is regarding improving those percentages to 90%+ in the DRG and TG. So a lot of the figuring out took a while and now we just need to see that it works in guinea pigs and then primates. Unless something goes wrong, and there's no reason to believe that it will, we are not going to take 10 years for each animal of course. If things go smoothly I would say 3 or 4 years. Then on to clinical. But we'll see. " Most researchers spend 3-6 years in the preclinical stage of research, 3-7 years in the clinical phase, and 2-5 years afterwards to launch the drug for public use. That’s Titans about 18 years in all for a drug to make it to mainstream. " So you chose the high end for each range. If I choose the low end for each it's 8 years. It's really impossible to predict. But I think the majority of us think that if it's successful it's at least 10 years away. Before your research, how long did you think the process would take? If it takes 10 years, how old will you be?
    • hk81
      The funding from NIH for the lab tests on mice will end in 2023, so this can give an idea on the timeline. https://grantome.com/grant/NIH/R01-AI132599-01A1 When the tests are moved to bigger animals (guinea pig and monkey), the possibility of experimentation is lower due to higher costs. The tests on monkeys are done only when the research has reached some solid results and only a few combinations are tested (see for example the tests done by ExcisionBio on monkeys for their CRISPR therapy for HIV). So I don't expect that (if everything works as expected) there will be bigger delays at that point. Usually when the funding from NIH ends, the research should have managed to run extensive tests on animals to gather further funding (often private) to move toward clinical trials. This period is called "the valley of death"; if there is not enough evidence that the therapy is effective, it will be more difficult to gather the attention of private investors and the research will run on lower funds and it will slow down or it will be stopped. Also: since it is a therapeutic application, the clinical trials might be faster than a prophylactic vaccine, unless side effects arise. There is no need to check that the therapy is protective on the long time, waiting for the participants to expose themselves to a pathogen (I also would not expect that they will check the condition of a participant for too long, because he might have exposed himself to another strain of herpes or the same one, if immunity will decrease after the therapy).  Hopefully once the first successful clinical trial, they will be able to get a fast-track and early-access as it happened with pritelivir.
    • asdfz
      Any CRISPR updates for HSV?
    • Ohsotired
      I don’t know why, but I decided to research the drug/medicine implementation process this morning. In my quest of knowledge, I found some disheartening information. Most researchers spend 3-6 years in the preclinical stage of research, 3-7 years in the clinical phase, and 2-5 years afterwards to launch the drug for public use. That’s Titans about 18 years in all for a drug to make it to mainstream.  Dr. Jerome has been working for nearly 10 years & has not finished the preliminary preclinical data. He’s only completed work with mice: no guinea pigs or monkeys. The reality set in that there’s so much more time needed. Hopefully, he doesn’t take nearly 10 more years to complete the next studies.    Afterwards, he’ll need to conduct a Phase I trial on humans, followed by a Phase IIa trial, proof of concept trial, Phase IIb trial,   Phase III trial, & regulatory review.  I was cautiously optimistic, but I’m starting to become cynical. This could take upwards to 20 years.   
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difficultroadahead

Is it possible to have GHSV1 and GHSV2

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difficultroadahead

Hi All was just wondering if the above is possible??.

My story...

2016 I noticed 2 blisters on shaft of my penis.I did not have any other symptoms of herpes. I popped them and went to a dermatoligist asking if it was herpes,he said no looked like some sort of bacterial skin infection gave me some creams and antibiotics and sent me on my way.

Anyway fastforward to June this year ,all of a sudden I had a prodrome of tingling on my skin like something was crawling. 4hrs later 2 blisters appeared again on the shaft of my penis.I really got concerned as I had had protecected sex with a new partner a week prior.

So i went to 3 gps and 1 proffessor of Derm who all said it was not herpes,I was still unsure and went to A 4th GP who said this looked like clinical herpes.Sent me for bloods and put me on 5days Valtrex.

So bloods results came back as follows HSV-1 IGG positive ,HSV-2 IGG Negitive and IGM HSv 1 and 2 Positve. so was not sure if this was Ghsv1. doc said that our tests here in South Africa Cannot distinguish between HSV1 And 2

Anyway 6weeks later went for another blood test and this time all came back positive.

What are you guys thoughts on this?

Could it be just GHSV 1 from a few years ago or Ghsv2 from new infection?

Thanks for a wonderful forum

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WilsoInAus

Hey @difficultroadahead and welcome to the website.

