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    • Voyager2
      Sure hope this pans out. 
    • Voyager2
      Don't forget there are two promising vaccines on the prophylactic front (but only pre-clinical): The Trivalent vaccine worked well on guinea pigs:  https://pubmed.ncbi.nlm.nih.gov/32347775/ The Einstein (Xvax) vaccine also has a ways to go: https://x-vax.com/ The fact HSV529 is in yet another clinical trial is good news for herpsters. 
    • Davrk8
      thank you for the info. I am uncircumcised. I applied some clotrimazole cream during the last outbreak I noticed, which seem to do the trick (around a month ago). But now, there new dots are appearing at a different location on the glans. Wasnt sure if balanitis can come back so soon or if it could be something else. 
    • Josse
      Looks like mild balanitis. If you are uncircumcised then thats normal every now and then due to accumulation of yeast and the irritation of the foreskin
    • MikeHerp
      I think the simple reason is that this is a fund raiser that was started by our community rather than by Fred Hutch.  Or rather, FHC started it in response to our request.   I still think they should somehow feature it in their pages.  But anyway, that's just how they do it. Keep in mind that FHC's main focus is curing cancer.  It's a cancer research institute.  They might feel that putting stuff on their website that isn't directly related to cancer might give people the impression, especially cancer cure donors (who are by far the main donors to FHC), that FHC is losing its focus. So we have to work within these limits.   However, I do draw strength from the fact that FHC has tried to help us with the fund raiser.  Among others: 1.  When the new research paper is released, FHC has gotten an agreement with a prominent sexual health blogger, to promote the research and the fund raiser. 2.  There is another potential promotion in the works that might get back on track if the US is able to get the coronavirus under control. So FHC has actively helped us to promote the fund raiser.
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Shubhherpe

Redbiotech moving ahead!!

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Shubhherpe
Posted (edited)

Good news!! It seems like redbiotech are gearing up for the clinical trials of their most advanced asset - HSV2 Immunotherapy Vaccine. Remember that they had claimed 90% reduction of ghsv2 symptoms in guinea pigs post vaccination.

rsz_11screenshot_20200601-004818__01.jpg

Edited by Shubhherpe

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Shubhherpe

Also their CEO talked with Acuris about company's plan and mission and they'll also try to collaborate with other partners at Biodigital June8-12,2020.

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iFdUp

Great news, I am honestly enthused at the idea of relieving symptoms of suffering more than the idea of a full cure. IF that is what is achievable sooner. 

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Star33hcs
Posted (edited)
14 hours ago, iFdUp said:

Great news, I am honestly enthused at the idea of relieving symptoms of suffering more than the idea of a full cure. IF that is what is achievable sooner. 

90% is amazing😍

Edited by Star33hcs

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iFdUp

HSV-2 immunotherapy program

  • Therapeutic subunit vaccines, our lead candidates being RBT-3 and RBT-26
  • T-cell-mediated protection
  • Best-in-class antigens by engineering
  • Strong preclinical data: Redbiotec leads show 90% reduction of lesion score (nearly double that of GEN-003 from competitor’s program)
  • Aimed at outperforming antivirals, and allowing patients to stay symptom-free for >12 months with two injections

Potential of increasing antigen performance by

  • Optimization of epitope content
  • Evaluation of alternative adjuvant systems
  • Combination with other antigens

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iFdUp

Does this kind of sound like mAb therapy ? 

I wonder if mAb is the way forward. It certainly seems to be a wide spread approach at this point. 

Either way its sounding a lot like treatments will be multi dose for a while. 

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hk81

not really like mAb. I believe that mAb is way more expensive than a vaccine and it is not supposed to last 12 months..

About the need of a booster dose: it would not be the first vaccine that needs it. And usually booster doses get less frequent after each dose.

I'm encouraged by the good confidence that they have with their results!

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Shubhherpe
Posted (edited)
10 minutes ago, hk81 said:

not really like mAb. I believe that mAb is way more expensive than a vaccine and it is not supposed to last 12 months..

About the need of a booster dose: it would not be the first vaccine that needs it. And usually booster doses get less frequent after each dose.

I'm encouraged by the good confidence that they have with their results!

The pblm is they are not telling when they are going to start the trials. And also once their vaccine works they sell it to bigger vaccine companies ,fir instance they sold their cmv vaccine to pfizer. I don't know whether pfizer have released their vaccine in market till now or not.

Edited by Shubhherpe

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Arabicguy
On 7/5/2020 at 2:20 PM, Shubhherpe said:

The pblm is they are not telling when they are going to start the trials. And also once their vaccine works they sell it to bigger vaccine companies ,fir instance they sold their cmv vaccine to pfizer. I don't know whether pfizer have released their vaccine in market till now or not.

Pfizer bought the cmv vaccine in 2015 and they didn't proceed with clinical trials till now. Meanwhile moderna is I think in phase 3 of it's own cmv vaccine 

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hk81

Hopefully the pressure to have a HSV vaccine is higher than for CMV. I don't know much of the scenario for CMV is.. I haven't seen much talk

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iFdUp
Posted (edited)
5 hours ago, hk81 said:

Hopefully the pressure to have a HSV vaccine is higher than for CMV. I don't know much of the scenario for CMV is.. I haven't seen much talk

 

What shocks me is that more celebrities haven't privately funded Jerome Lab or Excision. 


I know a lot of rich and famous people don't have time to go poking around the internet .. but, especially as of lately they may have. 

Either way there are a lot of people out there that are influential that could have HSV or have someone important to them that does. I think there will be some pressure to get it done, especially in the states and europe. 

Edited by iFdUp

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Shubhherpe
Posted (edited)
14 minutes ago, iFdUp said:

 

What shocks me is that more celebrities haven't privately funded Jerome Lab or Excision. 


I know a lot of rich and famous people don't have time to go poking around the internet .. but, especially as of lately they may have. 

Either way there are a lot of people out there that are influential that could have HSV or have someone important to them that does. I think there will be some pressure to get it done, especially in the states and europe. 

Thats because may be they don't know about dr jeromes work. Even i was also not aware of that,, i came to know about that from this community only. I m sure if they know about this then they will donate big.  The kind of research dr jerome is carrying deserves to receive more limelight. Maybe once proven good in guinea pigs his research would make big headlines that would attract fundings.

Edited by Shubhherpe

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Arabicguy
9 hours ago, hk81 said:

Hopefully the pressure to have a HSV vaccine is higher than for CMV. I don't know much of the scenario for CMV is.. I haven't seen much talk

I have CMV too. CMV is actually harmless unless you are immuosuppressed for transplant or it infects a baby. Especially in the womb and the mother doesn't have antibodies for it. It can cause deformities in the baby. No adult complains of CMV or there are forums for the affected. Mainly small percentage of babies. Herpes doesn't infect in the womb but can be lethal to babies if they catch it on delivery 

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hk81

@Arabicguy thanks. Yes, that's what I thought. The little bastards in the herpes family are HSV2 and HSV1. The others are less virulent and they are even less routinely tested in STD clinics.

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WSX

Celebs are also sued for giving people herpes, so that could be scare away someone from making a public plea for help.

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Arabicguy
12 minutes ago, hk81 said:

@Arabicguy thanks. Yes, that's what I thought. The little bastards in the herpes family are HSV2 and HSV1. The others are less virulent and they are even less routinely tested in STD clinics.

CMV is not even an std. You can catch it in school. From a kiss from an adult. It is very prevalent some say between 70% to 90% depending on the country. But it is harmless and immune system manages it well.

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