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    • asdfz
      Hi, here seeking advice from those on Famvir for daily suppressive therapy. I’ve tried valtrex and get nasty side effects so I’m on Famvir. I was taking 375 every 12 hours which kept OBs away but I was getting 2 migraines a week. My doc said to try 250 every 8 hours. I’ve been on that about a week and constantly feel tingles. Is that normal when adjusting meds? Will it go away as my body adapts? Please help! 
    • Cas9
      @Ohsotired It took 10 years for mouse studies? Not sure if that's true, but anyway, it takes a while when starting out because you're kind of starting from scratch. That also involves in vitro work. Then you need to go to mice. So the in vitro and mice work is where a lot of the figuring out has taken place. It involved a lot of painstaking work. In fact Dr. Jerome started with an old style editor (CRISPR hadn't been invented yet). When he wasn't getting the results with whatever editor he was using, and CRISPR was invented, he then switched to CRISPR. He got worse results with that. His team then figured out what the issues were, step by step. And finally we are where we are; i.e. 90% and 50% cleavage in SCG and TG. And he knows what the issue is regarding improving those percentages to 90%+ in the DRG and TG. So a lot of the figuring out took a while and now we just need to see that it works in guinea pigs and then primates. Unless something goes wrong, and there's no reason to believe that it will, we are not going to take 10 years for each animal of course. If things go smoothly I would say 3 or 4 years. Then on to clinical. But we'll see. " Most researchers spend 3-6 years in the preclinical stage of research, 3-7 years in the clinical phase, and 2-5 years afterwards to launch the drug for public use. That’s Titans about 18 years in all for a drug to make it to mainstream. " So you chose the high end for each range. If I choose the low end for each it's 8 years. It's really impossible to predict. But I think the majority of us think that if it's successful it's at least 10 years away. Before your research, how long did you think the process would take? If it takes 10 years, how old will you be?
    • hk81
      The funding from NIH for the lab tests on mice will end in 2023, so this can give an idea on the timeline. https://grantome.com/grant/NIH/R01-AI132599-01A1 When the tests are moved to bigger animals (guinea pig and monkey), the possibility of experimentation is lower due to higher costs. The tests on monkeys are done only when the research has reached some solid results and only a few combinations are tested (see for example the tests done by ExcisionBio on monkeys for their CRISPR therapy for HIV). So I don't expect that (if everything works as expected) there will be bigger delays at that point. Usually when the funding from NIH ends, the research should have managed to run extensive tests on animals to gather further funding (often private) to move toward clinical trials. This period is called "the valley of death"; if there is not enough evidence that the therapy is effective, it will be more difficult to gather the attention of private investors and the research will run on lower funds and it will slow down or it will be stopped. Also: since it is a therapeutic application, the clinical trials might be faster than a prophylactic vaccine, unless side effects arise. There is no need to check that the therapy is protective on the long time, waiting for the participants to expose themselves to a pathogen (I also would not expect that they will check the condition of a participant for too long, because he might have exposed himself to another strain of herpes or the same one, if immunity will decrease after the therapy).  Hopefully once the first successful clinical trial, they will be able to get a fast-track and early-access as it happened with pritelivir.
    • asdfz
      Any CRISPR updates for HSV?
    • Ohsotired
      I don’t know why, but I decided to research the drug/medicine implementation process this morning. In my quest of knowledge, I found some disheartening information. Most researchers spend 3-6 years in the preclinical stage of research, 3-7 years in the clinical phase, and 2-5 years afterwards to launch the drug for public use. That’s Titans about 18 years in all for a drug to make it to mainstream.  Dr. Jerome has been working for nearly 10 years & has not finished the preliminary preclinical data. He’s only completed work with mice: no guinea pigs or monkeys. The reality set in that there’s so much more time needed. Hopefully, he doesn’t take nearly 10 more years to complete the next studies.    Afterwards, he’ll need to conduct a Phase I trial on humans, followed by a Phase IIa trial, proof of concept trial, Phase IIb trial,   Phase III trial, & regulatory review.  I was cautiously optimistic, but I’m starting to become cynical. This could take upwards to 20 years.   
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HSV2Mom

Long Term Effects In Infants, etc.

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HSV2Mom

Can anyone point me in the direction for learning about the long term effects of herpes in children born to mothers with HSV2?

I have HSV2 and gave birth to my daughter who had no signs or symptoms of neonatal herpes. We are starting to see little bumps appearing sparatically on her vagina and parts of her anus which makes us worry whether she is a carrier. We certainly don't want her to suffer from our mistakes and we worry that later on in life she will start having outbreaks.

Does anyone know the long term effects?

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VVK

hsv2mom,

I'm sorry that nobody has answered your questions before and I haven't found your message. You should get your girl checked out by a doc to rule out other conditions along with herpes.

The symptoms of neonatal herpes are usually very severe, so I doubt that this is the problem you are seeing right now. However, other types of rashes that appear aren't just something that should be ignored.

If you are still curious about long-term effects of neonatal herpes or just genital herpes acquired at an early age, please state so.

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ouch

Sounds to me like some type of rash. How old is you daughter.

Generally, infants born with neonatal herpes do not necessarily get herpes on their genitals. It is EVERYWHERE. And usually it shows up 2-14 days from birth. Sometimes later, but not much. You would definitely know.

But if you are concerned, just for peace of mind take her to her pediatrician for testing. Tell him/her your fears if you have to. It could be a rash, or it could be a yeast type of "rash". (hence the bumps.) But it is best to have her checked by her doctor while the bumps are present.

I am sure all is well, but again, just to allay your fears, take her in to her doctor.

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Caliope

I'd consult a pediatrician to know for certain but it is very common for infants to get rashes in the diaper area from candida albicans. This is also called thrush or yeast.

It is important to keep the diaper area clean and dry. When my son was tiny I'd rinse him in the sink after each diaper change and dry his diaper area completely and then apply a thin coat of desitin cream that contains zinc. An alternative to the cream is using a baby powder all over her diaper area and making sure to get it into any creases where moisture might collect.

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ONtrialFEM

Maybe STAPH

My son and I had a STAPh infection...the MRSA resistant form. anywho it can cause hard pimple like things anywhere vagina buttocks penis. Please I know it is scary to go to the docs, I had no choice when I saw a blister near his circumcision at 7 days old...was staph, he still gets sties around his eyes. I had NEVER been so scared in my life, but I kept thinking, I know I was careful w/ him using gloves when he is nude, or during a bad no.2 in his diaper, so I knew that couldn't be it, plus I use germ x or purell after washing hands...PRECAUTIONS

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scjohn

HSV2MOM, I'm surprised your kid has genital herpes. But I've been researching about non-sexual ways herpes is transmitted and it seems it's possible to transmit it through skin-to-skin contact, bath water, towels, etc. Please use caution and don't let anyone misinform you into believing you can't spread herpes through touch or moist, inanimate objects.

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Kya

Giving birth to children vaginally when you have herpes does carry the risk of passing it to them, and only now if she showing signs. If indeed that is what it is and not just a rash of some kind.

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