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    • Runner278
      Here is an article that discusses postherpetic neuralgia. This is what my doctor will finally diagnose me with once I put it cleanly under his nose. While I haven’t had lesions, I’ve had many of the other symptoms of HSV2 that 5 drs, 4 urgent care professionals and Terri Warren has said “it’s not herpes”. I go for my western blot blood draw Thursday and I have an appointment with a neurologist on 9/1. This virus not only needs better treatment, it needs better drs.    https://www.herpesite.org/post-herpetic-neuralgia-from-genital-herpes/
    • themotion
      @Cas9 Hey, Sorry to bother you, but can you share your opinion on the content quoted above. Hope all is well.   Thank you
    • Aubrey77
    • WilsoInAus
      Hey @Aubrey77 these symptoms are not something that oral HSV-1 can cause. In the end herpes would do what it does best and this is cause a sore somewhere on the lips . It might tingle a little as it forms, be inconvenient as it blisters and then crust as it heals and all look a little unsightly. But that’s herpes.    No reason to disbelieve your doctors thoughts on your issues.
    • Aubrey77
      Any feed back is welcome. I get these small bumps inside my right cheek. They do not hurt or burst. They just come and go. I showed them to doctors and the say they come up with stress and foods. Problem is I have pain and muscle spasms down right arm and in legs. Are these all ongoing issues for getting virus? I am not sure was going on with my body anymore 
Shandyy

Will there ever be a cure?

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Shandyy

Does anyone think a cure is likely? And if so, how many years do you think until we can all be cured of this thing?

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hopeful22

The short answer yes there will be eventually. The most promising for a cure at the moment is by Dr. Jerome from Fred Hutch. Please look up his work on this thread. 

Best 

Hopefull22

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Shandyy

Thank you for that. I read somewhere else earlier that said most likely not a cure but a vaccine for people so they can’t get it off someone who has it and just better antivirals for us. 

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shadowgirl88
3 hours ago, Shandyy said:

Thank you for that. I read somewhere else earlier that said most likely not a cure but a vaccine for people so they can’t get it off someone who has it and just better antivirals for us. 

I feel you. We’re so desperate for a cure, that at times it’s hard to keep the faith. But I absolutely believe there will be a full cure.  10 years ago we could not cure Hepatitis C. Today we can.  We just have to keep hanging in there.

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iFdUp
Posted (edited)

I believe that any prediction we make now for the cure can't possibly be accurate.

With the way things are going to progress in the field of medicine over the next 10 years, I believe that the US will try to retake the forefront in production of medicine.

With the exposure to the pharma industry due to the COVID crisis there has been a huge amount of focus on shifting medical production to the main land states. 

On top of this there is the very real d*ck measuring competition between world super powers, since there isn't a cold war anymore that frontier has shifted a lot towards medical technology. 

Gene editing IS the next big thing. Gene editing will be a wide array of medicines, its a whole new plateau of science that is just teeming with benefits that we need to be sure are safe enough to delve into. 

After a few gene edits have made it main stream (which some are right now, with admittedly mixed results) we should see this process accelerate. Especially with regard to CURES. Cures shouldn't require quite the same amount of time to produce their data and prove safe. 

Edited by iFdUp

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Shubhherpe
Posted (edited)

To answer that question we will have to wait for dr jerome guinea pigs results (which i believe we will get to know in 1.5 years or sooner from now).These results will tell whether his therapy is of any theraupatic benefit or not. Till now everything looks so good.

I think in the phase 1 clinical trial itself we will be able to know whether it cures herpes or not or atleast provides a relief or not. If it proves like a cure in phase 1 then it will pressurize FDA to fast track it. Note that i read somewhere that the fda had fast tracked a gene therapy product. So in nut shell dr jerome work just needs to prove itself in phase 1 i believe. If it proves good in phase 1 then we might get it in 3-4 yrs.So the challenge for dr jerome is to reach phase 1 as soons as possible!

