Re: your first question (Have either of you had someone react negatively at first, then change? ).... No I haven't.. I have disclosed only twice but both wanted to be with me... Neither were too concerned about the virus (which I never passed to either) but my stress and fear of passing it certainly led to the end of the relationships..
Re: your second question (I feel like I destroyed a beautiful relationship with this disclosure. How do you not internalize the rejection and move on?)... You did not destroy the relationship! All you did was have sex (perfectly natural) and you did not ask for HSV... Your BF is the one who is destroying the relationship...and i'm sorry about that. As for the rejection, well in this case only the virus in your body is being rejected and so hopefully that makes it a lil easier as there is nothing you can do about that... (albeit it's probably more frustrating...)...
Hopefully someone with 'fairytale' stories (of which there are plenty who mention them here) will sweep in here soon to provide the support you need...but hopefully this helps...
Genocea is developing its vaccine within the regulatory framework of the FDA, therefore, finding funders is easy as long as the business case looks promising.
When you act outside the regulatory framework, a sophisticated investor will balk because the pathway to the market is far more complicated and proving the efficacy of the vaccine to an investor is also very difficult as there is no benchmark for an investor to evaluate the vaccine against
HSV-2. I had an initial blister which looked like an ingrown hair, then a rash developed and my Dr. diagnosed it as jock itch. A few more bumps but nothing ever became an open sore. Blood test later revealed HSV-2 at >5. I haven't had any noticeable lesions, but nerve pain/numbness since the initial symptoms started. I'm definitely confused about the whole thing, then again, it seems like it different for many people. Any suggestions?
The tests are type specific for HSV-1 and HSV-2. This means that the single antigen used to coat the testing well is either gG-1 or gG-2. Believe it or not, there is a combined test that coats the well with a combination of both gG-1 and gG-2.
Yep FDA killed a cure for prostate cancer. Engleman stated that in every single test the FDA ordered it was never reported to be toxic. Yet, they kept demanding more trials. Company filed for BK in 2014.
BTW FDA isn't the problem per se. Germany and UK are likewise just as strict as the FDA.
Also USA is actually the only partially free market on the planet for drug pricing. Socialized medicine in Europe and elsewhere means that the USA is the only place in the world you can make money researching new drugs. If European countries got out of regulating what drug companies can charge then it would open the door to more investments overseas in new drugs.
FUCK the FDA, and FUCK price controls on drugs which hurt innovation.
I'm going to jump in here.
1. It was simply a safety trial so no shedding measurements done; further that's expensive.
2. There was no clinical checking of symptoms; its self-reported.
You can't compare as Halford trial just finished the 3 shots while Amadeus and Genocea are already 6+ months ahead reporting interim data for investors.
No trouble raising millions? Sure, anybody can do it? No. Genocea has technology and people. First they have ATLAS, a proprietary rapid antigen identification screening system that finds targets of protective T cell responses as well as experienced management. They told investors they can now possibly get treatments for cancer as well as other numerous uncured diseases. They also have a unique powerful saponin adjuvant (Matrix-M) they've developed and are already generating revenue from that while they burn the money raised for R&D. They are more than just a possible HSV-2 vaccine. They have tech and products. Even if they fail at HSV they still will make millions on Matrix-M. What about Amadeus? They have money and people as well as other products besides a HSV2 vaccine. While Amadeus stock is in the toilet right now its not because its failing, rather every time they announce positive results earlier investors are unloading their stock.
That goes to show investing in vaccines is a long term gamble and that you need something other than a possible vaccine. Halford has developed a more accurate blood test for HSV2 called ABVIC. Time will tell whether they'll attract money to market and capitalize on that test while HSV2 vaccine testing is underway.