Let’s go with the simplest explanation here. Note that there is other possibilities included underneath.

First you disregard the IgM test, not useful especially if you carry one type already.

Your IgG tests are type specific by the look of them. I understand you had HSV-1 positive and HSV-2 negative within a couple of weeks after the sores appeared. Now 6 weeks later IgG HSV-2 is also now positive - correct.

This suggests you have had an oral HSV-1 infection since childhood. It also suggests you were infected during the incidence you describe in June a week before sores. That’s a fit to the facts and a pretty decent fit.

Other possibilities include that you have experienced a false positive for HSV-2. If this were true, you probably wouldn’t have genital herpes at all. You have enough data here to be able to ask this partner to test (please) to assist in understanding if you do have HSV-2 and whether you are concordant with them or need further testing.

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difficultroadahead

Hi Wilsoln

Thanks for your reply.

Tell me is it possible to have GHSV 1 and 2

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WilsoInAus
22 minutes ago, difficultroadahead said:

Hi Wilsoln

Thanks for your reply.

Tell me is it possible to have GHSV 1 and 2

It is feasible, but theoretical, extremely low chances. 

It is way less likely than a false positive on your HSV-2 for example.

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difficultroadahead

hi

so its possible that this was a reoccurent outbreak from the initial 2016

best bet would be to wait another 4 weeks and go for another blood test

 

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WilsoInAus

Yes it is a possible recurrent, but that wouldn’t explain the now positive HSV-2 outcome which you need to prove was a false positive.

Could you ask the partner in June to test as well?

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TCBH

From the American Sexual Health Association:  The accurate herpes blood tests detect IgG antibodies. Unlike IgM, IgG antibodies can be accurately broken down to either HSV-1 or HSV-2. ... However, since most cases of genital herpes are caused by HSV-2, a positive result for type-2 antibodies most likely indicates genital herpes.

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difficultroadahead
On 8/6/2019 at 9:52 PM, WilsoInAus said:

Yes it is a possible recurrent, but that wouldn’t explain the now positive HSV-2 outcome which you need to prove was a false positive.

Could you ask the partner in June to test as well?

Hi Wilsoln

Mange to get my results from the lab

igm is 0.9 negative

igg for hsv 2 is 2.1 which says positive

it was elisa test what would you make of these index values

thanks

 

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WilsoInAus
2 hours ago, difficultroadahead said:

Hi Wilsoln

Please help with above

Thanks

Hey mate, sorry I missed your previous post.

Upon a reread and a think, what I said initially is pretty much spot on.

At this stage you can not distinguish between:

- a recent infection of HSV-2; and

- a false positive for HSV-2.

The result at 2.1 is poised to support both these possibilities.

As the Westernblot is probably not available as a tye breaker for you, the following should sort it out:

- a test by the partner to see if HSV-2 was even a risk would be incredibly useful, if they have it then a further positive test particular with a higher number would push the situation close to beyond reasonable doubt.

- a further blood test for you regardless is needed to compare, it may be negative or firmly positive (above 3.5) to leave little doubt. If it comes back low positive (1.1 to 3.5) then a reasonable doubt would still exist in the absence of knowing the partner’s status.

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difficultroadahead

Hi Wilsoln

Thank you so much for your feedback.

Just passed the 12 weeks ,maybe the anitbodies were still building up thats why it was a low positive of 2.1

On another note do you think a burning sensation on the palm of the hand is in anyway linked to Herpes as lots of people say it can affect the nerves

Been getting this sensation almost every other day now

Thanks

 

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WilsoInAus

Hey @difficultroadahead there are a few possibilities that you need to get to the bottom of. When are you testing next? Can you ask your partner to test?

Herpes infects the sensory nerves of the sacral ganglion. The virus will generally not travel the body to other ganglions. Hence your palm is an unrelated issue.

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difficultroadahead
37 minutes ago, WilsoInAus said:

Hey @difficultroadahead there are a few possibilities that you need to get to the bottom of. When are you testing next? Can you ask your partner to test?

Herpes infects the sensory nerves of the sacral ganglion. The virus will generally not travel the body to other ganglions. Hence your palm is an unrelated issue.

Hi This is a new test done at 11 weeks since june.

Partner has refused to test saying nothing wrong with her unfortunetaly for me.

Does the antibodies index level increase over time as more antibodies are built up?

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