Apart from dr jerome we have also got excision biotheraupatics which is using crispr. It was the first company to show a functional cure for hiv in non human primates. And they are close to filing an ind for that. Note that their hiv product proved to be safe and effective in non human primates after 6 months of one time therapy. They are expected to file ind for hsv in 2022.(they have demonstrated functional cure for hsv in human cells)

Apart from gene therapy we have also got live virus vaccine concept like that of rational, x vax , exd12 which are also very strong contender though they will be functional cures only making us like those 85% asymptomatic persons.

Overall i believe their will be a cure or a functional cure in market atleast in 7-8 yrs from now(although u will come to know about that much before through trials)

Edited by Shubhherpe

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Runner278
4 hours ago, Shubhherpe said:

To answer that question we will have to wait for dr jerome guinea pigs results (which i believe we will get to know in 1.5 years or sooner from now).These results will tell whether his therapy is of any theraupatic benefit or not. Till now everything looks so good.

I think in the phase 1 clinical trial itself we will be able to know whether it cures herpes or not or atleast provides a relief or not. If it proves like a cure in phase 1 then it will pressurize FDA to fast track it. Note that i read somewhere that the fda had fast tracked a gene therapy product. So in nut shell dr jerome work just needs to prove itself in phase 1 i believe. If it proves good in phase 1 then we might get it in 3-4 yrs.So the challenge for dr jerome is to reach phase 1 as soons as possible!

Apart from dr jerome we have also got excision biotheraupatics which is using crispr. It was the first company to show a functional cure for hiv in non human primates. And they are close to filing an ind for that. Note that their hiv product proved to be safe and effective in non human primates after 6 months of one time therapy. They are expected to file ind for hsv in 2022.(they have demonstrated functional cure for hsv in human cells)

Apart from gene therapy we have also got live virus vaccine concept like that of rational, x vax , exd12 which are also very strong contender though they will be functional cures only making us like those 85% asymptomatic persons.

Overall i believe their will be a cure or a functional cure in market atleast in 7-8 yrs from now(although u will come to know about that much before through trials)

I appreciate all of you that take the time to field this question on a regular basis. I hope/think that this is somewhat a reflection of how quickly things are moving. Just wanted to say thank you for your expertise. It will take a village to get what we want/need. 

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Shandyy

Thank you all for all the useful information, greatly appreciated 😊

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BobinColorado
10 hours ago, Shubhherpe said:

To answer that question we will have to wait for dr jerome guinea pigs results (which i believe we will get to know in 1.5 years or sooner from now).These results will tell whether his therapy is of any theraupatic benefit or not. Till now everything looks so good.

Overall i believe their will be a cure or a functional cure in market atleast in 7-8 yrs from now(although u will come to know about that much before through trials)

Do you know if Dr. Jerome already has the guinea pigs in his lab and has he begun the process of testing and doing research on them?  Or when is he expected to begin on the pigs?

Hope your right about the 7 to 8 year timeframe.  Would be a cure or a functional cure while I am still young enough to enjoy it a bit!

 

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iFdUp
1 hour ago, BobinColorado said:

Do you know if Dr. Jerome already has the guinea pigs in his lab and has he begun the process of testing and doing research on them?  Or when is he expected to begin on the pigs?

Hope your right about the 7 to 8 year timeframe.  Would be a cure or a functional cure while I am still young enough to enjoy it a bit!

 

 

Despite my thoughts on the figure being too much of an unknown to guess ( it really depends on the level of 'break through' ) I do believe that we should have it within 10 years. 

There is a lot of skepticism out there, I choose to be healthily skeptical. Looking at the past trials and efforts with Herpes it is pretty quick to see that if it doesn't show promise within the first 50 million it will probably never go anywhere.

The stats that have justified clinical trials in the past are actually kind of laughable... specifically with regard to GEN 003. Yet look how much money was put into GEN without it going anywhere. 

The level of effect that we believe the meganuclease' therapy that Jerome Lab is developing already has 10x the promise that the GEN 003 vaccine did. Yet the Jerome Lab meganuclease hasn't anywhere near 50 million in funding, yet. 

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Elephant in the room?

I believe it will be shown within three months that HSV is treatable and the immune system can reach the virus via the action of the T cells. The 5CC is now accepted to three journals and many are watching and waiting for publishing. I find it hard to fathom why more people are not picking up on the issue when they  desperately want a cure. 

