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    • WilsoInAus
      Hey @whereismyanswer my only comment for now is that are you sure these are cold sores and not another condition such as angular cheilitis? Valtrex is effective against oral cold sores in 95%+ of cases so there's a chance that something else is contributing at least.
    • WilsoInAus
      Hey @Hjkl33 and welcome to the community. You are right to dismiss the IgM results, they have no real value in an adult for all the reasons I'm sure you have read about. Your positive test is a very low positive and hence very likely to be false. This combined with what I suspect has been no outbreaks makes a false positive highly likely. Another IgG test will help your understanding, just insist this is what you want.
    • whereismyanswer
      hey there! I get them on both corners of my mouth. the right side feels like it never heals, while the left has outbreaks less frequently.   I was thinking an immunologist might be my next step since my GP is really giving me nothing anymore.
    • WilsoInAus
      Hey @whereismyanswer a good place to start might be if you can tell us what do these outbreaks consist of, where are they? Always on you lips? It may be that an immunologist might also be a good idea, but a good dermatologist is usually brilliant. 
    • whereismyanswer
      Hello there. I'm a 24F, who has  had HSV 1 for 3 and a half years now. I got my first cold sore December of 2016 out of no where when I was 21. I was in school and working at a job that had me very stressed at all time. I came home one day and saw the bumps. Initially, I'd never thought anything of it as my dad always had them when I was growing up. Of course, you go on Google and after about 20 minutes of searching, you are absolutely devastated and disgusted with yourself. The first year after my 1st outbreak, I'd occasionally experience some shedding, but didn't get another breakout until the following year. Since that outbreak, I've pretty much steadily had cold sores every month for the last 2 and a half years. I was told birth control would help, because I was noticing outbreaks begin about a week before my cycle. Didn't change anything though. Earlier this year, I finally decided it was time to start suppressive therapy, given the fact that I had no success with natural remedies or hormone leveling using the birth control. I've seen no changes in the frequency of my cold sores since starting 1GM of Valcyclovior. It's been about 3 months, and I met with my doctor today to discuss the issue. She basically told me there was nothing she could do and to see a dermatologist. She also gave me the list of vitamins I already to take to try to include with my daily antiviral. I feel completely defeated. I don't know what to do now or if there is any hope. It hurts me so much because I'm so young and nothing has gotten better. Also, I don't think a dermatologist is the answer. Has anyone else experienced this?
hopefull123

8 Months later

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hopefull123

Hey everyone, so I recently went to redo my hsv 2 igg through herpselect after 8 months. The result interpretation is neg>0.90-1.10<pos.  Going back 8 months ago:

Oct 23, 2019- igg 1.03 (6 weeks after encounter)

Nov 26, 2019- igg 0.94 (11 1/2 weeks after)

Current May 20, 2020- igg 1.57 (9 months after)

I thought this would be lower but it looks like its getting higher. I don't know what to think. I haven't noticed no lesions, blisters, sores throughout the whole 8 months. I get itchy/ tingling feelings around groin area, but i don't know whether its herps or just normal itch. I'm really down because I truly thought i'd be cleared with a negative. Please, i would really appreciate anyones thought on this! Thank you.

 

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WilsoInAus

hey @hopefull123 most people who are infected would test over 5 after 8 months.

There are junk proteins that stick to the antigen that’s forms part of the IgG test and cause low positives. No one knows precisely why this happens or what these proteins are or what might be a cause for their presence.

If you’re seeking further confidence, the Westernblot is perfect if you can access it.

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hopefull123

Thank you for your feedback. With these results, do you think i'm positive or negative @WilsoInAus ? Also why do these proteins not do the same for the hsv 1 igg

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hopefull123

Also if any else had this issue and tested negative or positive later, please comment or leave feedback. All this is having me on an emotional rollercoaster.

 

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WilsoInAus
5 hours ago, hopefull123 said:

Thank you for your feedback. With these results, do you think i'm positive or negative @WilsoInAus ? Also why do these proteins not do the same for the hsv 1 igg

You can only go with the odds that would suggest the chance of someone like yourself going on to be positive would be less than 5%.

Proteins do impact HSV-1 testing as well, but as well over 50% of people have HSV-1 it just isn’t as noticeable or queried with Westernblot tests as often.

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hopefull123

I really appreciate your response! Where do you get your percentage’s from? Also i've read something that herpes can take years to get symptoms, whats that about? I don't exercise, or eat healthy (meaning eating veggies and stuff), I drink a lot(I'm a depressed alcoholic), I smoke cigs (or nicotine out of vapes). Knowing this, do you think if i was positive i would've had symptoms already?

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hopefull123

How would i go forth for the westernblot? or should i retest in a couple week?

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WilsoInAus
26 minutes ago, hopefull123 said:

I really appreciate your response! Where do you get your percentage’s from? Also i've read something that herpes can take years to get symptoms, whats that about? I don't exercise, or eat healthy (meaning eating veggies and stuff), I drink a lot(I'm a depressed alcoholic), I smoke cigs (or nicotine out of vapes). Knowing this, do you think if i was positive i would've had symptoms already?

Papers like this: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820239/

typically show that for positive people, about 30-50% of low positives. This is linear from about 5% at 1.1 to 95% at 3.5. Hence your 1.57 result is about a 20% chance of being a real positive.

If you have say a population chance of having herpes at 25% then this is 5% chance.

I am not sure where you read that, most people experience something when infected, especially if they have no type (1 or 2)  of herpes yet.

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hopefull123

Damn so reading that, from my understanding is that I have a 5% chance that its false positive. Because it says that above 1.5 there is a 4.3% its a false positive, but correct me of I'm wrong. My only issue is that it has no timeframe within testing individuals within having sex. The earliest it said was 2 week after sex. So the negative’s itself can be false. I'm hoping you're right tho. Thank you@WilsoInAus for responding. Sorry if i bother you with questions. Going back to what influences antibody production, what makes the antibodies (igg or whatever) value increase?

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