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    • Miss Horne
      It worked wonderfully @Kurdt01, I’m just too fucking broke to buy it! 
    • Miss Horne
      When I was diagnosed we were all gearing up for the Frazer, Gen003 and Halford therapeutic vaccines, all flopped. Pritlevir trials were suspended and there was nothing else really on the table. Some 6 years later Pritlevir has been fast tracked, Gen003 might be back in the running and a member of our forum is taking part in a monoclonal trial (with good results I understand). Best of all Dr Jerome has actually partially cured hsv in mice and thanks to our donations will be progressing to other animal modules soon. My point being time flies and there is so much more research going on now. I understand the frustration, we all do but please don’t get disheartened, like I say we are in a much better position now than we were just a couple of years ago. 
    • asdfz
      Hi, here seeking advice from those on Famvir for daily suppressive therapy. I’ve tried valtrex and get nasty side effects so I’m on Famvir. I was taking 375 every 12 hours which kept OBs away but I was getting 2 migraines a week. My doc said to try 250 every 8 hours. I’ve been on that about a week and constantly feel tingles. Is that normal when adjusting meds? Will it go away as my body adapts? Please help! 
    • Cas9
      @Ohsotired It took 10 years for mouse studies? Not sure if that's true, but anyway, it takes a while when starting out because you're kind of starting from scratch. That also involves in vitro work. Then you need to go to mice. So the in vitro and mice work is where a lot of the figuring out has taken place. It involved a lot of painstaking work. In fact Dr. Jerome started with an old style editor (CRISPR hadn't been invented yet). When he wasn't getting the results with whatever editor he was using, and CRISPR was invented, he then switched to CRISPR. He got worse results with that. His team then figured out what the issues were, step by step. And finally we are where we are; i.e. 90% and 50% cleavage in SCG and TG. And he knows what the issue is regarding improving those percentages to 90%+ in the DRG and TG. So a lot of the figuring out took a while and now we just need to see that it works in guinea pigs and then primates. Unless something goes wrong, and there's no reason to believe that it will, we are not going to take 10 years for each animal of course. If things go smoothly I would say 3 or 4 years. Then on to clinical. But we'll see. " Most researchers spend 3-6 years in the preclinical stage of research, 3-7 years in the clinical phase, and 2-5 years afterwards to launch the drug for public use. That’s Titans about 18 years in all for a drug to make it to mainstream. " So you chose the high end for each range. If I choose the low end for each it's 8 years. It's really impossible to predict. But I think the majority of us think that if it's successful it's at least 10 years away. Before your research, how long did you think the process would take? If it takes 10 years, how old will you be?
    • hk81
      The funding from NIH for the lab tests on mice will end in 2023, so this can give an idea on the timeline. https://grantome.com/grant/NIH/R01-AI132599-01A1 When the tests are moved to bigger animals (guinea pig and monkey), the possibility of experimentation is lower due to higher costs. The tests on monkeys are done only when the research has reached some solid results and only a few combinations are tested (see for example the tests done by ExcisionBio on monkeys for their CRISPR therapy for HIV). So I don't expect that (if everything works as expected) there will be bigger delays at that point. Usually when the funding from NIH ends, the research should have managed to run extensive tests on animals to gather further funding (often private) to move toward clinical trials. This period is called "the valley of death"; if there is not enough evidence that the therapy is effective, it will be more difficult to gather the attention of private investors and the research will run on lower funds and it will slow down or it will be stopped. Also: since it is a therapeutic application, the clinical trials might be faster than a prophylactic vaccine, unless side effects arise. There is no need to check that the therapy is protective on the long time, waiting for the participants to expose themselves to a pathogen (I also would not expect that they will check the condition of a participant for too long, because he might have exposed himself to another strain of herpes or the same one, if immunity will decrease after the therapy).  Hopefully once the first successful clinical trial, they will be able to get a fast-track and early-access as it happened with pritelivir.
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IamPositive

The worst outbreak after So many years..

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IamPositive

My previous outbreaks has always under control, just one two blisters, or popped out around my thighs. But it’s never been so painful or itchy. Unlike this one.. this one is a real sh*t. I have blisters all around my labia, perianal, and my mons pubis. It’s so itchy, sore, and painful.  Every time I use the bathroom or shower I wish I could just kill myself. Been in valtrex 1500mg a day for the past 4days and no improvement to the pain+itch+blisters. This is the worst OB ever.. I can’t sleep, I can’t sit or walk comfortably without in pain.. 😭😭😭😭.