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Shubhherpe
Posted (edited)
9 hours ago, BobinColorado said:

Do you know if Dr. Jerome already has the guinea pigs in his lab and has he begun the process of testing and doing research on them?  Or when is he expected to begin on the pigs?

Hope your right about the 7 to 8 year timeframe.  Would be a cure or a functional cure while I am still young enough to enjoy it a bit!

 

He has already started with the guinea pigs last year. One thing i surely know that if it proves itself good in phase 1 then it will be fast tracked by fda. It should not take more than 3-4 yrs to be available in market if proven good in phase 1 trials on humans. The fda is not gonna unnecessarily delay the treatment because they know millions of millions people get infected every year.

Note that guinea pigs are gold standard for Herpes as they respond the same way as humans to hsv. So the guinea pigs results would be very important.

Edited by Shubhherpe

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Shubhherpe
7 hours ago, iFdUp said:

 

Despite my thoughts on the figure being too much of an unknown to guess ( it really depends on the level of 'break through' ) I do believe that we should have it within 10 years. 

There is a lot of skepticism out there, I choose to be healthily skeptical. Looking at the past trials and efforts with Herpes it is pretty quick to see that if it doesn't show promise within the first 50 million it will probably never go anywhere.

The stats that have justified clinical trials in the past are actually kind of laughable... specifically with regard to GEN 003. Yet look how much money was put into GEN without it going anywhere. 

The level of effect that we believe the meganuclease' therapy that Jerome Lab is developing already has 10x the promise that the GEN 003 vaccine did. Yet the Jerome Lab meganuclease hasn't anywhere near 50 million in funding, yet. 

Once proven good in guinea pigs they will surely get more funding. The researchers and doctors all over the world are very well aware of an urgent need of a cure for this virus.

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Shubhherpe
59 minutes ago, Just a human being said:

I believe it will be shown within three months that HSV is treatable and the immune system can reach the virus via the action of the T cells. The 5CC is now accepted to three journals and many are watching and waiting for publishing. I find it hard to fathom why more people are not picking up on the issue when they  desperately want a cure. 

People will believe only if it gets published ,no one will turn a hair on mere acceptance!

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Elephant in the room?
Just now, Shubhherpe said:

People will believe only if it gets published ,no one will turn a hair on mere acceptance!

They should be thinking more carefully. And once it’s published everyone needs to get a mirror and turn their brains inside out to get the big fat mess of what has happened in science and medicine. 

Josh Bloom censored me two days ago! Why is he unhappy that HSV is curable. Maybe he is aware of my publishing here I am not sure  Personally I’m not a fan of toilet humour but his “bulls@@t” iconography really annoyed me directed at the top integrative specialists of our time  So maybe he is feeling grumpy about that meme or maybe he is grumpy to be wrong and realise his organisation founded over 40 years ago has only muddied the waters rather than provide real science . 

Doesnt seem to me that science is so impartial as people claim. FDA regulations have a lot to do with a paper claiming a cure so he is totally wrong about that too! 

 

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Elephant in the room?
12 minutes ago, Just a human being said:

They should be thinking more carefully. And once it’s published everyone needs to get a mirror and turn their brains inside out to get the big fat mess of what has happened in science and medicine. 

Josh Bloom censored me two days ago! Why is he unhappy that HSV is curable. Maybe he is aware of my publishing here I am not sure  Personally I’m not a fan of toilet humour but his “bulls@@t” iconography really annoyed me directed at the top integrative specialists of our time  So maybe he is feeling grumpy about that meme or maybe he is grumpy to be wrong and realise his organisation founded over 40 years ago has only muddied the waters rather than provide real science . 

Doesnt seem to me that science is so impartial as people claim. FDA regulations have a lot to do with a paper claiming a cure so he is totally wrong about that too! 

 

I have to say I feel frustrated and angry about the serious deficiencies in science and society toTHINK. 

We have done it to ourselves...it’s shameful, embarrassing and really there are no words to really explain it. It’s shocking. 

People seriously need to wake up and demand dissolving these defunct, inert and disfunctional institutions NOW. 

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Elephant in the room?

WHO needs to end, FDA needs to be axed,, CDC needs to go. They are all useless and have utterly failed! 

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Elephant in the room?
Posted (edited)

And don’t even get me started on the media or academia!

CRIMINAL NEGLIGENCE!!! 

So my blood has started to boil the tragic damage let in the wake of an industry let loose due to neo liberalism! Tobacco science much of it JUNK! The harm, the horror and the pain. I cannot even speak the words as there are NONE!

Edited by Just a human being
There are no words that can express what has occurred in science and medicine and it’s effects on human healthcare. We have all allowed it and there are no words for this embarrassment of human societal stupidity.

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Shubhherpe
Posted (edited)
33 minutes ago, Just a human being said:

WHO needs to end, FDA needs to be axed,, CDC needs to go. They are all useless and have utterly failed! 

I agree with you on fda. Their work should only be to judge the safety of a drug and not effectiveness. But they are doing so to make more money from companies presenting the drug. If a vaccine is developed today then the fda will take 10-15 years to decide its effectiveness, this is complete bullshit!

Even billionaire peter thiel also said because of this stupid fda their is no way a drug can be discovered by serendipity like it used to be 30 yrs ago!

Edited by Shubhherpe

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Elephant in the room?
6 hours ago, Shubhherpe said:

I agree with you on fda. Their work should only be to judge the safety of a drug and not effectiveness. But they are doing so to make more money from companies presenting the drug. If a vaccine is developed today then the fda will take 10-15 years to decide its effectiveness, this is complete bullshit!

Even billionaire peter thiel also said because of this stupid fda their is no way a drug can be discovered by serendipity like it used to be 30 yrs ago!

The FDA is useless and it seems only to constantly ban natural substances. 

 

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BobinColorado
Posted (edited)
11 hours ago, Shubhherpe said:

He has already started with the guinea pigs last year.

Do you know when he will finish on the pigs?  How long do they normally monitor the pigs for in this type of research?   6 months or a year etc?  I guess im asking when are we likely to get word on if his hopefully very positive results?  Before the end of the year hopefully

Edited by BobinColorado

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Shubhherpe
22 hours ago, BobinColorado said:

Do you know when he will finish on the pigs?  How long do they normally monitor the pigs for in this type of research?   6 months or a year etc?  I guess im asking when are we likely to get word on if his hopefully very positive results?  Before the end of the year hopefully

By the end of this year we will have the result i guess! I hope for positive results too. In few other earlier studies AAVs have been shown to reach and transduce the dorsal root ganglion effectively. Now we just have to see how much of the virus dna is being cut by the enzymes in drg. Reaching the drg is no more a problem now. 10 years earlier their was nothing which could hit the latent virus in drg.

 

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ManagingIllness

I'll only speak to prophylactic, as therapeutic & cure seem harder. For a prophylactic we're over 10 years away. Once we have a solid phase 2 or phase 3 candidate, it'll be much easier to estimate. For example, something that had phase 2 trials showing 90% reduction in transmission is very promising. It would then move to phase 3 with the possibility of coming out within 3 years from that point in time.

Remember, people have been working on this virus for decades and decades, and there has been little progress. In other words, all the pre-clinical and phase 1 stuff should not be taken too seriously, as there is a massive graveyard of failures when it comes to this virus.

Be optimistic if you wish.

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Pokemon
10 minutes ago, ManagingIllness said:

I'll only speak to prophylactic, as therapeutic & cure seem harder. For a prophylactic we're over 10 years away. Once we have a solid phase 2 or phase 3 candidate, it'll be much easier to estimate. For example, something that had phase 2 trials showing 90% reduction in transmission is very promising. It would then move to phase 3 with the possibility of coming out within 3 years from that point in time.

Remember, people have been working on this virus for decades and decades, and there has been little progress. In other words, all the pre-clinical and phase 1 stuff should not be taken too seriously, as there is a massive graveyard of failures when it comes to this virus.

Be optimistic if you wish.

Among other reasons, I am optimistic that one positive outcome of COVID 19 will an enhanced ability to churn out vaccines.

 

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