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Radium

The worst thing about this is the discomfort when the lesions appear in inconvenient spots. My first two OB's.. Really uncomfortable, non-stop new lesions every few days, both lasting for about 3 weeks. Itchy at times, and very uncomfortable to wear pants when the lesions are constantly rubbing against them and breaking open during the healing process. Ugh.

Third ob started a week ago, only one spot with about 17 small blisters in a 15x10mm area, healed in 7 days. In the first few days, penis was extremely itchy and swollen around the area and I thought the OB will continue for weeks again, but nothing else appeared. I'm not taking AVs but I did apply some 99% DMSO + 3% H2O2 topically in the region on the 2nd day. Cannot confirm if that had anything to do with stopping the OBs, but I am pleased to see that the OB was much milder this time.

Take care, it'll be over soon.

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IamPositive
7 hours ago, Radium said:

The worst thing about this is the discomfort when the lesions appear in inconvenient spots. My first two OB's.. Really uncomfortable, non-stop new lesions every few days, both lasting for about 3 weeks. Itchy at times, and very uncomfortable to wear pants when the lesions are constantly rubbing against them and breaking open during the healing process. Ugh.

Third ob started a week ago, only one spot with about 17 small blisters in a 15x10mm area, healed in 7 days. In the first few days, penis was extremely itchy and swollen around the area and I thought the OB will continue for weeks again, but nothing else appeared. I'm not taking AVs but I did apply some 99% DMSO + 3% H2O2 topically in the region on the 2nd day. Cannot confirm if that had anything to do with stopping the OBs, but I am pleased to see that the OB was much milder this time.

Take care, it'll be over soon.

Why you never been on AV during your initial outbreak? I wish i knew when i got my first, so I could take AV. Well..life is sucks sometimes.. and I have infant.. I guess I’m overtired. Past few weeks I only managed to get 4-5hours sleep everyday as I’m back to work.

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Skye249

@IamPositive How long have you had the virus for? Do you suspect there is something going on with your immune system or does the severity of the outbreak seem random?

I've had HSV2 for four years. Whenever I had a visible outbreak, including the primary one, I had one small lump in a specific area. In May, I had an outbreak and the lump was bigger and more painful , but in the same place. Two days ago I had another outbreak with three large and painful lumps in new places. It's a fresh kind of hell.

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IamPositive
On 10/6/2019 at 3:33 AM, Skye249 said:

@IamPositive How long have you had the virus for? Do you suspect there is something going on with your immune system or does the severity of the outbreak seem random?

I've had HSV2 for four years. Whenever I had a visible outbreak, including the primary one, I had one small lump in a specific area. In May, I had an outbreak and the lump was bigger and more painful , but in the same place. Two days ago I had another outbreak with three large and painful lumps in new places. It's a fresh kind of hell.

More than 6years... and the outbreak getting worst and worst now. I have outbreaks like every month 😭😭😭😭😭😭😭😭 sometimes, I just want to kill myself..

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KelsMichelle
On 9/18/2019 at 12:19 AM, IamPositive said:

My previous outbreaks has always under control, just one two blisters, or popped out around my thighs. But it’s never been so painful or itchy. Unlike this one.. this one is a real sh*t. I have blisters all around my labia, perianal, and my mons pubis. It’s so itchy, sore, and painful.  Every time I use the bathroom or shower I wish I could just kill myself. Been in valtrex 1500mg a day for the past 4days and no improvement to the pain+itch+blisters. This is the worst OB ever.. I can’t sleep, I can’t sit or walk comfortably without in pain.. 😭😭😭😭.

I feel this pain. I’ve had it for 3.5 years and was only getting 1 ob a year on antivirals. Now they seemed to have stopped. I’m getting obs every 2-3 weeks. It’s too much. I’ve had like 10 since June it feels like. I’m constantly depressed because even though I’ve accepted having it, to deal with it and be reminded every month is too much. Considering ditching the antivirals. What good are they doing me anyway. 

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KelsMichelle
5 hours ago, p6580 said:

Have you tried Lysine?  It seems to really work well for many! 

 

On and off I have..I just ran out of the supplement and haven’t gotten more. May try getting more

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